A novel implementation and social network strategy for acute pulmonary illnesses

急性肺部疾病的新型实施和社交网络策略

• 批准号: 8714043
• 负责人: Curtis H. Weiss
• 金额: $ 13.49万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-05 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8714043
• 关键词: Accountability; Acute; Acute Lung Injury; Acute respiratory failure; Address; Adopted; Adoption; Adult Respiratory Distress Syndrome; Adverse effects; Attitude; Award; Bioinformatics; Breathing; Clinical Sciences; Clinical Trials; Community Hospitals; Complex; Critical Care; Data Collection; Development Plans; Diagnosis; Disease; Electronic Health Record; Electronics; Environmental air flow; Evidence based intervention; Evidence based practice; Failure; Feedback; Funding; Future; Goals; Grant; Guidelines; Happiness; Health; Healthcare; Incidence; Institutes; Institution; Internal Medicine; Intervention; K-Series Research Career Programs; Knowledge; Learning; Link; Lung; Lung diseases; Mechanical ventilation; Medical; Medicine; Mentors; Mentorship; Methods; Modeling; Morbidity - disease rate; Nurses; Outcome; Pathway Analysis; Patient Care; Patients; Physicians; Pneumonia; Positioning Attribute; Procedures; Process; Protocols documentation; Provider; Reporting; Research; Research Infrastructure; Research Personnel; Science; Scientist; Site; Social Network; Surveys; System; Techniques; Testing; Tidal Volume; Translating; Translational Research; United States National Institutes of Health; Universities; Ventilator; Weaning; awake; base; career; career development; clinical infrastructure; clinical practice; clinical research site; design; electronic data; evidence base; implementation science; improved; innovation; meetings; mortality; multidisciplinary; novel; patient oriented research; programs; public health relevance; research study; respiratory; skills; success; tool; treatment as usual

DESCRIPTION (provided by applicant): This career development award will provide Dr. Curtis Weiss the opportunity to develop as an independent researcher of translating research into clinical practice using implementation science and complex network analysis, and to improve the care of patients with acute pulmonary diseases. The current paradigm of implementation is limited because of an ineffective system of translating evidence-based innovations into clinician practice and a lack of understanding about how clinicians learn about and adopt new therapies. Dr. Weiss will use this award to enhance his existing skills with new skills in implementation science and complex network analysis. These skills will allow him to investigate new implementation methods and a better model of how clinicians learn about and adopt evidence-based innovations. He will achieve these career goals through a career development plan that consists of formal coursework, intensive mentorship, and patient-oriented research. His primary mentor is Dr. David Baker, an expert in implementation science with multiple active NIH grants and an outstanding record of mentoring. His co-mentors include experts in implementation science (Dr. Stephen Persell), complex network analysis (Dr. Luis Amaral, a Howard Hughes Medical Institute Early Career Scientist), and ALI, acute respiratory failure, and critical care outcomes (Dr. Richard Wunderink). This will be accomplished at Northwestern University and collaborating clinical sites. Northwestern provides dedicated support from the Division of Pulmonary and Critical Care Medicine and Department of Internal Medicine; 2) his multidisciplinary team of mentors; 3) numerous courses and professional interactions relevant to his career development, including the Northwestern Clinical and Translational Sciences Institute and the Northwestern Institute on Complex Systems; 4) research infrastructure that includes bioinformatics support to design and implement an electronic health record intervention, as well as an institutional electronic data collection program and biostatistical support; and 5) extensive clinical infrastructure. Dr. Weiss with 1) The overall purpose of the research strategy is to use implementation science and complex network analysis to investigate a comprehensive strategy that implements lung protective ventilation and Awake and Breathing Controlled (ABC) weaning, improving the care of patients with acute lung injury (ALI) and acute respiratory failure, respectively. The study will be conducted at one academic and several community hospitals. Specific Aim One will determine the current rate of utilization of these two therapies and link these rates with physician, nurse, and respiratory therapist (provider) knowledge and attitudes about these therapies. Specific Aim Two will use complex network analysis to identify provider opinion leaders at each institution. Specific Aim Three will be a clinical trial that determines whether a multi-faceted, multidisciplinary intervention comprised of opinion leader learning collaboratives, electronic alerts and reminders, and audit and feedback increases implementation rates of low tidal volume ventilation and ABC weaning compared to usual care.

描述（由申请人提供）：该职业发展奖将为Curtis Weiss博士提供发展成为独立研究人员的机会，利用实施科学和复杂网络分析将研究成果转化为临床实践，并改善急性肺部疾病患者的护理。由于将循证创新转化为临床医生实践的系统无效，以及对临床医生如何学习和采用新疗法缺乏了解，目前的实施范式受到限制。Weiss博士将利用这个奖项来提高他在实施科学和复杂网络分析方面的现有技能。这些技能将使他能够研究新的实施方法和临床医生如何学习和采用循证创新的更好模型。他将通过一个职业发展计划来实现这些职业目标，该计划包括正式的课程学习、密集的指导和以病人为导向的研究。他的主要导师是David Baker博士，他是实施科学方面的专家，拥有多项NIH资助和杰出的指导记录。他的共同导师包括实施科学专家（Stephen Persell博士）、复杂网络分析专家（Howard Hughes医学研究所早期职业科学家Luis Amaral博士）、急性呼吸衰竭专家、重症监护结果专家（Richard Wunderink博士）。这将在西北大学和合作的临床站点完成。西北大学提供肺和重症医学部和内科的专门支持；2)他的多学科导师团队；3)与职业发展相关的众多课程和专业互动，包括西北大学临床与转化科学研究所和西北大学复杂系统研究所；4)研究基础设施，包括生物信息学支持，以设计和实施电子健康记录干预，以及机构电子数据收集计划和生物统计支持；5)广泛的