课题基金 / 基金详情

项目摘要

项目成果

THOMAS D sargent的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The neural crest (NC) plays a critical role in the developmental of the vertebrate head, face and jaws, providing the bulk of the craniofacial skeleton as well as peripheral nervous system and other cranial tissues. Normal craniofacial development depends on proper induction, migration and differentiation of NC cells and derivatives. Deficiencies at any of these steps, whether due to intrinsic defects in NC itself, or in failure of NC cells to interact properly with adjacent tissues, can lead to birth defects: up to a third of all congenital malformations are craniofacial in nature and mostly due to such NC failures. We have used the frog Xenopus and the freshwater tropical fish Danio rerio(zebrafish)as experimental model organisms to study NC development. The starting point for this project was two transcription factors, TFAP2a and Dlx3, the regulation of which we showed several years ago to be critical for the early steps in NC development. We are now designing, establishing and using transgenic zebrafish lines expressing both wild-type and mutated versions of these factors, followed by morphological and gene expression analysis, to identify target genes for these factors, and also to study their function in later stages of neural crest migration and terminal differentiation. Our goal is to relate the regulation of specific genes by TFAP2 and Dlx factors to cranifacial development in human embryos, both normal and pathological, hoping to establish diagnostic tools and, eventually, therapeutic strategies for preventing and treating cranifacial dysmorphology, the most common form of birth defects in human infants.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Protein /Nucleic Acid Interactions In Embryogenesis
Protein/nucleic Acid Interactions In Vertebrate Embryoge
Protein/nucleic Acid Interactions In Vertebrate Embryoge
Protein/nucleic Acid Interactions In Vertebrate Embryoge
海外基金