Regulation of Itch Scratching by Spinal GRP Receptors in Primates

灵长类动物脊髓 GRP 受体对瘙痒抓挠的调节

基本信息

  • 批准号:
    8492849
  • 负责人:
  • 金额:
    $ 19.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-07-01 至 2015-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Pruritus (itch sensation) is a symptom derived from many nervous system disorders that afflicts a large population of humans and is treated by a variety of pharmacological agents with variable success. Little effort has been made to develop valid animal models of itch for preclinical evaluation of potential antipruritics. Recent studies illustrate distinct species differences in the in vivo pharmacology of itch, which may contribute t different results or interpretations in itch research. Humans and monkeys have similar thresholds for detecting stimuli and the neural systems responsible for sensations in both species are fundamentally similar. Therefore, it is important to conduct studies using conscious behaving monkeys to validate animal behavioral models and to assess the effectiveness of potential antipruritics. In particular, previous studies have demonstrated that intrathecally administered morphine-induced scratching behavior in monkeys is mediated by central mu opioid receptors. Using pharmacological approaches, we intend to establish other experimental itch models using endogenous pruritogenic agents including ¿-endorphin and gastrin-releasing peptide and to evaluate the effectiveness of gastrin-releasing peptide receptor (GRPR) antagonists as antipruritics in a broader context in behaving monkeys. The proposed studies in this project will mainly develop and validate the monkey models of itch elicited by intrathecal administration of various ligands and will assess the potential treatment efficacy of GRPR antagonists in these models. In the proposed studies, scratching activity will be monitored by video recorders and quantified by observers blind to experimental conditions. The potential attenuation of scratching activity by rationally selected pharmacological agents will be studied in different experimental itch models. The dose- response curve, time course of each agent, and possible side effects will be thoroughly investigated. Collectively, these studies will develop vald animal models of itch, improve scientific knowledge of GRPR in primates, and advance the discovery of innovative therapies targeting the GRPR for the treatment of pruritus in humans.
描述(由申请人提供):瘙痒(瘙痒感)是一种源自许多神经系统疾病的症状,困扰着大量人群,并通过各种药物治疗,取得了不同的成功。几乎没有努力开发有效的瘙痒动物模型用于潜在止痒剂的临床前评价。最近的研究表明,在瘙痒的体内药理学中存在明显的种属差异,这可能导致瘙痒研究的不同结果或解释。人类和猴子有相似的阈值来检测刺激,两个物种负责感觉的神经系统基本相似。因此,使用有意识行为的猴子进行研究以验证动物行为模型并评估潜在止痒剂的有效性是重要的。特别是,以前的研究表明,鞘内给药吗啡诱导的抓挠行为的猴子是由中央μ阿片受体介导。使用药理学方法,我们打算建立其他实验性瘙痒模型,使用内源性致瘙痒剂,包括<$-内啡肽和胃泌素释放肽,并评估胃泌素释放肽受体(GRPR)拮抗剂作为止痒剂在更广泛的范围内在行为猴子的有效性。本项目拟开展的研究将主要开发和验证鞘内注射各种配体引起的猴瘙痒模型,并将评估GRPR拮抗剂在这些模型中的潜在治疗效果。在拟定研究中,将通过录像机监测抓挠活动,并由对实验条件不知情的观察者进行定量。将研究合理选择的药理学试剂对抓挠活性的潜在衰减, 不同的瘙痒实验模型剂量-反应曲线,每种药物的时间过程,以及可能的副作用将被彻底研究.总的来说,这些研究将开发有效的瘙痒动物模型,提高灵长类动物中GRPR的科学知识,并推进针对GRPR治疗人类瘙痒症的创新疗法的发现。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MEI-CHUAN KO其他文献

MEI-CHUAN KO的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MEI-CHUAN KO', 18)}}的其他基金

Buprenorphine analogs for the treatment of opioid abuse
丁丙诺啡类似物用于治疗阿片类药物滥用
  • 批准号:
    10549345
  • 财政年份:
    2021
  • 资助金额:
    $ 19.51万
  • 项目类别:
Buprenorphine analogs for the treatment of opioid abuse
丁丙诺啡类似物用于治疗阿片类药物滥用
  • 批准号:
    10182436
  • 财政年份:
    2021
  • 资助金额:
    $ 19.51万
  • 项目类别:
Buprenorphine analogs for the treatment of opioid abuse
丁丙诺啡类似物用于治疗阿片类药物滥用
  • 批准号:
    10359832
  • 财政年份:
    2021
  • 资助金额:
    $ 19.51万
  • 项目类别:
Diverse Effects of a Stress-Related Ligand, Corticotropin-Releasing Factor, in Non-Human Primates
压力相关配体促肾上腺皮质激素释放因子对非人类灵长类动物的多种影响
  • 批准号:
    9751235
  • 财政年份:
    2018
  • 资助金额:
    $ 19.51万
  • 项目类别:
Effects of a G protein-biased mu opioid receptor agonist PZM21 in primates
G 蛋白偏向的 mu 阿片受体激动剂 PZM21 对灵长类动物的影响
  • 批准号:
    9404668
  • 财政年份:
    2017
  • 资助金额:
    $ 19.51万
  • 项目类别:
A novel spinal analgesic with mixed MOP/NOP actions in primates
一种对灵长类动物具有混合 MOP/NOP 作用的新型脊髓镇痛药
  • 批准号:
    8953222
  • 财政年份:
    2015
  • 资助金额:
    $ 19.51万
  • 项目类别:
A novel spinal analgesic with mixed MOP/NOP actions in primates
一种对灵长类动物具有混合 MOP/NOP 作用的新型脊髓镇痛药
  • 批准号:
    9097674
  • 财政年份:
    2015
  • 资助金额:
    $ 19.51万
  • 项目类别:
Regulation of Itch Scratching by Spinal GRP Receptors in Primates
灵长类动物脊髓 GRP 受体对瘙痒抓挠的调节
  • 批准号:
    8692540
  • 财政年份:
    2013
  • 资助金额:
    $ 19.51万
  • 项目类别:
Effects of a Buprenorphine Analog with Mixed MOP/NOP Actions in Primates
丁丙诺啡类似物与 MOP/NOP 混合作用对灵长类动物的影响
  • 批准号:
    8492538
  • 财政年份:
    2013
  • 资助金额:
    $ 19.51万
  • 项目类别:
Effects of a Buprenorphine Analog with Mixed MOP/NOP Actions in Primates
丁丙诺啡类似物与 MOP/NOP 混合作用对灵长类动物的影响
  • 批准号:
    8666731
  • 财政年份:
    2013
  • 资助金额:
    $ 19.51万
  • 项目类别:

相似海外基金

Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
  • 批准号:
    495434
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
  • 批准号:
    10586596
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
  • 批准号:
    10590479
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
  • 批准号:
    10642519
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
  • 批准号:
    23K06011
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
  • 批准号:
    10682117
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
  • 批准号:
    10708517
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
  • 批准号:
    10575566
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
  • 批准号:
    23K15696
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
  • 批准号:
    23K15867
  • 财政年份:
    2023
  • 资助金额:
    $ 19.51万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了