Reducing Dynamic Hyperinflation through Breathing Retraining

通过呼吸再训练减少动态恶性通货膨胀

基本信息

  • 批准号:
    8839265
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

Abstract Dynamic hyperinflation limits exercise duration in chronic obstructive pulmonary disease (COPD). To limit dynamic hyperinflation during exercise and thus improve exercise duration, we successfully developed a visual-auditory ventilation-feedback system. The system retrains patient's breathing pattern during exercise. The goal of the current proposal is to develop a user-friendly ventilation-feedback technique with a novel auditory feedback system. We reason that the proposed feedback system plus exercise training will be superior to exercise training alone while having the potential for an easier application into clinical practice. Hypotheses: The primary hypothesis is that the exercise duration of patients with moderate-to-severe COPD who successfully complete a 12-week program of breathing retraining plus exercise will be longer than that of patients who complete a 12-week program of treadmill exercise training alone. We also hypothesize that the primary predictor of improved exercise duration will be a reduction in dynamic hyperinflation and to a lesser extent, improvement in peripheral muscle function. Lastly, we hypothesize that dyspnea will be reduced in patients assigned to breathing retraining plus exercise when compared to exercise training alone. Methods: The proposed study is a randomized controlled clinical trial. 246 patients with moderate-to-severe COPD will be enrolled and randomized into breathing retraining plus exercise or exercise training alone. Both groups will receive 12-weeks of treadmill exercise training three times weekly. The breathing retraining plus exercise group will also receive auditory feedback to decrease respiratory rate and prolong exhalation. The goal of breathing retraining is to reduce exercise- induced dynamic hyperinflation. Follow-up testing will be completed at 6, 12, and 24 weeks. Testing will include a pulmonary function test, symptom-limited and constant workrate treadmill tests, six-minute walk, dyspnea measurements, testing of respiratory muscle strength and endurance, and quadriceps muscle endurance testing. Analysis: Measures of central tendency will be used to describe the study sample. A two-sample t-test (¿ = 0.05) will be used to analyze changes from baseline to 12-weeks between the breathing retraining plus exercise group and exercise training alone group. In data analysis, intention-to-treat principles will be used. Since several measures will be taken on each patient, mixed-models analysis will be used to compare changes over time between the two groups. Multiple regression analysis will be employed to determine the predictors of improved exercise performance.
摘要 动态过度充气限制慢性阻塞性肺疾病患者的运动持续时间 (COPD)。为了限制运动期间的动态过度充气,从而改善运动持续时间, 我们成功地开发了一个视听通气反馈系统。系统重新训练 患者在运动时的呼吸模式。目前提案的目标是制定一个 用户友好的通气反馈技术与一种新的听觉反馈系统。我们推理 建议的反馈系统加运动训练将优于运动训练的上级 同时具有更容易应用于临床实践的潜力。假设条件: 主要假设是中重度COPD患者的运动持续时间 成功完成为期12周的呼吸再训练加锻炼计划的人将被 比完成12周跑步机运动训练的患者更长 一个人我们还假设,改善运动持续时间的主要预测因素是 减少动态过度充气,并在较小程度上改善外周肌肉 功能最后,我们假设,呼吸困难将减少患者分配到呼吸 再培训加运动与单纯运动训练相比。方法:建议 本研究为随机对照临床试验。246例中重度COPD患者将 入组并随机分为呼吸再训练加运动或单独运动训练。 两组都将接受为期12周的跑步机运动训练,每周三次。的 呼吸再训练加运动组也将获得听觉反馈,以减少 呼吸频率和延长呼气。呼吸训练的目的是减少运动量- 引起动态过度膨胀。将在第6、12和24周完成随访试验。 测试将包括肺功能测试,极限负荷和恒定工作率跑步机 测试,六分钟步行,呼吸困难测量,呼吸肌强度测试, 耐力和股四头肌耐力测试。分析:中央 趋势将用于描述研究样本。将使用双样本t检验(<$= 0.05) 分析从基线到12周呼吸再训练加运动之间的变化 运动训练组和单纯运动训练组。在数据分析中,意向治疗原则将被 采用由于将对每个患者采取几种措施,因此将进行混合模型分析。 用于比较两组之间随时间的变化。多元回归分析将 用于确定改善运动表现的预测因素。

项目成果

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Eileen G Collins其他文献

Eileen G Collins的其他文献

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{{ truncateString('Eileen G Collins', 18)}}的其他基金

Sustainability of Rehabilitation Gains in COPD
慢性阻塞性肺病康复成果的可持续性
  • 批准号:
    8782898
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Sustainability of Rehabilitation Gains in COPD
慢性阻塞性肺病康复成果的可持续性
  • 批准号:
    9136713
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Sustainability of Rehabilitation Gains in COPD
慢性阻塞性肺病康复成果的可持续性
  • 批准号:
    9038788
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
Structured Exercise in Obese Diabetic Patients with Chronic Kidney Disease: A Ran
肥胖糖尿病慢性肾病患者的结构化运动:A Ran
  • 批准号:
    8857415
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Structured Exercise in Obese Diabetic Patients with Chronic Kidney Disease: A Ran
肥胖糖尿病慢性肾病患者的结构化运动:A Ran
  • 批准号:
    7871167
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Structured Exercise in Obese Diabetic Patients with Chronic Kidney Disease: A Ran
肥胖糖尿病慢性肾病患者的结构化运动:A Ran
  • 批准号:
    8466781
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Structured Exercise in Obese Diabetic Patients with Chronic Kidney Disease: A Ran
肥胖糖尿病慢性肾病患者的结构化运动:A Ran
  • 批准号:
    8856555
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Reducing Dynamic Hyperinflation through Breathing Retraining
通过呼吸再训练减少动态恶性通货膨胀
  • 批准号:
    7888245
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Reducing Dynamic Hyperinflation through Breathing Retraining
通过呼吸再训练减少动态恶性通货膨胀
  • 批准号:
    7748064
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Reducing Dynamic Hyperinflation through Breathing Retraining
通过呼吸再训练减少动态恶性通货膨胀
  • 批准号:
    8668985
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:

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