Study of Novel Influenza C Virus
新型丙型流感病毒的研究
基本信息
- 批准号:8702788
- 负责人:
- 金额:$ 21.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-15 至 2016-07-31
- 项目状态:已结题
- 来源:
- 关键词:Amino Acid SequenceAnimalsAntibodiesBiologicalBiological AssayBiologyCattleCell Culture TechniquesCellsClassificationCodeCoupledDevelopmentDideoxy Chain Termination DNA SequencingEvolutionExhibitsFamily suidaeFerretsFoundationsGeneticGenomic SegmentGoalsGoldGrowthHealthHumanHuman VirusIn VitroIncidenceInfectionInfluenzaInfluenza A virusInfluenza C VirusInvestigationLivestockLung diseasesMethodsMolecularMolecular GeneticsMutationNucleoproteinsOklahomaOrthomyxoviridaePhylogenetic AnalysisPorcine Influenza A VirusPrevalencePropertyProteinsRNA SequencesRNA SplicingRespiratory Tract DiseasesReverse Transcriptase Polymerase Chain ReactionRoleSequence AnalysisSerologicalSerumSurveysSystemTechniquesTemperatureTropismVariantViralVirionVirusVirus ReplicationWorkexperiencegenetic evolutiongenome sequencinghemagglutinin esterasehemagglutinin esterase fusion proteininfluenzavirusinsightnovelnovel viruspathogenpositional cloningpublic health relevancereceptorreceptor bindingrespiratoryswine influenzatooltransmission process
项目摘要
DESCRIPTION (provided by applicant): The Orthomyxoviruses have three types of influenza viruses, termed as A, B, and C, that are classified according to the antigenic differences between their nucleoprotein (NP) and matrix 1 (M1) proteins as demonstrated in the traditional serological assays. We identified a novel influenza virus from swine exhibiting influenza-like illness. Its overall amino acid sequence shares approximately 50 % identity with that of ICV. Phylogenetic analysis further found that it is most closely related to ICV, rather than to IAV and IBV. However, the distance between the new virus and ICV was similar to the differences between IAV and IBV for the most of genomic segments. Recently, we also found the prevalence of C/OK-like virus in cattle. The incidences of C/OK and C/OK-like viruses in both cattle and swine provides strong evidence of cross-species transmission, highlighting their potential threat to human health because of closely physical contacts between humans and these farm animals. Additionally, this group of viruses may undergo reassortment with currently circulating human ICV to generate new antigenic variants that could pose a threat to human and animal health. The potential impact on human health and the novel properties in biology and molecular genetics warrant further investigation into this group of new viruses, which form the foundation of this R21 proposal. Major goals of this R21 project are to develop reverse genetics systems (RGS) for these novel viruses, identify their receptor, elucidate a functional role of vira HE protein in cell tropism and temperature restriction of virus replication, define viral mutation rates, and importantly determine whether human ICV and these new viruses can undergo reassortment to produce viable viruses. Successful completion of this project will provide novel insights to evolution, biology, and genetics of this new group of emerging viruses that have a potential threat to human health.
描述(由申请方提供):正粘病毒有三种类型的流感病毒,称为A、B和C,根据其核蛋白(NP)和基质1(M1)蛋白之间的抗原差异进行分类,如传统血清学试验所示。我们从表现出流感样疾病的猪中鉴定出一种新型流感病毒。其全部氨基酸序列与ICV的氨基酸序列具有约50%的同一性。系统发育分析进一步发现,它与ICV的关系最密切,而不是与IAV和IBV的关系。但在大部分基因组片段上,新病毒与ICV之间的距离与IAV和IBV之间的差异相似。近年来,我们也发现了牛中C/OK样病毒的流行。牛和猪中C/OK和C/OK样病毒的发生提供了跨物种传播的强有力证据,突出了它们对人类健康的潜在威胁,因为人类与这些农场动物之间有密切的身体接触。此外,这组病毒可能会与目前流行的人类ICV发生重配,产生新的抗原变体,可能对人类和动物健康构成威胁。对人类健康的潜在影响以及生物学和分子遗传学上的新特性保证了对这组新病毒的进一步研究,这构成了R21提案的基础。该R21项目的主要目标是为这些新型病毒开发反向遗传学系统(RGS),鉴定其受体,阐明病毒HE蛋白在病毒复制的细胞嗜性和温度限制中的功能作用,定义病毒突变率,并重要地确定人类ICV和这些新病毒是否可以进行重配以产生活病毒。该项目的成功完成将为这组对人类健康有潜在威胁的新病毒的进化、生物学和遗传学提供新的见解。
项目成果
期刊论文数量(0)
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{{ truncateString('FENG LI', 18)}}的其他基金
A novel assay for inhibitors of influenza A virus polymerase complex assembly
甲型流感病毒聚合酶复合物组装抑制剂的新测定法
- 批准号:
7921295 - 财政年份:2009
- 资助金额:
$ 21.5万 - 项目类别:
Mechanism of action of an HIV-1 maturation inhibitor
HIV-1 成熟抑制剂的作用机制
- 批准号:
8304325 - 财政年份:2008
- 资助金额:
$ 21.5万 - 项目类别:
Mechanism of action of an HIV-1 maturation inhibitor
HIV-1 成熟抑制剂的作用机制
- 批准号:
7683909 - 财政年份:2008
- 资助金额:
$ 21.5万 - 项目类别:
Mechanism of action of an HIV-1 maturation inhibitor
HIV-1 成熟抑制剂的作用机制
- 批准号:
8110561 - 财政年份:2008
- 资助金额:
$ 21.5万 - 项目类别:
A novel assay for inhibitors of influenza A virus polymerase complex assembly
甲型流感病毒聚合酶复合物组装抑制剂的新测定法
- 批准号:
7533709 - 财政年份:2008
- 资助金额:
$ 21.5万 - 项目类别:
Mechanism of action of an HIV-1 maturation inhibitor
HIV-1 成熟抑制剂的作用机制
- 批准号:
7496229 - 财政年份:2008
- 资助金额:
$ 21.5万 - 项目类别:
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