Role of S100A7 in breast cancer progression and metastasis

S100A7 在乳腺癌进展和转移中的作用

基本信息

  • 批准号:
    8699159
  • 负责人:
  • 金额:
    $ 29.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-07 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): S100A7 is highly expressed in ER?- invasive carcinoma, as well as in high grade ductal carcinomas in situ (DCIS), and therefore may play an important role in breast cancer progression and metastasis. Our preliminary studies indicate that S100A7 has differential effects on ER?+ and ER?- cells; it enhances growth and metastasis in ER?- and inhibits growth in ER?+ breast cancer cells. However, it remains to be determined if and how S100A7 modulates differential effects in ER?+ and ER?- breast cancer subtypes. Our central hypothesis is that the differential effects of S100A7 are a result of two different pathways: in ER?-, it may modulate the tumor microenvironment by binding to receptor for advance glycation end products (RAGE) and transactivating EGFR; in ER?+ cells, it may regulate the 2-catenin pathway. The mortality of patients is significantly caused by the invasive characteristics of ER?-, especially in triple-negative breast cancers, and the development of drug resistance in ER?+ breast cancers; as a result, understanding how S100A7 may modulate differential effects in ER?- and ER?+ breast cancers is of fundamental importance. To this end, we will use an innovative, multi-disciplinary approach to analyze the role and molecular mechanisms of S100A7, taking advantage of transgenic and knockout mouse model systems. In Aim 1, we will further analyze S100A7 expression in breast cancer tissue microarrays in different grades and subtypes, especially triple-negative breast cancers. In Aim 2, we will further characterize the role of S100A7 in modulating the growth and metastasis of ER?+ and ER?- cells in in vivo mouse models. In Aim 3, we will analyze the role of S100A7 in breast cancer progression and metastasis in transgenic and knockout mouse model systems. Finally, in Aim 4, we will delineate the S100A7-mediated molecular mechanisms that enhance growth and metastasis of ER?- cells and inhibit cell proliferation and migration of ER?+ cells. Insight gained from these studies may help in developing novel and innovative therapies for highly invasive ER?- and drug resistant ER?+ breast cancers.
描述(申请人提供):S100 A7在ER?中高度表达。浸润性癌以及高级别导管原位癌(DCIS)中,并且因此可能在乳腺癌进展和转移中起重要作用。我们的初步研究表明,S100 A7对ER?+而ER?细胞;它增强ER?的生长和转移。并抑制ER?+的生长乳腺癌细胞然而,S100 A7是否以及如何调节ER?+中的差异效应仍有待确定。而ER?乳腺癌亚型。我们的中心假设是,S100 A7的不同作用是两种不同途径的结果:在ER?-,它可能通过与晚期糖基化终产物受体(receptor for advanced glycation end products,EGFR)结合和反式激活EGFR来调节肿瘤微环境;细胞,它可以调节2-catenin途径。ER?-的侵袭性是导致患者死亡的重要原因,尤其是在三阴性乳腺癌中,以及ER?+乳腺癌;因此,了解S100 A7如何调节ER?所以,+?乳腺癌具有根本重要性。为此,我们将采用创新的多学科方法,利用转基因和基因敲除小鼠模型系统,分析S100 A7的作用和分子机制。目的1:进一步分析S100 A7在不同级别和亚型的乳腺癌组织微阵列中的表达,特别是三阴性乳腺癌。在目的2中,我们将进一步表征S100 A7在调节ER?+细胞生长和转移中的作用。而ER?在体内小鼠模型中的细胞。在目标3中,我们将分析S100 A7在转基因和敲除小鼠模型系统中在乳腺癌进展和转移中的作用。最后,在目标4中,我们将描述S100 A7介导的增强ER?细胞和抑制细胞增殖和迁移的ER?+细胞从这些研究中获得的见解可能有助于开发用于高度侵入性ER?的新型和创新疗法。和耐药ER?+乳腺癌

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Ramesh K. Ganju其他文献

CD10/NEP in non-small cell lung carcinomas. Relationship to cellular proliferation.
非小细胞肺癌中的 CD10/NEP。
  • DOI:
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    15.9
  • 作者:
    Ramesh K. Ganju;Mary E. Sunday;Dean G. Tsarwhas;A. Card;M. Shipp
  • 通讯作者:
    M. Shipp
MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis
微小 RNA-379-5p 通过调节 RAD18/Polη 轴减弱卵巢癌中的癌症干细胞并降低顺铂耐药性
  • DOI:
    10.1038/s41419-025-07430-5
  • 发表时间:
    2025-02-27
  • 期刊:
  • 影响因子:
    9.600
  • 作者:
    Devendra Shukla;Sanjay Mishra;Tanima Mandal;Manish Charan;Ajeet Kumar Verma;Md Maqsood Ahamad Khan;Nabanita Chatterjee;Amit Kumar Dixit;Senthil Kumar Ganesan;Ramesh K. Ganju;Amit Kumar Srivastava
  • 通讯作者:
    Amit Kumar Srivastava
Erratum to: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
  • DOI:
    10.1186/s12943-015-0451-9
  • 发表时间:
    2015-11-16
  • 期刊:
  • 影响因子:
    33.900
  • 作者:
    Helong Zhao;Tasha Wilkie;Yadwinder Deol;Amita Sneh;Akaansha Ganju;Mustafa Basree;Mohd W. Nasser;Ramesh K. Ganju
  • 通讯作者:
    Ramesh K. Ganju

Ramesh K. Ganju的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Ramesh K. Ganju', 18)}}的其他基金

Addressing cancer disparity through defining the molecular link between breast feeding and triple negative breast cancer
通过定义母乳喂养与三阴性乳腺癌之间的分子联系来解决癌症差异
  • 批准号:
    9888345
  • 财政年份:
    2019
  • 资助金额:
    $ 29.19万
  • 项目类别:
Addressing cancer disparity through defining the molecular link between breast feeding and triple negative breast cancer
通过定义母乳喂养与三阴性乳腺癌之间的分子联系来解决癌症差异
  • 批准号:
    10372950
  • 财政年份:
    2019
  • 资助金额:
    $ 29.19万
  • 项目类别:
Addressing cancer disparity through defining the molecular link between breast feeding and triple negative breast cancer
通过定义母乳喂养与三阴性乳腺癌之间的分子联系来解决癌症差异
  • 批准号:
    10590700
  • 财政年份:
    2019
  • 资助金额:
    $ 29.19万
  • 项目类别:
Role of S100A7 in breast cancer progression and metastasis
S100A7 在乳腺癌进展和转移中的作用
  • 批准号:
    8526420
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
合成大麻素作为非小细胞肺癌的新型治疗策略
  • 批准号:
    8294608
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Role of S100A7 in breast cancer progression and metastasis
S100A7 在乳腺癌进展和转移中的作用
  • 批准号:
    8329625
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Role of S100A7 in breast cancer progression and metastasis
S100A7 在乳腺癌进展和转移中的作用
  • 批准号:
    8777633
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Novel approaches to attenuate lipopolysaccharide-induced inflammation
减轻脂多糖诱导的炎症的新方法
  • 批准号:
    8291967
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Role of S100A7 in breast cancer progression and metastasis
S100A7 在乳腺癌进展和转移中的作用
  • 批准号:
    8841515
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:
Role of S100A7 in breast cancer progression and metastasis
S100A7 在乳腺癌进展和转移中的作用
  • 批准号:
    8113028
  • 财政年份:
    2011
  • 资助金额:
    $ 29.19万
  • 项目类别:

相似海外基金

Characterizing RNA regulation in B lymphocytes
B 淋巴细胞中 RNA 调控的特征
  • 批准号:
    502601
  • 财政年份:
    2024
  • 资助金额:
    $ 29.19万
  • 项目类别:
B Lymphocytes in Autoimmune Disease
自身免疫性疾病中的 B 淋巴细胞
  • 批准号:
    10370125
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
Characterization of Streptococcus suis interactions with B lymphocytes
猪链球菌与 B 淋巴细胞相互作用的表征
  • 批准号:
    573206-2022
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
    University Undergraduate Student Research Awards
Myocardial-associated B lymphocytes and inflammatory injury
心肌相关B淋巴细胞与炎症损伤
  • 批准号:
    10543825
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
Altered B lymphocytes Due to Tungstate Exposure
钨酸盐暴露导致 B 淋巴细胞发生改变
  • 批准号:
    RGPIN-2020-05899
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of signaling and cytoskeletal rearrangements in B-lymphocytes
B 淋巴细胞信号传导和细胞骨架重排的调节
  • 批准号:
    RGPIN-2019-04911
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
    Discovery Grants Program - Individual
Myocardial-associated B lymphocytes and inflammatory injury
心肌相关B淋巴细胞与炎症损伤
  • 批准号:
    10339541
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
Exploring RNA helicase DDX the role of the1 at the crossroad of DNA repair processes in B lymphocytes
探索 RNA 解旋酶 DDX 在 B 淋巴细胞 DNA 修复过程十字路口的作用
  • 批准号:
    BB/X511560/1
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
    Training Grant
Role and regulation of extracellular vesicles generated in response to stimulation of CD24 on B lymphocytes
B 淋巴细胞上 CD24 刺激产生的细胞外囊泡的作用和调节
  • 批准号:
    RGPIN-2022-03800
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
    Discovery Grants Program - Individual
B Lymphocytes in Autoimmune Disease
自身免疫性疾病中的 B 淋巴细胞
  • 批准号:
    10640819
  • 财政年份:
    2022
  • 资助金额:
    $ 29.19万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了