Normative Wideband Acoustic Immittance Data: Toward Clinical Application

规范宽带声导抗数据：走向临床应用

• 批准号: 8758574
• 负责人: Chris A Sanford
• 金额: $ 14.2万
• 依托单位: IDAHO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8758574
• 关键词: 15 year old; Acoustics; Adult; Age; Age-Years; Antibiotics; Characteristics; Child; Childhood; Clinical; Conductive hearing loss; Data; Databases; Development; Disease; Disease Progression; Ear; External auditory canal; Frequencies; Functional disorder; Future; Goals; Growth; Health Personnel; Individual; Judgment; Life; Link; Literature; Longevity; Measurement; Measures; Medical; Natural History; Operative Surgical Procedures; Otitis Media; Otitis Media with Effusion; Pathology; Property; Reference Standards; Research; Sampling; Solid; Speech Perception; Staging; Subgroup; Testing; Therapeutic; Time; Translations; age group; age related; base; clinical application; design; expectation; improved; infancy; instrument; longitudinal design; middle ear; middle ear disorder; public health relevance; response; senescence; tool; transmission process

DESCRIPTION (provided by applicant): Ear-canal based acoustic measurements known as wideband acoustic immittance (WAI) tests are showing promise as powerful middle-ear assessment tools, with potential for significant advantages over traditional middle-ear assessment measures. Some advantages of WAI include the ability to obtain responses over frequencies important for speech perception (0.25-8 kHz), heightened sensitivity to age-related changes in the acoustic properties of the middle ear, improved sensitivity to a wide variety of middle-ear disorders, and the ability to predict conductive hearing loss (CHL). Furthermore, because medical management decisions (i.e., antibiotics and/or surgery) with some middle-ear disorders are often based on the presence/absence of a conductive hearing loss (CHL), the ability to rely on an accurate, objective middle-ear tests to detect CHL may help restrict the unnecessary use of surgery and/or antibiotics. While identification of maturational effects on WAI for some age groups has brought to light the need to develop age-specific normative data, absence of sufficient study of age-related differences in WAI across a broad age range and a comprehensive normative database severely limits the clinical application of WAI tests. Therefore, the aims of this proposal are to gather WAI data from individuals across a broad age range (6 months to 75 years) to, 1) identify age-related differences in WAI characteristics and build a WAI normative database across a broad age range, 2) Identify longitudinal changes in WAI data for a subgroup of subjects (6 to 11 months) to track middle-ear development with more samples across a time period when the greatest changes in WAI are expected to occur, and 3) describe the natural history of changes in middle-ear function for ears with otitis media with effusion (OME) to determine if distinctive WAI characteristics emerge during the progression of pathology At the completion of the proposed project, it is our expectation that we will have identified ages at which significant maturational effects on WAI are present, established a comprehensive WAI normative database at selected ages from infancy through adulthood, and obtained valuable results on the natural history of OME in children. Inasmuch as WAI has potential to significantly improve our ability to identify middle-ear dysfunction and predict CHL, having a normative database to provide context with which to interpret WAI measurements from ears with middle-ear disorders will be a significant step forward in enhancing the clinical utility of WAI tests.

描述（由申请人提供）：基于耳道的声学测量（称为宽带声导抗（阿威）测试）显示出作为强大的中耳评估工具的前景，与传统的中耳评估措施相比具有显着优势。阿威的一些优点包括获得对语音感知重要的频率（0.25-8 kHz）的响应的能力，对中耳声学特性中与年龄相关的变化的灵敏度提高，对各种中耳疾病的灵敏度提高，以及预测传导性听力损失（CHL）的能力。此外，由于医疗管理决策（即，抗生素和/或手术）与一些中耳疾病的关系通常基于传导性听力损失（CHL）的存在/不存在，依靠准确、客观的中耳测试来检测CHL的能力可能有助于限制不必要的手术和/或抗生素的使用。虽然一些年龄组的阿威的成熟效应的识别带来了光需要开发特定年龄的规范性数据，阿威在广泛的年龄范围和一个全面的规范性数据库的年龄相关的差异缺乏足够的研究严重限制了阿威测试的临床应用。因此，该提案的目的是从广泛的年龄范围内的个人收集阿威数据（6个月至75岁），1）确定阿威特征中与年龄相关的差异，并在广泛的年龄范围内建立阿威规范数据库，2）识别受试者亚组的阿威数据的纵向变化（6至11个月），以便在阿威预计发生最大变化的时间段内使用更多样本跟踪中耳发育，描述渗出性中耳炎中耳功能变化的自然史以确定在病理学进展过程中是否出现独特的阿威特征在所提出的项目完成时，我们期望我们将已经确定对阿威存在显著成熟效应的年龄，建立了从婴儿期到成年期的选定年龄的全面阿威规范数据库，并获得了有关儿童OME自然史的有价值结果。由于阿威有可能显着提高我们识别中耳功能障碍和预测CHL的能力，因此拥有一个规范的数据库来提供解释中耳疾病耳朵阿威测量的背景，将是提高阿威测试临床实用性的重要一步。