Metabolic Benefits Of Peripheral Fat Accumulation

周围脂肪堆积的代谢益处

• 批准号: 8702535
• 负责人: MICHELLE T. FOSTER
• 金额: $ 7.44万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8702535
• 关键词: Adipose tissue; Biology; Cardiovascular Diseases; Central obesity; Comorbidity; Complement; Data; Data Set; Development; Drug or chemical Tissue Distribution; Dyslipidemias; Excision; Fatty acid glycerol esters; Goals; Hypertension; Impairment; Individual; Insulin; Insulin Resistance; Intra-abdominal; Laboratories; Link; Lipids; Liver; Mediating; Mentored Research Scientist Development Award; Metabolic; Metabolic Diseases; Methods; Modeling; Mus; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pathway interactions; Peripheral; Resistance; Risk; Risk Factors; Role; Skeletal Muscle; Testing; Therapeutic; Time; Tissues; Tracer; Triglycerides; Visceral; adverse outcome; blood glucose regulation; glucose metabolism; glucose tolerance; impaired glucose tolerance; improved; insight; insulin sensitivity; novel; obesity prevention; obesity treatment; protective effect; public health relevance; response; subcutaneous; treatment strategy

DESCRIPTION (provided by applicant): Adipose tissue distribution is an important determinant of obesity-related comorbidities. Peripheral obesity (subcutaneous/gluteofemoral adipose tissue accumulation) is associated with improved insulin sensitivity and lower risk for metabolic co-morbidities such as dyslipidemia, cardiovascular disease, insulin resistance and type-2-diabetes. It has been postulated that the protective effects of peripheral adipose tissue occur via its ability to sequester surplus lipid and thus serve as a "metabolic sink". We propose to systematically examine how peripheral adipose tissue serves a protective role in obesity using a model in which various amounts of peripheral adipose tissue are removed. In support of this, removal of peripheral adipose tissue leads to impaired glucose tolerance and tissue-specific lipid accumulation in mice. Aim 1 investigates the role of peripheral adipose tissue in glucose homeostasis. Aim 2 will examine how peripheral adipose tissue removal leads to impaired glucose tolerance. Overall, completion of these aims will provide new insight into how peripheral adipose tissue regulates glucose homeostasis. Results from these studies will fundamentally advance the field of adipose tissue biology and increase our understanding of potential therapeutic strategies for obesity prevention and treatment.

描述（由申请方提供）：脂肪组织分布是肥胖相关合并症的重要决定因素。周围性肥胖（皮下/臀股脂肪组织积聚）与胰岛素敏感性改善和代谢共病（如血脂异常、心血管疾病、胰岛素抵抗和2型糖尿病）风险降低相关。据推测，外周脂肪组织的保护作用是通过其隔离多余脂质的能力而发生的，从而起到“代谢库”的作用。我们建议系统地研究如何外周脂肪组织在肥胖症中起保护作用，使用模型，其中各种量的外周脂肪组织被删除。为了支持这一点，去除外周脂肪组织导致小鼠葡萄糖耐量受损和组织特异性脂质蓄积。目的1探讨外周脂肪组织在葡萄糖稳态中的作用。目标2将研究外周脂肪组织切除如何导致糖耐量受损。总之，这些目标的完成将为外周脂肪组织如何调节葡萄糖稳态提供新的见解。这些研究的结果将从根本上推进脂肪组织生物学领域，并增加我们对肥胖预防和治疗的潜在治疗策略的理解。