Food and Drug Administration Research FERN Chemistry Cooperative Agreement: MN De

明尼苏达州农业部 FDA食品安全和安全监测项目(U18)，蕨类化学实验室 RFA-FD-10-003摘要 摘要 明尼苏达州农业部(MDA)实验室服务部正在提交一份申请，根据 FDA食品安全和安保监测项目(U18)，蕨类化学实验室，如RFD-FD-10-003中宣布的。 设施名称和地址：最负责任的个人： 明尼苏达州农业部，实验室主任加里·霍瓦斯 实验室服务部电话：651-201-6563 罗伯特北街601号 明尼苏达州圣保罗，55155 PD/PI： 主电话：651-201-6010，化学科经理米歇尔·坎贝尔 主要传真：651-201-6106电话：651-201-6575 自2004年以来，丙二醛实验室一直是蕨类微生物和化学实验室。丙二醛实验室处于有利地位， 根据其工作人员的经验和专业知识执行FDA蕨类化学合作协议计划的目标， 设施、设备，并通过持续参与蕨类培训、监督、能力测试和合作 协议计划活动。 在申请包中提交了一份研究计划，其中包括项目说明和支持文件，内容包括： 计划公告中列出的四个关键项目领域 气相色谱-质谱法(GC-MS)在毒物筛选鉴定中的应用 食品中的物质和未知化合物； 液质联用(LC-MS)在毒物筛选和鉴定中的应用 食品中的物质和未知化合物； 电感耦合等离子体质谱在重金属和有毒物质筛选鉴定中的应用 食物中的元素；以及 使用酶联免疫吸附试验(ELISA)和其他基于抗体的分析进行筛选和鉴定 食物中的未知毒素。 公告的研究和相关其他项目信息部分涉及的具体问题包括： 实验室设施和其他资源 实验室人员资格 实验室管理实践 分析食品中未知污染物的实验室专业知识 装备 预算预测 样本分析承诺 研究计划和相关文档响应上面概述的每一项，并演示了MDA化学如何 实验室将为实现FDA关于蕨类的食品安全和安保监测项目(U18)的目标做出贡献 化学实验室。这项合作协议对FDA Fern的预期好处是利用了相当多的经验 以及MDA员工的专业知识，以及通过MDA为Fern提供的重要实验室设施和设备资源。丙二醛 实验室工作人员将能够执行蕨类监测任务、浪涌能力反应、熟练程度测试以及执行 各种食品基质中化学污染物的方法开发、验证和增强活动。 1

Minnesota Department of Agriculture FDA Food Safety and Security Monitoring Project (U18), FERN Chemical Laboratories Abstract for RFA-FD-10-003 ABSTRACT The Minnesota Department of Agriculture (MDA) Laboratory Services Division is submitting an application for consideration under the FDA Food Safety and Security Monitoring Project (U18), FERN Chemical Laboratories, as announced in RFD-FD-10-003. Facility name and address: Most responsible individual: Minnesota Department of Agriculture Gary Horvath, Laboratory Director Laboratory Services Division Phone: 651-201-6563 601 Robert Street North St. Paul, MN 55155 PD/PI: Main Phone: 651-201-6010 Michelle Campbell, Chemistry Section Manager Main Fax: 651-201-6106 Phone: 651-201-6575 The MDA Laboratory has been a FERN microbiology and chemistry laboratory since 2004. The MDA Laboratory is well-positioned to carry out the goals of the FDA FERN chemistry cooperative agreement program in terms of the experience and expertise of its staff, facilities, equipment, and through its on-going participation in FERN training, surveillance, proficiency testing, and cooperative agreement programs activities. A Research Plan with project narrative and supporting documentation is submitted in the application package addressing: Four key project areas outlined in the program announcement Use of Gas Chromatograph - Mass Spectrometry (GC-MS) analysis for the screening and identification of poisons, toxic substances, and unknown compounds in foods; Use of Liquid Chromatograph - Mass Spectrometry (LC-MS) analysis for the screening and identification of poisons, toxic substances, and unknown compounds in foods; Use of Inductively Coupled Plasma - Mass Spectrometry for the screening and identification of heavy metals ands toxic elements in food; and, Use of Enzyme-Linked Immunosorbent Assay (ELISA) and other antibody-based analysis for the screening and identification of unknown toxins in foods. Specific issues addressed in the Research and Related Other Project Information portion of the announcement include: Laboratory Facilities and Other Resources Laboratory Personnel Qualifications Laboratory Management Practices Laboratory Expertise in Analyzing Foods for Unknown Contaminants Equipment Budget Projection Sample Analysis Commitment The research plan and associated documentation responds to each item outlined above, and demonstrates how the MDA Chemistry Laboratory will contribute toward meeting the objectives of the FDA Food Safety and Security Monitoring Project (U18) for FERN Chemical Laboratories. The expected benefit of this cooperative agreement to FDA FERN is to leverage the considerable experience and expertise of the MDA staff, and the significant laboratory facilities and equipment resources available to FERN through MDA. MDA laboratory staff will be able to carry out FERN surveillance assignments, surge capacity response, proficiency tests, as well as, perform method development, validation and enhancement activities for chemical contaminants in a variety of food matrices. 1