Exploring roles for microRNAs in cancer using bioinformatics and gene expression tools.

使用生物信息学和基因表达工具探索 microRNA 在癌症中的作用。

• 批准号: nhmrc : 571156
• 负责人: Dr William Ritchie
• 金额: $ 19.51万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-roles-micrornas-expression-tools/116162
• 关键词: Exploring; roles; microRNAs; cancer; using

microRNAs are newly discovered chemicals that were the subject of the 2006 Nobel Prize in Medicine. These chemicals decrease the amount of specific molecular ‘targets’ in cells, and play an important role in cancer. Currently we do not understand how these chemicals choose their targets, and we propose to use a computer-based approach to discover how they affect genes in cancer. This will improve our understanding of cancer and thereby lead to the discovery of novel anti-cancer therapies.

MicroRNAs是一种新发现的化学物质，是2006年诺贝尔医学奖的主题。这些化学物质减少了细胞中特定分子“靶点”的数量，并在癌症中发挥了重要作用。目前，我们不了解这些化学物质是如何选择靶点的，我们建议使用一种基于计算机的方法来发现它们如何影响癌症中的基因。这将提高我们对癌症的理解，从而导致新的抗癌疗法的发现。