Interleukin 11 and leukaemia inhibitory factor: important regulators of embryo implantation and placentation

白细胞介素11和白血病抑制因子：胚胎着床和胎盘的重要调节因子

• 批准号: nhmrc : 550905
• 负责人: Prof Evdokia Dimitriadis
• 金额: $ 23.08万
• 依托单位: Prince Henry's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interleukin-11-leukaemia-implantation-placentation/115948
• 关键词: Interleukin; 11; leukaemia; inhibitory; factor

Infertility, spontaneous abortion and pre-eclampsia are major clinical problems. Interleukin (IL)-11 and leukemia inhibitory factor (LIF) are critical for embryo implantation in mice but their roles in women are unknown. I will define their roles in the establishment of pregnancy and provide new critical information on their potential as targets for diagnostic and therapeutic tools for infertility and major diseases associated with pregnancy.

不孕症、自然流产和先兆子痫是主要的临床问题。白细胞介素(IL)-11和白血病抑制因子（LIF）对小鼠胚胎植入至关重要，但它们在女性中的作用尚不清楚。我将定义它们在确定妊娠中的作用，并提供新的关键信息，说明它们作为不孕症和与妊娠相关的主要疾病的诊断和治疗工具的潜力。