Methods for Measurement Error in Physical Activity & Diet Data

描述（由申请人提供）：拟建项目应PAR-12-197《改善饮食和身体活动评估》的要求。我们主要对开发和应用创新的统计方法来评估或纠正体育活动和饮食摄入数据中的测量误差感兴趣。我们的动机来自于2005年至2009年进行的妇女营养与运动（NEW）研究中涉及的身体活动测量问题。这项新研究是一项为期12个月的随机对照试验，采用四组设计，比较三种生活方式改变干预（饮食减肥、中等至高强度有氧运动或两种干预相结合）与对照组（不改变生活方式）的效果。本提案的具体重点包括：(i)开发和应用广义线性模型中的方法，以调整身体活动和饮食摄入数据中以其分位数作为协变量时的测量误差。（ii）发展和应用生存分析的方法，以调整以体力活动和饮食摄入数据的分位数作为协变量时的测量误差。（iii）开发和应用方法，在无法获得重复数据的情况下，调整纵向体育活动和饮食摄入数据的测量误差。所提出的模型和方法将应用于NEW研究和妇女健康倡议（WHI）的身体活动数据。此外，提案中开发的方法将普遍应用于其他关于体育活动和饮食摄入数据的研究。

DESCRIPTION (provided by applicant): The proposed project is in response to PAR-12-197, Improving Diet and Physical Activity Assessment. We are primarily interested in developing and applying innovative statistical methods to assess or correct for measurement errors in physical activity and dietary intake data. We are motivated by physical activity measurement issues involved in the Nutrition and Exercise in Women (NEW) study, conducted from 2005 to 2009. The NEW study was a 12-month randomized, controlled trial using a 4-arm design to compare the effect of three lifestyle-change interventions (dietary weight loss, moderate-to-vigorous intensity aerobic exercise, or both interventions combined) versus control (no lifestyle change). Specific foci of this proposal include: (i) To develop and apply methods in the generalized linear model to adjust for measurement error in physical activity and dietary intake data when their quantiles are used as covariates. (ii) To develop and apply methods in survival analysis to adjust for measurement error in physical activity and dietary intake data when their quantiles are used as covariates. (iii) To develop and apply methods to adjust for measurement error in longitudinal physical activity and dietary intake data when replicates are not available. The proposed models and methods will be applied to the physical activity data of the NEW study, and the Women's Health Initiatives (WHI). Furthermore, the methods developed in the proposal will have general applications to other studies of physical activity and dietary intake data.