Studies to Evaluate Cardiotoxic Disease Process in Three Strains of Mice Exposed

评估三种暴露小鼠品系的心脏毒性疾病过程的研究

• 批准号: 8845106
• 负责人: LU TAYLOR
• 金额: $ 24.4万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-03 至 2015-02-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8845106
• 关键词: Acute; Adverse effects; Body Temperature; Caffeine; Cannulations; Cardiotoxicity; Chemicals; Chronic; Clinical Chemistry; Contracts; Data; Development; Disease; Dose; Electrocardiogram; Electrophysiology (science); Ensure; Environmental Exposure; Ephedrine; Evaluation; Exposure to; Genes; Goals; Hazard Identification; Hazardous Chemicals; Health; Heart; Heart Rate; Heightened Cancer Risk; Hematology; Histopathology; Human; Insertional Mutagenesis; Intraperitoneal Injections; Life; Measurement; Measures; Methane; Mouse Strains; Mus; National Toxicology Program; Oral Administration; Outcome; Pattern; Perinatal; Phenotype; Process; Ramp; Rat Strains; Reporting; Risk Assessment; Risk Factors; Route; Science; Specific qualifier value; Telemetry; Testing; Tissue-Specific Gene Expression; Toxic effect; Toxicity Tests; Transcript; Water; cohort; disorder prevention; feeding; male; postnatal; public health research; sound

The goal of both of these contracts are to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. These contracts contribute to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. Both of these contracts are used for determining the toxicological potential of selected test agents for the National Toxicology Program (NTP). This contract is used for determining the toxicological potential of selected test agents for the National Toxicology Program (NTP). A combination of any of the following studies may be conducted using these contracts. They are: Acute studies, Prechronic and chronic studies (14-day, 28-day, and 90-day, and two year studies in various strains of rats and mice), Perinatal studies with gestational and postnatal exposure, studies to evaluate QT Prolongation via implantable telemetry. Some of the examples of the endpoints evaluated in these studies are: Histopathology, Differential Gene Expression using Microarray, Insertional mutagenesis, Clinical Chemistry, Hematology, QPCR etc. The routes of administration are oral (gavage, dosed water and dosed feed), IV and IP injections, and submandibular cannulation.

这两份合同的目标都是为国家毒理学计划 (NTP) 危害识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不利影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于识别对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学品。这些合同通过提供所研究化学品的特性、给药剂量水平的确认以及内部剂量测定，有助于毒性研究提供癌症风险升高的证据以及其他毒理学结果。这些信息对于评估毒性测试以及得出有关研究化学品在测试物种中的潜在毒性的合理、科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。利用本合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解因接触所研究化学品而产生的风险因素。 这两份合同均用于确定国家毒理学计划 (NTP) 选定测试剂的毒理学潜力。 该合同用于确定国家毒理学计划 (NTP) 选定测试剂的毒理学潜力。可以使用这些合同进行以下任何研究的组合。它们是：急性研究、慢性前期和慢性研究（在不同品系的大鼠和小鼠中进行的 14 天、28 天、90 天和两年研究）、妊娠和产后暴露的围产期研究、通过植入式遥测评估 QT 延长的研究。这些研究中评估的一些终点示例包括：组织病理学、使用微阵列的差异基因表达、插入诱变、临床化学、血液学、QPCR 等。给药途径为口服（灌胃、定量水和定量饲料）、IV 和 IP 注射以及颌下插管。