MBCT effects on brain mechanisms of interoceptive awareness and rumination in MDD

MBCT 对 MDD 内感受意识和沉思大脑机制的影响

• 批准号: 8679696
• 负责人: Gaelle Desbordes
• 金额: $ 13.72万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8679696
• 关键词: Address; Amygdaloid structure; Anxiety; Area; Arousal; Attention; Autonomic nervous system; Awareness; Brain; Brain imaging; Brain region; Clinical; Clinical Trials; Cognitive; Control Groups; Cross-Sectional Studies; Development; Development Plans; Disease; Emotional; Emotions; Engineering; Feeling; Functional Magnetic Resonance Imaging; Health; Individual; Insula of Reil; Intervention; Investigation; Knowledge; Learning; Light; Link; Major Depressive Disorder; Measurable; Measures; Meditation; Mental Health; Mentored Research Scientist Development Award; Mentors; Mind; Mind-Body Intervention; Modeling; Neurosciences; Outcome; Participant; Patients; Physiological; Public Health; Randomized; Regulation; Relapse; Research; Research Personnel; Scientist; Structure; Symptoms; Testing; Training; Training Support; Work; base; body-mind; burden of illness; career development; cingulate cortex; clinical application; depressive symptoms; design; disability; effective therapy; experience; flexibility; group intervention; heart rate variability; improved; mindfulness; mindfulness based cognitive therapy; mortality; negative mood; neuroimaging; prevent; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development (K01) Award will support the training and career development of a junior investigator with prior training in neuroscience and engineering, transitioning into the field of meditation brain imaging research. The proposed career development plan includes training in mind-body medicine, clinical trials, mental health, neuroimaging, and meditation-based interventions for clinical applications. The proposed research focuses on the neural and physiological mechanisms of mindfulness-based cognitive therapy (MBCT), an effective group intervention for major depressive disorder (MDD). MDD is characterized by maladaptive rumination-a persistence of negative, self-focused mind states. The MBCT framework holds that ruminative tendencies can be remediated by using mindfulness practice to facilitate an earlier recognition of unpleasant mind states and internal feelings that usually trigger rumination, thereby enabling disengagement from the subsequent downward spiral into negative moods typical of MDD. Previous studies (including recent work by the Applicant) suggest that mindfulness-based interventions have measurable effects on brain structure and function, especially in brain regions known to be dysfunctional in MDD, and that meditation training may improve autonomic regulation of cardiorespiratory function, as assessed with measures of heart rate variability (HRV). However, the specific mechanisms of action of MBCT in MDD are currently unknown. In this study we will use functional magnetic resonance imaging (fMRI) and autonomic (HRV) assessments (i) to investigate the longitudinal effects of MBCT on the brain networks involved with interceptive awareness and rumination and on the autonomic nervous system, and (ii) to test the proposed mechanism that increased interceptive brain activation after MBCT improves participant ability to disengage from ruminative brain activity, thereby reducing depressive symptoms. The findings from the proposed research will shed light on the neural and physiological mechanisms of action of MBCT in major depression.

描述(由申请者提供)：这个指导研究科学家发展(K01)奖将支持初级研究员的培训和职业发展，之前曾接受过神经科学和工程方面的培训，过渡到冥想脑成像研究领域。拟议的职业发展计划包括心身医学、临床试验、心理健康、神经成像和基于冥想的临床应用干预方面的培训。这项拟议的研究重点是基于正念的认知疗法(MBCT)的神经和生理机制，这是一种有效的团体干预严重抑郁障碍(MDD)的方法。MDD的特征是不适应沉思--一种持续的消极的、自我关注的精神状态。MBCT框架认为，沉思倾向可以通过使用正念练习来补救，以促进对通常会引发沉思的不愉快心理状态和内部感觉的更早认识，从而使其能够从随后的螺旋式下降中解脱出来，进入MDD典型的负面情绪。以前的研究(包括申请人最近的工作)表明，基于正念的干预对大脑结构和功能有可测量的影响，特别是在已知的MDD大脑区域，冥想训练可以改善心肺功能的自主神经调节，通过心率变异性(HRV)的测量进行评估。然而，MBCT在MDD中的具体作用机制目前尚不清楚。在本研究中，我们将使用功能磁共振成像(FMRI)和自主神经(HRV)评估(I)来研究MBCT对参与拦截意识和冥想的脑网络以及自主神经系统的纵向影响，以及(Ii)测试MBCT后增加拦截性脑激活的拟议机制，该机制可改善参与者摆脱沉思脑活动的能力，从而减少抑郁症状。这项拟议研究的结果将有助于阐明MBCT在重度抑郁症中的神经和生理作用机制。