Core A: Administrative Core

核心A：行政-摘要 加州大学圣地亚哥分校阿尔茨海默病研究中心（ADRC）为以下方面的研究进展做出了巨大贡献： 过去30年在更新期间，中心将保持强有力的行政管理， 设定目标和方向，为研究者维持一个支持性的环境，管理核心、项目和 人员，并与大学管理，NIH和其他中心的研究人员互动。自抗扰控制 将强调3个研究主题：1）AD早期阶段的详细表型，包括轻度认知障碍 损害（MCI）和临床前AD; 2）对非AD痴呆的研究; 3） AD和相关疾病中的神经变性，强调转化研究。 行政核心的具体目标包括： 1)为ADRC提供全面的科学领导，推进其使命，确保资源 available. 2)监督和支持ADRC的核心和项目。3)建立协同作用和协作 加州大学圣地亚哥分校和退伍军人医疗中心的临床医生和研究人员。4)继续并加强合作 与圣地亚哥其他优秀生物医学研究机构的研究人员一起工作。5)伙伴 社区组织和保健网络，以促进教育和加强招聘。这 包括阿尔茨海默病协会和其他患者组织，以及圣地亚哥的医生 健康维护组织6)每年征集试点研究项目，安排评审并提交国家创新局。7)提供 为中心提供良好的财务管理。8)每年与我们的外部顾问进行沟通和会面 纸板. 9)与其他ADC、NACC和ADCS互动，以支持多ADC项目和倡议， 包括临床试验。10)与NIA和NACC保持联络，并参加半年度的国家AD中心会议。 11)确保ADRC员工了解并遵守法规。12)保持详细的 并更新网站，突出ADRC的研究，为公众和研究人员。

CORE A: ADMINISTRATIVE - ABSTRACT The UCSD Alzheimer's Disease Research Center (ADRC) has contributed greatly to research progress in the past 30 years. Strong administrative management of the Center will be maintained during the renewal to set goals and direction, maintain a supportive environment for investigators, manage Cores, projects and personnel, and interact with University Administration, NIH, and researchers at other Centers. The ADRC will emphasize 3 research themes: 1) detailed phenotyping of early stages of AD, including Mild Cognitive Impairment (MCI) and preclinical AD; 2) research into non-AD dementias; 3) Basic studies of neurodegeneration in AD and related disorders, emphasizing translational research. Specific Aims of the Administrative Core include: 1) Provide overall scientific leadership to the ADRC and advance its mission, ensuring that resources are available. 2) Oversee and support Cores and Projects of the ADRC. 3) Build synergy and collaborations with clinicians and researchers at UCSD and VA Medical Center. 4) Continue and strengthen collaboration with researchers at other outstanding biomedical research institutions in San Diego. 5) Partner with community organizations and health care networks to advance education and enhance recruitment. This includes the Alzheimer Association and other patient organizations, and physicians at large San Diego HMOs. 6) Solicit Pilot research projects each year, arrange for review and submission to NIA. 7) Provide sound fiscal management for the Center. 8) Communicate and meet annually with our External Advisory Board. 9) Interact with other ADCs, NACC and ADCS to support multi-ADC projects and initiatives, including clinical trials. 10) Liaise with NIA and NACC and attend semi-annual national AD Center meetings. 11) Ensure that ADRC staff are knowledgeable about and comply with regulations. 12) Maintain a detailed and updated website to highlight ADRC research, for the public and researchers.