Study of rodent HCV-GBV like viruses
啮齿动物HCV-GBV样病毒的研究
基本信息
- 批准号:8638384
- 负责人:
- 金额:$ 22.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAnimal ModelAnimal VirusesAnimalsBiologicalBiological AssayBiological ModelsBiologyChronicCollectionCoronavirusDataDeer MouseDevelopmentDiseaseElementsGB virus BGB virus CGeneric DrugsGenesGeneticGenetic VariationGenomeGenomicsGenotypeGoalsHantavirusHepatitis CHepatitis C virusHepatitis C-Like VirusesHerpesviridaeHigh-Throughput Nucleotide SequencingHistologicHomologous GeneHumanHuman VirusImmuneImmune responseImmunityImmunologicsImmunoprecipitationInfectionIntegration Host FactorsLaboratoriesLeadLuciferasesMammalsMolecularMusNorovirusOrganPathogenesisPeromyscusPhylogenetic AnalysisPopulationPoxviridaePredispositionPrimatesPropertyProteinsRabies virusResearchRodentSIVSerologicalSerumSeveritiesSuspension substanceSuspensionsSystemTherapeutic InterventionTimeTissue SampleTissuesTranslationsTropismViralVirulenceVirusVirus Diseasesgenome sequencinginfluenzavirusinnovationinsightnovelnovel viruspreventpublic health relevancestructural genomicstissue tropismtooltransmission processvirus host interactionvirus identificationvirus pathogenesis
项目摘要
Project Summary/Abstract
Hepatitis C virus (HCV) and human pegivirus (GB virus C) are globally distributed and infect 2-
5% of the human population. The lack of tractable animal models for these viruses, in particular
for HCV, has hampered the study of infection, transmission, virulence, immunity and
pathogenesis. To address this challenge, we searched for their virus homologs in small
mammals, including wild rodents. Results of our ongoing studies identify, for the first time,
several new species of hepaciviruses (HCV-like viruses) and pegiviruses (GBV-like viruses) in
wild rodents. The presence of genes, encoded proteins and translation elements homologous to
those found in human viruses, lead us to hypothesize that these different rodent virus species
resemble HCV or GBV-C in their biological properties. The proposed genetic and biological
characterization of these novel rodent viruses will enable the development of tractable animal
models with which to study virus-host interactions and may culminate in new strategies for
therapeutic intervention. We propose two specific aims: Aim-1: Identify rodent HCV and GBV-C
like viruses (HGLVs) and characterize their complete genomes, natural host and species
tropism; and Aim-2: Investigate HGLV infection, tissue tropism and pathogenesis using
experimental infections of natural host animal species. Pursuit of these aims will lead to
identification of the new rodent HGLV species that are similar to their human homologs in tissue
tropism and pathogenesis. Results of our studies will open up new avenues of research on HCV
and GBV-C like viruses, and will help in identifying virus and host factors that determine
hepacivirus and pegivirus tissue and species tropism, persistence, virulence, immune escape
and pathogenesis.
项目总结/摘要
丙型肝炎病毒(HCV)和人佩吉病毒(GB病毒C)在全球分布,感染2-
5%的人口。特别是缺乏针对这些病毒的易处理的动物模型,
对于HCV,已经阻碍了对感染、传播、毒力、免疫和
发病机制为了应对这一挑战,我们在小规模的
哺乳动物,包括野生啮齿动物。我们正在进行的研究结果首次确定,
几种新的肝炎病毒(HCV样病毒)和佩吉病毒(GBV样病毒),
野生啮齿动物存在的基因,编码的蛋白质和翻译元件同源
这些在人类病毒中发现的病毒,使我们假设这些不同的啮齿动物病毒种类
与HCV或GBV-C的生物学特性相似。拟议的遗传和生物
这些新的啮齿动物病毒的特性将使开发温顺的动物
研究病毒-宿主相互作用的模型,并可能导致新的策略,
治疗干预我们提出了两个具体目标:目标-1:识别啮齿动物HCV和GBV-C
类病毒(HGLV),并描述其完整的基因组,自然宿主和物种
目的-2:研究HGLV感染,组织嗜性和发病机制,
自然宿主动物物种的实验感染。追求这些目标将导致
在组织中与人类同源物相似的新啮齿类HGLV种的鉴定
归经和发病机理。我们的研究结果将为HCV的研究开辟新的途径
和GBV-C样病毒,并将有助于确定病毒和宿主因素,
肝炎病毒和细小病毒组织和种属嗜性、持久性、毒力、免疫逃逸
和发病机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amit Kapoor其他文献
Amit Kapoor的其他文献
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{{ truncateString('Amit Kapoor', 18)}}的其他基金
A sequence-independent approach for attenuating hepaciviruses
一种与序列无关的减毒肝炎病毒方法
- 批准号:
10598793 - 财政年份:2022
- 资助金额:
$ 22.36万 - 项目类别:
Immune correlates of protection against hepacivirus persistence.
抵抗肝炎病毒持久性的免疫相关性。
- 批准号:
10594475 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Infection and prevalence of a new segmented flavivirus in the United States
美国新分段黄病毒的感染和流行
- 批准号:
10392327 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Immune correlates of protection against hepacivirus persistence.
抵抗肝炎病毒持久性的免疫相关性。
- 批准号:
10378496 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Host response and liver disease in a hepatitis C-like virus rat model
丙型肝炎样病毒大鼠模型中的宿主反应和肝病
- 批准号:
10328917 - 财政年份:2018
- 资助金额:
$ 22.36万 - 项目类别:
Host response and liver disease in a hepatitis C-like virus rat model
丙型肝炎样病毒大鼠模型中的宿主反应和肝病
- 批准号:
10084805 - 财政年份:2018
- 资助金额:
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Novel viruses and viral dynamics in multiple transfusion recipients
多次输血受者中的新型病毒和病毒动态
- 批准号:
9251876 - 财政年份:2016
- 资助金额:
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Novel viruses and viral dynamics in multiple transfusion recipients
多次输血受者中的新型病毒和病毒动态
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8697351 - 财政年份:2014
- 资助金额:
$ 22.36万 - 项目类别:
Study of a novel picornavirus genus associated with Acute Flaccid Paralysis
与急性弛缓性麻痹相关的新型小核糖核酸病毒属的研究
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7896237 - 财政年份:2011
- 资助金额:
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