Workshop on Methods in Supportive Oncology Research

支持性肿瘤学研究方法研讨会

• 批准号: 10250461
• 负责人: WILLIAM F PIRL
• 金额: $ 5.71万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250461
• 关键词: Address; Adherence; Advisory Committees; Affect; American Cancer Society; Anxiety; Behavior; Boston; Cancer Center; Caring; Clinical; Committee Members; Comprehensive Cancer Center; Dana-Farber Cancer Institute; Desire for food; Direct Costs; Discipline; Educational workshop; Ensure; Evaluation; Faculty; Fatigue; Feedback; Fellowship; Funding; General Hospitals; Goals; Grant; Grant Review; Group Meetings; Home; Individual; Institute of Medicine (U.S.); Institution; Intervention; Journals; Knowledge; Leadership; Logistics; Malignant Neoplasms; Massachusetts; Mentors; Mentorship; Methods; Mission; Nurses; Oncology; Outcome; Pain; Palliative Care; Paper; Participant; Physicians; Positioning Attribute; Process; Protocols documentation; Psychologist; Psychosocial Assessment and Care; Publishing; Quality of life; Reaction; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Resources; Scientific Advances and Accomplishments; Sleeplessness; Social Workers; Source; Time; Training; Training Programs; Universities; Writing; anticancer research; cancer therapy; career; clinical care; depressive symptoms; design; disabling symptom; education research; end of life care; evidence base; experience; health care service utilization; innovation; investigator training; lectures; medical schools; member; multidisciplinary; oncology program; palliative; programs; psychologic; psychosocial; skills; statistics; success; survivorship; symptom management; systematic review

PROJECT SUMMARY Despite dramatic advances in the understanding of cancer and its treatment, the majority of individuals with cancer still suffer from fatigue, pain, anxiety, insomnia, depressive symptoms, and poor appetite. These debilitating symptoms not only affect quality of life, but also impact healthcare utilization, adherence to cancer treatment, and possibly even survival. Supportive oncology (palliative care, symptom management, psychosocial oncology, and survivorship) aims to address these concerns. However, the evidence base for supportive oncology interventions is still emerging. Additional research is necessary to guide clinical care and the IOM identified a critical shortage of trained investigators in supportive oncology to meet this need. Responding to national calls to address this gap, we propose to renew our highly successful Cancer Research Education Grant to continue to train new investigators in supportive oncology research. In the last four years, we trained 143 early-career investigators through an annual intensive workshop on research methods in supportive oncology. Participants significantly gained research knowledge and skills, 100% had completed research protocols at the end of the workshop, and over 80% later implemented these protocols at their home institutions. In the three years after the workshop, participants from the first class in 2015 obtained over $21.6 million in research funding (a return of $72 for every dollar of direct costs of the grant that year) and published 21 papers with new collaborators from their workshop class. Demand to participate remains high. Approach and setting: Over five years, we propose to train five classes of early-stage researchers from diverse disciplines (physicians, nurses, psychologists, and social workers) by continuing an annual intensive six-day workshop in Boston with the resources of two Harvard institutions: Massachusetts General Hospital (MGH) and the Dana-Farber Cancer Institute (DFCI). Our institutional commitment is substantial, including the Harvard Medical School Center for Palliative Care assuming the management of workshop logistics. The primary goal of the workshop is to train early-stage investigators in essential research methods in supportive oncology, which will enable them to write scientifically rigorous study protocols and implement these protocols across the US. Each day of the workshop, participants attend didactic sessions on a broad range of relevant methods and meet in small writing groups led by R01-funded supportive oncology investigators. With daily feedback and mentorship, participants write a complete research protocol over the six days. Faculty: We have assembled an outstanding team of experts in supportive oncology (established independent researchers, grant reviewers, and journal editors) to plan, produce, and evaluate the workshop. As leaders of highly-productive and well-known supportive oncology programs at DFCI and MGH, the PIs (Drs. Pirl and Temel) possess the requisite experience and leadership skills to organize this workshop.

项目摘要 尽管对癌症及其治疗的理解有了巨大的进步，但大多数人仍然认为， 癌症患者仍会出现疲劳、疼痛、焦虑、失眠、抑郁等症状，以及食欲不振。这些 使人衰弱的症状不仅影响生活质量，而且还影响医疗保健利用率， 治疗甚至是生存支持性肿瘤学（姑息治疗，症状管理， 心理社会肿瘤学和生存）旨在解决这些问题。然而， 支持性肿瘤干预措施仍在出现。有必要进行更多的研究来指导临床护理， 国际医学研究院发现，在支持性肿瘤学方面，严重缺乏训练有素的研究人员来满足这一需求。 响应国家呼吁，以解决这一差距，我们建议更新我们非常成功的癌症 研究教育补助金，继续培训新的研究人员在支持肿瘤学研究。在过去 四年来，我们通过每年一次的密集研究讲习班培训了143名早期职业研究人员 支持性肿瘤学的方法。参与者显著获得了研究知识和技能，100%的人 在研讨会结束时完成了研究协议，超过80%的人后来在2009年实施了这些协议。 他们的家乡机构。在研讨会后的三年里，2015年第一届学员获得了 超过2160万美元的研究资金（当年赠款的每一美元直接成本回报72美元）， 发表了21篇论文，与他们的研讨班的新合作者。参与的需求仍然很高。 方法和设置：在五年内，我们建议培养五类早期研究人员， 不同学科（医生，护士，心理学家和社会工作者），继续每年密集的 为期六天的研讨会在波士顿举行，由两个哈佛机构提供资源：马萨诸塞州总医院 (MGH)Dana-Farber癌症研究所（DFCI）我们的机构承诺是实质性的，包括 哈佛医学院姑息治疗中心承担车间物流管理。的 研讨会的主要目标是培训早期研究人员的基本研究方法， 肿瘤学，这将使他们能够编写科学严谨的研究方案，并实施这些方案 在美国各地。在讲习班的每一天，参加者都参加关于广泛的相关问题的教学会议。 方法，并在由R 01资助的支持性肿瘤学研究者领导的小型写作小组中会面。与日常 反馈和指导，参与者在六天内编写一份完整的研究协议。 学院：我们已经组建了一个优秀的支持性肿瘤学专家团队（成立于1999年）。 独立研究人员，赠款审查员和期刊编辑）计划，制作和评估研讨会。 作为DFCI和MGH高效和知名的支持性肿瘤学项目的领导者，PI（Drs. Pirl和Temel）拥有组织本次研讨会所需的经验和领导技能。