Enhancing the CARRA: Integration and Dissemination of Clinical Data

增强 CARRA:临床数据的整合和传播

基本信息

  • 批准号:
    8546978
  • 负责人:
  • 金额:
    $ 17.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-09-18 至 2016-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The CARRA Rheumatic Diseases Core Center (CARRA-RDCC) requests funding for expansion of the clinical and translational research mission of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). CARRA's mission is to prevent, treat and cure rheumatic diseases in children and adolescents through fostering, facilitating and conducting high quality research. CARRA has established a consortium of highly respected pediatric rheumatologist across North America to foster that mission. The CARRA-RDCC looks to build upon existing infrastructure within CARRA and CARRA participating institutions to facilitate the application of state of the art technologies to clinical and translational research in childhood rheumatic disease, focusing on juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis and localized scleroderma. Despite the explosion in potential therapeutic options for these diseases with the availability of multiple biologic agents, there continues to be a lack of understanding of basic epidemiology and pathophysiology to guide treatment. There exists a compelling need for 1) biomarkers that are disease specific, parallel disease activity, and predict response to therapy, and 2) a better understanding of the epidemiologic and pathophysiologic basis of these diseases that can lead to new therapeutic options and cure. These two needs define the goals of the current application. The CARRA-RDCC will consist of one Administrative Core and three Research Cores. The Research Cores will provide CARRA investigators with access to biospecimens from an inception cohort (CARRA Tissue Repository Core B (TRC), Director: Thompson (Cincinnati Children's Hospital Medical Center)),clinical data from the CARRA Registry as well as clinical data from other existing databases (CARRA Clinical Data & Informatics Core C (CDIC). Director: Schanberg (Duke Clinical Research Institute), Associate Directors: Inman (University of Utah), Natter (Boston's Children's Hospital)), and access to innovative research technologies to assess immune function (Immune Function & Analysis Core D (IFC), Director: Mellins (Stanford University), Associate Director: Albani (Sanford-Burnham). The Administrative Core (Director: Schanberg (Duke Clinical Research Institute), Associate Director: llowite (Albert Einstein) will coordinate the Center's efforts and provide an enrichment program focused on young investigators. Together, these components will provide services and resources to accelerate progress toward the goals of the center as well as foster collaborations and interdisciplinary interactions which enhance research capabilities of the CARRA pediatric rheumatology research base.
描述(由申请人提供):CARRA风湿病核心中心(CARRA-RDCC)要求为儿童关节炎和风湿病研究联盟(CARRA)的临床和转化研究使命的扩展提供资金。CARRA的使命是通过促进、促进和开展高质量的研究来预防、治疗和治愈儿童和青少年风湿性疾病。CARRA已经建立了一个由北美备受尊敬的儿科风湿病学家组成的联盟,以促进这一使命。CARRA-RDCC希望建立在CARRA和CARRA参与机构的现有基础设施上,以促进最先进技术在儿童风湿性疾病的临床和转化研究中的应用,重点关注青少年特发性关节炎,系统性红斑狼疮,青少年皮肌炎和局限性硬皮病。尽管随着多种生物制剂的可用性,这些疾病的潜在治疗选择激增,但仍然缺乏对基本流行病学和病理生理学的理解来指导治疗。迫切需要1)疾病特异性、平行疾病活动并预测对治疗反应的生物标志物,以及2)更好地理解这些疾病的流行病学和病理生理学基础,这可以导致新的治疗选择和治愈。这两个需求定义了当前应用程序的目标。CARRA-RDCC将由一个行政核心和三个研究核心组成。研究核心将为CARRA研究者提供来自初始队列的生物样本(CARRA组织储存库核心B(TRC),主任:Thompson(辛辛那提儿童医院医疗中心))、来自CARRA登记处的临床数据以及来自其他现有数据库的临床数据(CARRA临床数据和信息学核心C(CDIC))。导演:Schanberg(杜克临床研究所),副主任:Inman(犹他州大学),Natter(波士顿儿童医院)),以及获得创新研究技术来评估免疫功能(免疫功能与分析核心D(IFC),主任:Mellins(斯坦福大学),副主任:Albani(Sanford-Burnham)。行政核心(主任:Schanberg(杜克临床研究所),副主任:llowite(阿尔伯特爱因斯坦)将协调中心的努力,并提供一个丰富的计划,重点是年轻的研究人员。这些组成部分将共同提供服务和资源,以加快实现中心目标的进展,并促进合作和跨学科的互动,提高CARRA儿科风湿病学研究基地的研究能力。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Laura E Schanberg其他文献

Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature
  • DOI:
    10.1186/s12969-015-0008-x
  • 发表时间:
    2015-04-23
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Reut Gurion;Vin Tangpricha;Eric Yow;Laura E Schanberg;Grace A McComsey;Angela Byun Robinson
  • 通讯作者:
    Angela Byun Robinson
Developing consensus treatment plans for proliferative lupus nephritis in childhood-onset systemic lupus erythematous
  • DOI:
    10.1186/1546-0096-10-s1-a31
  • 发表时间:
    2012-07-13
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Rina Mina;Hermine Brunner;Barbara Anne Eberhard;Marilynn G Punaro;Stacy P Ardoin;Marisa S Klein-Gitelman;Linda Wagner-Weiner;Lakshmi N Moorthy;Joyce J Hsu;Eyal Muscal;Suhas M Radhakrishna;Laura E Schanberg;Carol A Wallace;Norman T Ilowite;Emily Von Scheven
  • 通讯作者:
    Emily Von Scheven
The management of pediatric systemic lupus erythematosus
儿童系统性红斑狼疮的管理
  • DOI:
    10.1038/ncprheum0046
  • 发表时间:
    2005-12-01
  • 期刊:
  • 影响因子:
    32.700
  • 作者:
    Stacy P Ardoin;Laura E Schanberg
  • 通讯作者:
    Laura E Schanberg
The childhood arthritis & rheumatology research alliance network registry: demographics and characteristics of the initial 6-month cohort
  • DOI:
    10.1186/1546-0096-10-s1-a57
  • 发表时间:
    2012-07-13
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Marc D Natter;Jane R Winsor;Kathleen A Fox;Norman T Ilowite;Kenneth D Mandl;Kelly L Mieszkalski;Christy I Sandborg;John S Sundy;Carol A Wallace;Laura E Schanberg
  • 通讯作者:
    Laura E Schanberg
The effects of early aggressive therapy in JIA: results of the TREAT study
  • DOI:
    10.1186/1546-0096-10-s1-a56
  • 发表时间:
    2012-07-13
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Carol A Wallace;Edward H Giannini;Steven J Spalding;Philip J Hashkes;Kathleen M O’Neil;Andrew S Zeft;Ilona S Szer;Sarah M Ringold;Hermine Brunner;Laura E Schanberg;Robert P Sundel;Diana Milojevic;Marilynn G Punaro;Peter Chira;Beth S Gottlieb;Gloria C Higgins;Norman T Ilowite;Yukiko Kimura;Bin Huang;Daniel J Lovell
  • 通讯作者:
    Daniel J Lovell

Laura E Schanberg的其他文献

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{{ truncateString('Laura E Schanberg', 18)}}的其他基金

Enhancing the CARRA: Integration and Dissemination of Clinical Data
增强 CARRA:临床数据的整合和传播
  • 批准号:
    8436634
  • 财政年份:
    2012
  • 资助金额:
    $ 17.87万
  • 项目类别:
Electronic Diary Assessment of Pain in Juvenile Arthritis
幼年关节炎疼痛的电子日记评估
  • 批准号:
    7904862
  • 财政年份:
    2008
  • 资助金额:
    $ 17.87万
  • 项目类别:
Electronic Diary Assessment of Pain in Juvenile Arthritis
幼年关节炎疼痛的电子日记评估
  • 批准号:
    7526479
  • 财政年份:
    2008
  • 资助金额:
    $ 17.87万
  • 项目类别:
Electronic Diary Assessment of Pain in Juvenile Arthritis
幼年关节炎疼痛的电子日记评估
  • 批准号:
    7675336
  • 财政年份:
    2008
  • 资助金额:
    $ 17.87万
  • 项目类别:
DAILY STRESS, MOOD AND DISEASE ACTIVITY IN JRA
JRA 中的日常压力、情绪和疾病​​活动
  • 批准号:
    2875460
  • 财政年份:
    1998
  • 资助金额:
    $ 17.87万
  • 项目类别:
REGULATION OF THE T CELL-SPECIFIC GENE CD7
T 细胞特异性基因 CD7 的调控
  • 批准号:
    2077405
  • 财政年份:
    1992
  • 资助金额:
    $ 17.87万
  • 项目类别:
REGULATION OF THE T CELL-SPECIFIC GENE CD7
T 细胞特异性基因 CD7 的调控
  • 批准号:
    2077407
  • 财政年份:
    1992
  • 资助金额:
    $ 17.87万
  • 项目类别:
REGULATION OF THE T CELL-SPECIFIC GENE CD7
T 细胞特异性基因 CD7 的调控
  • 批准号:
    2077406
  • 财政年份:
    1992
  • 资助金额:
    $ 17.87万
  • 项目类别:
REGULATION OF THE T CELL-SPECIFIC GENE CD7
T 细胞特异性基因 CD7 的调控
  • 批准号:
    3079365
  • 财政年份:
    1992
  • 资助金额:
    $ 17.87万
  • 项目类别:
REGULATION OF THE T CELL-SPECIFIC GENE CD7
T 细胞特异性基因 CD7 的调控
  • 批准号:
    3079366
  • 财政年份:
    1992
  • 资助金额:
    $ 17.87万
  • 项目类别:

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