Training Grant In Radiation Biology

放射生物学培训补助金

• 批准号: 8697019
• 负责人: MICHAEL L. FREEMAN
• 金额: $ 15.87万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8697019
• 关键词: Grant; Radiobiology; Training

DESCRIPTION (provided by applicant): The American Cancer Association estimates that 1.5 million citizens of the US are diagnosed with cancer each year. Approximately 50% of these cancer patients will undergo radiation therapy, which can provide definitive local regional tumor control, thus affording these patients with a durable progression free survival. Unfortunately, many tumors do not respond to irradiation. Elucidating the molecular mechanisms responsible for radiation therapy's failure to control tumor growth requires a critical understanding of Radiation Biology, a multi- disciplinary science that studies physics, biology, and medicine as it pertains to oncogenesis, tumor biology and normal tissue physiology. As important as Radiation Biology is for supporting Radiation Oncology's mission, there are very few such training programs in this country. The goal of this training grant is to continue to teach Postdoctoral Fellows to perform independent research in the area of Radiation Biology, so that they can make outstanding contributions to the fields of Radiation Oncology and Cancer Biology. We propose to accomplish this using a multi-faceted approach consisting of 1) training in the laboratories of outstanding scientists who utilize cutting edge techniques coupled with highly collaborative approaches, 2) multi- disciplinary seminar series designed to foster interactions between basic scientists and clinician/scientists who perform translational research, 3) didactic training in the areas of Radiation Biology, Radiation Physics, and Cancer Biology, 4) a grant writing workshop, 5) professional development, 6) training in laboratory management, and 7) Training in the Responsible Conduct of Research. Trainees must have completed a MD and/or a PhD prior to entering the program. The program is designed to train 3 Fellows for a duration ranging from 2 to 3 years. It is anticipated that 2 of the trainees will have just completed their PhD or MD and the third trainee will have 2 or 3 years Post Doctoral experience prior to entering our program. To date 70% of trainees who complete training tenure track assistant professors, staff scientists at pharmaceutical companies, or Radiation Oncology Residents on track to attain faculty positions. Of note, 30% of the trainees who have accepted offers to this program have been underrepresented minorities. Based on these successes, we submit that this training grant program is fulfilling the goals of the National Ruth L. Kirschstein National Research Service Award.

描述（由申请人提供）：美国癌症协会估计，每年有150万美国公民被诊断患有癌症。大约50%的这些癌症患者将接受放射治疗，这可以提供明确的局部区域肿瘤控制，从而为这些患者提供持久的无进展生存期。不幸的是，许多肿瘤对辐射没有反应。阐明负责放射治疗未能控制肿瘤生长的分子机制需要对放射生物学的批判性理解，放射生物学是一门研究物理学、生物学和医学的多学科科学，因为它涉及肿瘤发生、肿瘤生物学和正常组织生理学。放射生物学对于支持放射肿瘤学的使命同样重要，在这个国家很少有这样的培训项目。该培训补助金的目标是继续教授博士后研究员在放射生物学领域进行独立研究，使他们能够在放射肿瘤学和癌症生物学领域做出杰出贡献。我们建议使用多方面的方法来实现这一目标，包括：1）在实验室中对利用尖端技术与高度协作方法相结合的杰出科学家进行培训，2）旨在促进基础科学家与进行转化研究的临床医生/科学家之间互动的多学科研讨会系列，3）辐射生物学，辐射物理学，和癌症生物学，4）补助金写作研讨会，5）专业发展，6）实验室管理培训，以及7）负责任的研究行为培训。 学员必须在进入该计划之前完成MD和/或PhD。该方案旨在培训3名研究员，为期2至3年。预计其中2名学员将刚刚完成博士或医学博士学位，第三名学员将在进入我们的项目之前有2或3年的博士后经验。到目前为止，70%完成终身制培训的学员跟踪助理教授，制药公司的科学家，或放射肿瘤学居民有望获得教职。值得注意的是，接受该方案的受训者中有30%是代表性不足的少数民族。基于这些成功，我们认为，这一培训补助金计划是实现国家露丝L。Kirschstein国家研究服务奖。