Frontiers in Macromolecular Simulations Symposium

高分子模拟前沿研讨会

• 批准号: 8626415
• 负责人: Jere P Segrest
• 金额: $ 4万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-11 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8626415
• 关键词: Address; Alabama; Algorithms; Applications Grants; Biochemistry; Biological; Biological Sciences; Biology; Biomedical Engineering; Biomedical Research; Biophysics; California; Canada; Caring; Cell membrane; Chemistry; Chicago; Commit; Computers; Databases; Development; Disabled Persons; Electronic Mail; Environment; Enzymes; Family; Feedback; Finland; France; Generations; Genetic Transcription; Goals; Gray unit of radiation dose; Human Genome; Illinois; Individual; Institutes; Investigation; Journals; Lipoproteins; Medical; Membrane; Membrane Proteins; Minority; Molecular; Molecular Biology; Molecular Computers; Molecular Genetics; Molecular Models; Newsletter; North Carolina; Pharmaceutical Preparations; Pharmacology; Physics; Procedures; Process; Protein Dynamics; Proteins; Pump; RNA; Research; Research Personnel; Resources; Ribosomal RNA; Ribosomes; Scientist; Senior Scientist; Series; Signal Pathway; Site; Societies; Structural Biochemistry; Structural Biologist; Structure; Suggestion; System; Technology; Texas; Thinking; Time; Translations; Universities; Washington; Woman; Work; abstracting; base; biological research; computerized tools; drug discovery; falls; frontier; interest; macromolecule; medical schools; meetings; models and simulation; molecular modeling; multidisciplinary; professor; programs; protein folding; receptor; simulation; symposium; theories; transcription factor; web site

DESCRIPTION (provided by applicant): 21st century biomedical research is being driven by the need for new drugs and procedures for solving humankind's most persistent and difficult medical problems. This research critically depends upon computer- intensive structure-based approaches to understand biological macromolecules and supramolecular assemblies in atomic detail. Progress is accelerating at a dizzying rate, and there is a critical need to promote integrative approaches driven by computational structural biologists. To help meet this challenge, our goal is to provide an environment for broadening the thinking of senior scientists, and, more important, to create a new diverse generation of theory-driven integrative scientists studying the structure and dynamics of proteins, membranes, lipoproteins, RNA and ribosomes. In this dual PI grant application, Jere Segrest (UAB) and Steve Harvey (Georgia Tech) are seeking 3 years support for an ongoing annual symposium entitled, "Frontiers in Macromolecular Simulations" that was held for the 6th time in the fall of 2009. For the past four years, the site of this symposium has alternated between UAB in Birmingham, AL and Georgia Tech in Atlanta, GA. The objective of our dual PI grant application is to hold a series of three annual conferences dedicated to fast breaking research in structure and dynamics of membranes, lipoproteins, proteins, RNA and ribosomes. Presentations at the proposed symposia will focus on theory-driven physics-based molecular modeling, simulations and experimentation. Biological research is increasingly multidisciplinary, and many experimental groups now routinely use sophisticated computational tools in their work. Our aim is to provide a venue in which application-oriented computational structural biologists will be exposed to the latest methodological advances (and provide feedback on suggested improvements), and in which experimentalists will have the opportunity to stimulate the thinking of computational biologists, both those who are primarily interested in applications, and those whose primary interest is the development of algorithms. We propose to hold the first of the three planned annual conferences for three days in March 30-April 1, 2011 at the Grand Hotel Marriott, Point Clear, Alabama. Approximately two-thirds of the platform speaker's slots will be reserved for membranes, lipoproteins and proteins and one-third for RNA and ribosomes. The two keynote speakers, Harry Gray, Professor of Chemistry, California Institute of Technology and Rachel Green, Professor of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, have agreed to join the two PIs in the organizing committee for the first conference. In addition to the keynote speakers, nine platform speakers, four women and one minority, have committed for the 2011 symposium. The second in the planned series of three conferences will be held off the Georgia Tech campus in the spring of 2012 at a still to be determined site in the State of Georgia. The final conference in the series will be held in the spring of 2013 at a neutral to be determined site in a third state, not necessarily in the Southeast.

描述（由申请人提供）：21世纪世纪的生物医学研究是由对新药物和新方法的需求驱动的，这些药物和新方法用于解决人类最持久和最困难的医学问题。这项研究严重依赖于计算机密集的结构为基础的方法来理解生物大分子和超分子组装的原子细节。进展正在以令人眼花缭乱的速度加速，迫切需要促进由计算结构生物学家驱动的综合方法。为了帮助应对这一挑战，我们的目标是提供一个环境，拓宽高级科学家的思维，更重要的是，创造一个新的多样化的一代理论驱动的综合科学家研究蛋白质，膜，脂蛋白，RNA和核糖体的结构和动力学。在这个双PI赠款申请，杰尔Segrest（UAB）和史蒂夫哈维（格鲁吉亚技术）正在寻求3年的支持，为正在进行的年度研讨会，题为“前沿的高分子模拟”，这是在2009年秋季举行的第6次。在过去的四年里，这个研讨会的地点在阿拉巴马州伯明翰的UAB和佐治亚州亚特兰大的格鲁吉亚理工学院之间交替举行。我们的双PI赠款申请的目的是举行一系列的三个年度会议，致力于在膜，脂蛋白，蛋白质，RNA和核糖体的结构和动力学的快速突破研究。在拟议的研讨会上的演讲将集中在理论驱动的基于物理的分子建模，模拟和实验。生物学研究越来越多地涉及多学科，许多实验小组现在经常在工作中使用复杂的计算工具。我们的目标是提供一个场所，面向应用的计算结构生物学家将接触到最新的方法学进展（并提供建议改进的反馈），并在其中实验者将有机会刺激计算生物学家的思维，无论是那些谁主要感兴趣的应用程序，和那些其主要兴趣是算法的发展。我们建议于2011年3月30日至4月1日在亚拉巴马的Point Clear的Grand Hotel Marriott举行计划的三次年度会议中的第一次会议，为期三天。大约三分之二的平台发言人的插槽将保留膜，脂蛋白和蛋白质和RNA和核糖体的三分之一。两名主讲嘉宾，加州理工学院化学系教授Harry Gray及约翰霍普金斯大学医学院分子生物学及遗传学系教授Rachel绿色，已同意加入该两名私人研究员为首届会议的筹备委员会成员。除主旨发言人外，还有9名平台发言人，包括4名妇女和1名少数民族，已承诺参加2011年的专题讨论会。计划中的三个会议系列中的第二个将于2012年春季在格鲁吉亚州的一个待定地点在格鲁吉亚理工学院外举行。该系列的最后一次会议将于2013年春季在第三个州的一个中立地点举行，地点待定，不一定在东南部。