UnityPhilly Response App for Overdose Reversal: Assessing Citywide Effectiveness and Sustainability
UnityPhilly 逆转用药过量响应应用程序:评估全市范围的有效性和可持续性
基本信息
- 批准号:10585638
- 负责人:
- 金额:$ 97.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-30 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdoptionAfrican American populationCOVID-19 impactCOVID-19 pandemicCessation of lifeCitiesCommunitiesDiseaseEffectivenessEmergency SituationEnrollmentEnsureEnvironmentEpidemicEquityEventFamily memberFeasibility StudiesFentanylGoalsGovernment AgenciesHealthHeroinInterventionLatinxLinkLocal GovernmentMaintenanceMedicalMissionModelingNaloxoneNeighborhoodsOutcomeOutcome MeasureOverdoseOverdose reductionOverdose reversalParticipantPathway interactionsPatternPersonsPhiladelphiaPopulationProcessPsyche structurePublic HealthReach, Effectiveness, Adoption, Implementation, and MaintenanceRecoveryResearchSignal TransductionSpeedSubgroupUnited States National Institutes of Healthbehavioral studycommunity organizationsdesignexperienceimprovedinnovationinsightmanufacturemembermortalityopioid epidemicopioid misuseopioid mortalityopioid overdoseopioid useoverdose deathoverdose riskpilot testprescription opioidpublic health interventionpublic health prioritiesresponsescale upsmartphone applicationsynthetic opioiduptakeurban settingusabilityvolunteerwillingness
项目摘要
PROJECT SUMMARY/ABSTRACT
Reducing overdose mortality immediately and long-term is a top public health priority as the overdose epidemic
in the U.S. continues to worsen. The COVID-19 pandemic, which began hitting the U.S. in early 2020, has
exacerbated the overdose crisis - particularly among African Americans and Latinxs. Opioid overdose deaths,
which accounted for the most overdose deaths in 2020, continue to drive the epidemic. Overdose deaths linked
to synthetic opioids, such as illicitly manufactured fentanyl, have increased significantly and comprised most of
the opioid-related deaths in 2020. Despite increasing availability and acceptability of naloxone among
laypersons, opioid overdose deaths remain catastrophically high in communities across the U.S. The UnityPhilly
smartphone app was developed in 2018-19 alongside several community-based organizations as a public health
intervention in response to the opioid overdose crisis in Philadelphia, which has the most acute overdose
epidemic among large cities in the U.S. UnityPhilly automatically connects bystanders and victims of opioid
overdose with nearby community members who can respond immediately with naloxone. The objective of this
proposal, following a successful feasibility study (R34) and clear evidence of overdose reversal supported by
UnityPhilly, is to create an easy-to-use, effective, sustainable, and scalable smartphone app to be deployed
across the city of Philadelphia. This objective will be achieved by studying subgroups of people equipped with
naloxone and UnityPhilly (n=450) and disseminating UnityPhilly to 3,000 citizen volunteers for everyday use to
respond to opioid overdose emergencies. The long-term goal of this research is to create a scalable app that
can be disseminated to communities across the U.S. experiencing high levels of opioid overdose death. The
rationale for this study is that expanding the availability of the UnityPhilly app to laypersons citywide will increase
the speed and delivery of naloxone to opioid overdose events across Philadelphia while laying the groundwork
for scalability and broader national uptake. Our goals will be achieved with three specific aims: 1) Redevelop
UnityPhilly to ensure ease of use; 2) Assess differences in the effectiveness of UnityPhilly across varied urban
environments and participant profiles; and 3) Build and study a sustainable environment for UnityPhilly to expand
city-wide. This 5-year study will have significant impact by providing actionable evidence regarding the
effectiveness of an app-based naloxone intervention to scale up for nationwide use. The study will be conducted
in partnership with long-standing community-based organizations to ensure usability and acceptability. This
intervention is highly significant since it directly addresses one of the most significant public health problems in
the U.S. – the opioid overdose epidemic – which is worsening due to the effects of COVID-19. This intervention
is highly innovative as it improves upon a previous developed successful mobile phone app and expands its use
to a broader population of users in a large city most impacted by the opioid crisis.
项目总结/摘要
立即和长期减少过量死亡率是公共卫生的首要任务,因为过量流行病
美国的情况继续恶化。2020年初开始袭击美国的COVID-19大流行,
加剧了过量用药的危机,特别是在非洲裔美国人和拉丁美洲人中。阿片类药物过量死亡,
2020年过量死亡人数最多的地区,继续推动这一流行病。过量死亡与
合成阿片类药物,如非法制造的芬太尼,已显着增加,其中大部分是
2020年阿片类药物相关死亡人数尽管纳洛酮的可用性和可接受性在
外行,阿片类药物过量死亡仍然是灾难性的高在美国各地的社区。
智能手机应用程序是在2018-19年与几个社区组织一起开发的,作为公共卫生
针对费城阿片类药物过量危机的干预措施,费城的阿片类药物过量最严重。
美国大城市中的流行病UnityPhilly自动连接旁观者和阿片类药物的受害者
与附近的社区成员谁可以立即与纳洛酮反应过量。的目的
在成功的可行性研究(R34)和明确的药物过量逆转证据支持下,
UnityPhilly的目标是创建一个易于使用、有效、可持续和可扩展的智能手机应用程序,
穿过费城这一目标将通过研究配备有
纳洛酮和UnityPhilly(n=450),并向3,000名公民志愿者分发UnityPhilly,供日常使用,
应对阿片类药物过量紧急情况。这项研究的长期目标是创建一个可扩展的应用程序,
可以传播到美国各地经历高水平阿片类药物过量死亡的社区。的
这项研究的理由是,扩大UnityPhilly应用程序的可用性,以全市范围内的外行将增加
纳洛酮在费城阿片类药物过量事件中的速度和交付,
可扩展性和更广泛的国家吸收。我们的目标将通过三个具体目标实现:1)重建
UnityPhilly以确保易用性; 2)评估UnityPhilly在不同城市的有效性差异
环境和参与者概况; 3)建立和研究一个可持续的环境,为团结费城扩大
全市范围内这项为期5年的研究将通过提供有关
基于应用程序的纳洛酮干预措施的有效性,以扩大全国范围的使用。本研究的开展将
以确保可用性和可接受性。这
干预是非常重要的,因为它直接解决了一个最重要的公共卫生问题,
美国-阿片类药物过量流行病-由于COVID-19的影响正在恶化。这种干预
是高度创新的,因为它改进了以前开发的成功的移动的手机应用程序,并扩大了其使用
在一个受阿片类药物危机影响最大的大城市,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Stephen E Lankenau其他文献
S144 - “If You Go in With a Plan and a Goal, It Can Be Therapeutic”: A Qualitative Exploration of Psychedelic Use Among Emerging Adult Cannabis Users in Los Angeles
S144 - “如果你带着计划和目标去使用,它可能具有治疗作用”:对洛杉矶新兴成年大麻使用者中迷幻剂使用的定性探索
- DOI:
10.1016/j.drugalcdep.2024.111564 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:3.600
- 作者:
Bridgid Conn;Meagan Suen;Kaia L. Sheean;Janna Ataiants;Ekaterina Fedorova;Stephen E Lankenau;Carolyn F. Wong - 通讯作者:
Carolyn F. Wong
Stephen E Lankenau的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Stephen E Lankenau', 18)}}的其他基金
Piloting a naloxone intervention in an emergency response community to reduce opioid overdoses in Philadelphia
在费城的应急响应社区试点纳洛酮干预措施,以减少阿片类药物过量
- 批准号:
9403417 - 财政年份:2017
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults & Community: Connecting Health and Policy
医用大麻,新兴成人
- 批准号:
8685230 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults & Community: Connecting Health and Policy
医用大麻,新兴成人
- 批准号:
9228355 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults & Community: Connecting Health and Policy
医用大麻,新兴成人
- 批准号:
8813547 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults, and Community: Connecting Health and Policy
医用大麻、新兴成年人和社区:连接健康和政策
- 批准号:
10207574 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults, and Community: Connecting Health and Policy
医用大麻、新兴成年人和社区:连接健康和政策
- 批准号:
10439715 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults & Community: Connecting Health and Policy
医用大麻,新兴成人
- 批准号:
8816603 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults & Community: Connecting Health and Policy
医用大麻,新兴成人
- 批准号:
8503943 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Medical Marijuana, Emerging Adults, and Community: Connecting Health and Policy
医用大麻、新兴成年人和社区:连接健康和政策
- 批准号:
9793996 - 财政年份:2013
- 资助金额:
$ 97.99万 - 项目类别:
Evaluation of Overdose Prevention Programs for Injection Drug Users
注射吸毒者过量预防方案的评价
- 批准号:
7686401 - 财政年份:2009
- 资助金额:
$ 97.99万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 97.99万 - 项目类别:
Research Grant