课题基金 / 基金详情

The Combinatorial Design of Protein Molecular Switches

The Combinatorial Design of Protein Molecular Switches
蛋白质分子开关的组合设计
批准号:
8641375
负责人:
MARC A OSTERMEIER
金额:
$35.92万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2003
资助国家:
美国
项目状态:
已结题
起止时间:
2003-07-01 至 2017-02-28

项目摘要

项目成果

MARC A OSTERMEIER的其他基金

相似基金

相关文献

中文摘要
翻译
描述(由申请人提供):作为开关的蛋白质作为选择性蛋白质治疗剂具有很大的前景。PI先前的研究已经证明,蛋白质开关可以通过在两个基因之间创建大量不同的融合体并使这些基因融合体在实验室中进化来工程化。这种定向进化策略将用于开发和改进蛋白质开关,以有效地在癌细胞中选择性地激活前药。将评价这些开关使用内源性表达和通过全身递送在体内消除肿瘤异种移植物的能力。这些开关与适当的前药组合具有作为治疗癌症的靶向治疗剂的潜力。
英文摘要
DESCRIPTION (provided by applicant): Proteins that behave as switches hold great promise as selective protein therapeutics. Previous studies by the PI have demonstrated that protein switches can be engineered by creating a large number of different fusions between two genes and subjecting these gene fusions to evolution in the lab. Such directed evolution strategies will be used to develop and improve protein switches to effectively activate prodrugs selectively in cancer cells. These switches will be evaluated for their ability to eliminate tumor xenographs in vivo using endogenous expression and via systemic delivery. These switches in combination with the appropriate prodrug have potential as a targeted therapeutic for the treatment of cancer.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Live Cell Fluorescence Imaging Using Molecular Switches
  • 批准号:
    7022699
  • 项目类别:
  • 资助金额:
    $11.97万
  • 财政年份:
    2006
  • 负责人:
    MARC A OSTERMEIER
  • 依托单位:
Live Cell Fluorescence Imaging Using Molecular Switches
  • 批准号:
    7244060
  • 项目类别:
  • 资助金额:
    $11.63万
  • 财政年份:
    2006
  • 负责人:
    MARC A OSTERMEIER
  • 依托单位:
Creation of site-specific DNA methyltransferases
  • 批准号:
    6856015
  • 项目类别:
  • 资助金额:
    $23.95万
  • 财政年份:
    2005
  • 负责人:
    MARC A OSTERMEIER
  • 依托单位:
Creation of site-specific DNA methyltransferases
  • 批准号:
    7016292
  • 项目类别:
  • 资助金额:
    $19.9万
  • 财政年份:
    2005
  • 负责人:
    MARC A OSTERMEIER
  • 依托单位:
海外基金