Intranasal naloxone for the reversal of opioid overdose: A double-blinded, double-dummy controlled non-inferiority trial in Sydney’s Medically Supervised Injecting Centre

鼻内纳洛酮逆转阿片类药物过量：在悉尼医疗监督注射中心进行的双盲、双模拟对照非劣效性试验

• 批准号: nhmrc : GNT1157452
• 金额: $ 79万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intranasal-naloxone-reversal-injecting-centre/1378987
• 关键词: Intranasal; naloxone; reversal; opioid; overdose

The intranasal administration of naloxone confers many advantages over other routes of administration, particularly in relation to take home naloxone (THN) as it avoids complications with the use of needles such as the risks of needle-stick injury and requires less training. New data suggests that it may be as effective as intramuscular naloxone.We will test this hypothesis in a non-inferiority controlled trial conducted in clinical practice at the Sydney Medically Supervised Injecting Centre.

纳洛酮的鼻内给药比其他给药途径具有许多优点，特别是关于带回家纳洛酮（THN），因为它避免了使用针头的并发症，例如针刺损伤的风险，并且需要较少的培训。新的数据表明，它可能是有效的肌肉注射纳洛酮。我们将测试这一假设在非劣效性对照试验中进行的临床实践中，在悉尼医学监督注射中心。