Workshop on Methods in Supportive Oncology Research

描述（由申请人提供）：本重新提交的R25提案旨在申请癌症教育资助，用于为早期研究人员开发、实施和评估关于支持性肿瘤学研究方法的强化教育研讨会。支持性肿瘤学包括姑息治疗、症状管理、社会心理肿瘤学和幸存者治疗。尽管我们对癌症及其治疗的理解取得了重大进展，但大多数癌症患者仍然遭受疲劳、疼痛、焦虑、失眠、抑郁症状和食欲不振的折磨。这些衰弱症状不仅影响生活质量（QOL），还影响医疗保健的利用、对癌症治疗的依从性，甚至可能影响生存。研究证实了支持性肿瘤学的价值，例如早期姑息治疗的试验显示转移性肺癌患者的生活质量和生存率得到改善。然而，支持肿瘤干预的证据基础仍在不断涌现，需要进一步的研究来指导临床护理。为了解决这一差距，拟议的研讨会响应了国家对培养具有开展支持性肿瘤学高质量研究所需技能的专家科学家的呼吁，目标是NCI八项任务中的四项：1)了解影响癌症结局的因素；2)提高癌症护理质量；3)改善癌症患者、幸存者及其家属的生活质量；4)克服癌症健康差距。方法和背景：在五年的资助期间，来自不同学科（医生、护士、心理学家和社会工作者）的204名早期研究人员将参加在马萨诸塞州总医院（MGH）举行的为期六天的密集研讨会。该研讨会是模仿ASCO-AACR年度临床试验研讨会的成功举办的。研讨会的主要目标是培训支持肿瘤学基本研究方法的早期研究人员，这将使他们能够编写科学合理的研究方案并在美国实施这些方案。在参与者将研究想法发展成完整的研究方案并提交给IRB的过程中，教师将教授并直接指导参与者。参与者将参加有关相关方法的广泛教学会议，并接受生物统计学家和其他教员的个人咨询。教员：为了实现这些目标，我们组建了一个由教员组成的专家团队来计划、制作和评估研讨会，其中包括ASCO-AACR临床试验研讨会的现任联合主席。在MGH建立了一个高生产力和知名的支持性肿瘤研究项目后，PIs (dr。Pirl和Temel拥有组织这次研讨会所需的经验和领导技能。合作组织：为了进一步增加成功的机会，我们与美国癌症协会（ACS）、国家姑息治疗研究中心、马萨诸塞大学波士顿分校/丹娜-法伯哈佛癌症中心U54和MGH ACS机构研究基金合作，以促进研讨会，并帮助确保参与者的多样化和合格来源。

DESCRIPTION (provided by applicant): This resubmitted R25 proposal is for a Cancer Education Grant to develop, implement, and evaluate an intensive educational workshop on research methods in supportive oncology for early-stage investigators. Supportive oncology includes palliative care, symptom management, psychosocial oncology, and survivorship. Despite major advances in our understanding of cancer and its treatment, the majority of individuals with cancer still suffer from fatigue, pain, anxiety, insomnia, depressive symptoms, and poor appetite. Such debilitating symptoms not only affect quality of life (QOL), but also impact healthcare utilization, adherence to cancer treatment, and possibly even survival. Research has confirmed the value of supportive oncology, such as with a trial of early palliative care showing improved QOL and survival for patients with metastatic lung cancer. However, the evidence base for supportive oncology interventions is still emerging, and additional research is necessary to guide clinical care. To address this gap, the proposed workshop responds to national calls for developing expert scientists with the skills needed to conduct high-quality research in supportive oncology, targeting four of the eight missions of the NCI: 1) to understand the factors that influence cancer outcomes; 2) to improve the quality of cancer care; 3) to improve the quality of life for cancer patients, survivors, and their families; and 4) to overcome cancer health disparities. Approach and setting: Over the five years of the grant, 204 early-stage researchers from diverse disciplines (physicians, nurses, psychologists, and social workers) will attend this intensive six-day workshop at the Massachusetts General Hospital (MGH). The workshop is modeled after the successful ASCO-AACR annual workshop on clinical trials. The primary goal of the workshop is train early-stage investigators in essential research methods in supportive oncology, which will enable them to write scientifically sound study protocols and implement these protocols across the US. Faculty will teach and directly mentor participants as they develop a research idea into a completed study protocol of sufficient caliber for submission to an IRB. Participants will attend a broad range of didactic sessions regarding relevant methodologies and receive individual consultations from biostatisticians and other faculty. Faculty: To accomplish these goals, we have assembled an expert team of faculty to plan, produce, and evaluate the workshop, including the current co-chair of the ASCO-AACR clinical trials workshop. Having established a highly-productive and well-known program of supportive oncology research at MGH, the PIs (Drs. Pirl and Temel) possess the requisite experience and leadership skills to organize this workshop. Collaborating organizations: To further increase the chance of success, we have partnered with the American Cancer Society (ACS), National Center for Palliative Care Research, University of Massachusetts, Boston/ Dana-Farber Harvard Cancer Center U54, and the MGH ACS Institutional Research Grant to promote the workshop and to help ensure a diverse and qualified source of participants.