Intron retention regulation in granulopoiesis and leukaemia

粒细胞生成和白血病中的内含子保留调节

• 批准号: nhmrc : 1061906
• 负责人: Dr William Ritchie
• 金额: $ 38.3万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/intron-retention-regulation-granulopoiesis-leukaemia/454941
• 关键词: Intron; retention; regulation; granulopoiesis; leukaemia

Our project will shed light on the development of white blood cells, and what goes wrong when they become cancerous. In particular we have uncovered an unexpected control mechanism of gene expression in these cells. This mechanism governs the specific removal of molecules involved in transmitting information in cells (mRNAs). By extending our research to a cancer of white blood cells called chronic myeloid leukaemia, we hope to provide new insights into its causes and discover targets for innovative drugs.

我们的项目将揭示白色血细胞的发展，以及当它们癌变时会出现什么问题。特别是，我们发现了这些细胞中基因表达的意想不到的控制机制。这种机制控制着参与细胞中信息传递的分子（mRNA）的特异性去除。通过将我们的研究扩展到一种称为慢性髓性白血病的白色血细胞癌症，我们希望为其病因提供新的见解，并发现创新药物的靶点。