Intracellular trafficking of copper and platinum-based chemotherapuetics

铜和铂基化疗药物的细胞内运输

• 批准号: nhmrc : 606609
• 负责人: Dr Richard Burke
• 金额: $ 17.89万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intracellular-trafficking-copper-based-chemotherapuetics/78494
• 关键词: Intracellular; trafficking; copper; platinum; based

Platinum-based anti cancer drugs such as Cisplatin are effective against a number of cancers of the head, colon, lungs and ovaries. Tumour resistance to these drugs has been closely associated with changes in genes that control the movement of copper in and out of cells. We hypothesize that the same genes regulate distribution of both copper and Cisplatin. By investigating these pathways, we aim to find ways to predict and prevent tumour resistance to this important anti cancer treatment.

以铂为基础的抗癌药物，如顺铂，对许多头部、结肠、肺部和卵巢的癌症有效。肿瘤对这些药物的耐药性与控制铜进出细胞的基因变化密切相关。我们假设相同的基因调节铜和顺铂的分布。通过研究这些途径，我们的目标是找到预测和预防肿瘤对这种重要抗癌治疗耐药性的方法。