Workshop on Methods in Supportive Oncology Research

描述(由申请人提供)：这份重新提交的R25提案是一项癌症教育补助金，用于为早期研究人员开发、实施和评估关于支持性肿瘤学研究方法的强化教育研讨会。支持肿瘤学包括姑息治疗、症状管理、心理社会肿瘤学和存活率。尽管我们对癌症及其治疗的了解取得了重大进展，但大多数癌症患者仍然患有疲倦、疼痛、焦虑、失眠、抑郁症状和食欲不振。这些衰弱的症状不仅影响生活质量(QOL)，还影响医疗保健利用率、癌症治疗的坚持，甚至可能影响生存。研究证实了支持性肿瘤学的价值，例如，一项早期姑息治疗的试验显示，转移性肺癌患者的生活质量和存活率得到了改善。然而，支持性肿瘤学干预的证据基础仍在不断涌现，有必要进行更多的研究来指导临床护理。为了解决这一差距，拟议的研讨会响应了各国的呼吁，即培养具有开展支持性肿瘤学高质量研究所需技能的专家科学家，目标是NCI的八项任务中的四项：1)了解影响癌症结果的因素；2)提高癌症护理的质量；3)提高癌症患者、幸存者及其家人的生活质量；以及4)克服癌症健康差距。方法和背景：在五年的赠款中，来自不同学科的204名早期研究人员(医生、护士、心理学家和社会工作者)将参加在马萨诸塞州综合医院(MGH)举行的为期六天的密集研讨会。该研讨会是以ASCO-AACR成功举办的临床试验年度研讨会为蓝本。研讨会的主要目标是培训早期研究人员有关支持性肿瘤学的基本研究方法，这将使他们能够编写科学合理的研究方案，并在美国各地实施这些方案。教师将教授和直接指导参与者将研究想法发展为具有足够能力的完整研究方案，以提交给IRB。参与者将参加一系列有关相关方法的教学会议，并接受生物统计学家和其他教员的个别咨询。教员：为了实现这些目标，我们组建了一个教员专家团队来规划、制作和评估研讨会，其中包括ASCO-AACR临床试验研讨会的现任联合主席。在麻省理工学院建立了高生产力和著名的支持性肿瘤学研究计划后，PI(Pirl博士和Temel博士)拥有组织这次研讨会所需的经验和领导技能。合作组织：为了进一步增加成功的机会，我们与美国癌症协会(ACS)、国家姑息治疗研究中心、马萨诸塞州大学、波士顿/达纳-法伯哈佛癌症中心U54和MGH ACS机构研究补助金合作，以促进研讨会并帮助确保参与者的多元化和合格来源。

DESCRIPTION (provided by applicant): This resubmitted R25 proposal is for a Cancer Education Grant to develop, implement, and evaluate an intensive educational workshop on research methods in supportive oncology for early-stage investigators. Supportive oncology includes palliative care, symptom management, psychosocial oncology, and survivorship. Despite major advances in our understanding of cancer and its treatment, the majority of individuals with cancer still suffer from fatigue, pain, anxiety, insomnia, depressive symptoms, and poor appetite. Such debilitating symptoms not only affect quality of life (QOL), but also impact healthcare utilization, adherence to cancer treatment, and possibly even survival. Research has confirmed the value of supportive oncology, such as with a trial of early palliative care showing improved QOL and survival for patients with metastatic lung cancer. However, the evidence base for supportive oncology interventions is still emerging, and additional research is necessary to guide clinical care. To address this gap, the proposed workshop responds to national calls for developing expert scientists with the skills needed to conduct high-quality research in supportive oncology, targeting four of the eight missions of the NCI: 1) to understand the factors that influence cancer outcomes; 2) to improve the quality of cancer care; 3) to improve the quality of life for cancer patients, survivors, and their families; and 4) to overcome cancer health disparities. Approach and setting: Over the five years of the grant, 204 early-stage researchers from diverse disciplines (physicians, nurses, psychologists, and social workers) will attend this intensive six-day workshop at the Massachusetts General Hospital (MGH). The workshop is modeled after the successful ASCO-AACR annual workshop on clinical trials. The primary goal of the workshop is train early-stage investigators in essential research methods in supportive oncology, which will enable them to write scientifically sound study protocols and implement these protocols across the US. Faculty will teach and directly mentor participants as they develop a research idea into a completed study protocol of sufficient caliber for submission to an IRB. Participants will attend a broad range of didactic sessions regarding relevant methodologies and receive individual consultations from biostatisticians and other faculty. Faculty: To accomplish these goals, we have assembled an expert team of faculty to plan, produce, and evaluate the workshop, including the current co-chair of the ASCO-AACR clinical trials workshop. Having established a highly-productive and well-known program of supportive oncology research at MGH, the PIs (Drs. Pirl and Temel) possess the requisite experience and leadership skills to organize this workshop. Collaborating organizations: To further increase the chance of success, we have partnered with the American Cancer Society (ACS), National Center for Palliative Care Research, University of Massachusetts, Boston/ Dana-Farber Harvard Cancer Center U54, and the MGH ACS Institutional Research Grant to promote the workshop and to help ensure a diverse and qualified source of participants.