Advanced Development of TIES-Enhancing Access to Tissue for Cancer Research

描述（由申请人提供）：存档的人体组织是翻译研究的重要资源。来自癌症患者的福尔马林固定石蜡包埋（FFPE）组织用于广泛的分析，包括RT-PCR， SNP分析，多重生物标志物，成像生物标志物，靶向外显子组，全外显子组和全基因组测序。在患者护理期间产生的剩余FFPE组织是“回顾性的”；在特定情况下使用这些组织不需要征得同意。对于个性化医学研究人员来说，这些标本是在应用于个体患者之前进行生物标志物验证、详细分子分析和系统建模的重要资源。但在癌症研究中，能否接触到这些人体组织往往是一个限制因素。我们建议对TIES软件进行进一步开发，以(1)提高使用FFPE支持人类肿瘤分子表征的机构能力，(2)增加对癌症中心内组织的访问，(3)提高癌症中心之间共享组织和相关表型数据的能力。

DESCRIPTION (provided by applicant): Archived human tissues are an essential resource for translational research. Formalin-fixed, paraffin-embedded (FFPE) tissues from cancer patients are used in a wide range of assays, including RT-PCR, SNP profiling, multiplex biomarkers, imaging biomarkers, targeted exome, whole exome, and whole genome sequencing. Remainder FFPE tissues generated during patient care are 'retrospective'; use of these tissues under specific conditions does not require consent. For personalized medicine researchers, these specimens are vital resources enabling biomarker validation, detailed molecular analysis, and systems modeling before application is made to individual patients. But access to these human tissues is often a rate limiting factor in cancer research. We propose advanced development of the TIES software to (1) increase institutional capacity for using FFPE to support molecular characterization of human tumors, (2) increase access to tissues within cancer centers, and (3) improve the ability to share tissues and associated phenotype data among cancer centers.