Methods for Measurement Error in Physical Activity & Diet Data

描述(申请人提供)：建议的项目是为了响应PAR-12-197，改善饮食和体力活动评估。我们主要感兴趣的是开发和应用创新的统计方法，以评估或纠正体力活动和饮食摄入量数据中的测量误差。我们的动机是2005年至2009年进行的女性营养与锻炼(NEW)研究中涉及的体力活动测量问题。这项新的研究是一项为期12个月的随机对照试验，采用四臂设计，比较三种改变生活方式的干预措施(饮食减肥、中等强度有氧运动或两者结合)与对照组(不改变生活方式)的效果。这项建议的具体重点包括：(I)开发和应用广义线性模型中的方法，以调整体力活动和饮食摄入量数据中的测量误差，当它们的分位数用作协变量时。(2)开发和应用生存分析方法，以调整体力活动和饮食摄入量数据中的测量误差，当这些数据的分位数用作协变量时。(3)制定和应用调整纵向体力活动和饮食摄入量数据测量误差的方法，以便在没有复制数据的情况下进行调整。建议的模型和方法将应用于新研究和妇女健康倡议(WHI)的体力活动数据。此外，提案中开发的方法将普遍应用于其他体力活动和饮食摄入量数据的研究。

DESCRIPTION (provided by applicant): The proposed project is in response to PAR-12-197, Improving Diet and Physical Activity Assessment. We are primarily interested in developing and applying innovative statistical methods to assess or correct for measurement errors in physical activity and dietary intake data. We are motivated by physical activity measurement issues involved in the Nutrition and Exercise in Women (NEW) study, conducted from 2005 to 2009. The NEW study was a 12-month randomized, controlled trial using a 4-arm design to compare the effect of three lifestyle-change interventions (dietary weight loss, moderate-to-vigorous intensity aerobic exercise, or both interventions combined) versus control (no lifestyle change). Specific foci of this proposal include: (i) To develop and apply methods in the generalized linear model to adjust for measurement error in physical activity and dietary intake data when their quantiles are used as covariates. (ii) To develop and apply methods in survival analysis to adjust for measurement error in physical activity and dietary intake data when their quantiles are used as covariates. (iii) To develop and apply methods to adjust for measurement error in longitudinal physical activity and dietary intake data when replicates are not available. The proposed models and methods will be applied to the physical activity data of the NEW study, and the Women's Health Initiatives (WHI). Furthermore, the methods developed in the proposal will have general applications to other studies of physical activity and dietary intake data.