Study of rodent HCV-GBV like viruses
啮齿动物HCV-GBV样病毒的研究
基本信息
- 批准号:8638384
- 负责人:
- 金额:$ 22.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAnimal ModelAnimal VirusesAnimalsBiologicalBiological AssayBiological ModelsBiologyChronicCollectionCoronavirusDataDeer MouseDevelopmentDiseaseElementsGB virus BGB virus CGeneric DrugsGenesGeneticGenetic VariationGenomeGenomicsGenotypeGoalsHantavirusHepatitis CHepatitis C virusHepatitis C-Like VirusesHerpesviridaeHigh-Throughput Nucleotide SequencingHistologicHomologous GeneHumanHuman VirusImmuneImmune responseImmunityImmunologicsImmunoprecipitationInfectionIntegration Host FactorsLaboratoriesLeadLuciferasesMammalsMolecularMusNorovirusOrganPathogenesisPeromyscusPhylogenetic AnalysisPopulationPoxviridaePredispositionPrimatesPropertyProteinsRabies virusResearchRodentSIVSerologicalSerumSeveritiesSuspension substanceSuspensionsSystemTherapeutic InterventionTimeTissue SampleTissuesTranslationsTropismViralVirulenceVirusVirus Diseasesgenome sequencinginfluenzavirusinnovationinsightnovelnovel viruspreventpublic health relevancestructural genomicstissue tropismtooltransmission processvirus host interactionvirus identificationvirus pathogenesis
项目摘要
Project Summary/Abstract
Hepatitis C virus (HCV) and human pegivirus (GB virus C) are globally distributed and infect 2-
5% of the human population. The lack of tractable animal models for these viruses, in particular
for HCV, has hampered the study of infection, transmission, virulence, immunity and
pathogenesis. To address this challenge, we searched for their virus homologs in small
mammals, including wild rodents. Results of our ongoing studies identify, for the first time,
several new species of hepaciviruses (HCV-like viruses) and pegiviruses (GBV-like viruses) in
wild rodents. The presence of genes, encoded proteins and translation elements homologous to
those found in human viruses, lead us to hypothesize that these different rodent virus species
resemble HCV or GBV-C in their biological properties. The proposed genetic and biological
characterization of these novel rodent viruses will enable the development of tractable animal
models with which to study virus-host interactions and may culminate in new strategies for
therapeutic intervention. We propose two specific aims: Aim-1: Identify rodent HCV and GBV-C
like viruses (HGLVs) and characterize their complete genomes, natural host and species
tropism; and Aim-2: Investigate HGLV infection, tissue tropism and pathogenesis using
experimental infections of natural host animal species. Pursuit of these aims will lead to
identification of the new rodent HGLV species that are similar to their human homologs in tissue
tropism and pathogenesis. Results of our studies will open up new avenues of research on HCV
and GBV-C like viruses, and will help in identifying virus and host factors that determine
hepacivirus and pegivirus tissue and species tropism, persistence, virulence, immune escape
and pathogenesis.
项目概要/摘要
丙型肝炎病毒(HCV)和人类pegivirus(GB病毒C)在全球分布并感染2-
占人口的5%。缺乏针对这些病毒的易处理的动物模型,特别是
HCV 的感染、传播、毒力、免疫和
发病。为了应对这一挑战,我们在小样本中搜索了它们的病毒同源物
哺乳动物,包括野生啮齿动物。我们正在进行的研究结果首次确定,
几种新的肝炎病毒(HCV 样病毒)和 Pegiviruses(GBV 样病毒)
野生啮齿动物。存在与以下同源的基因、编码蛋白质和翻译元件
这些在人类病毒中发现的病毒使我们假设这些不同的啮齿动物病毒种类
其生物学特性类似于 HCV 或 GBV-C。拟议的遗传和生物学
这些新型啮齿动物病毒的表征将使驯服动物的开发成为可能
研究病毒与宿主相互作用的模型,并可能最终产生新的策略
治疗干预。我们提出两个具体目标: Aim-1:识别啮齿动物 HCV 和 GBV-C
像病毒 (HGLV) 一样,并表征其完整基因组、自然宿主和物种
向性;目标 2:利用 HGLV 感染、组织向性和发病机制进行研究
自然宿主动物物种的实验感染。追求这些目标将导致
鉴定新的啮齿动物 HGLV 物种,其组织与其人类同源物相似
向性和发病机制。我们的研究结果将为 HCV 研究开辟新途径
和 GBV-C 等病毒,将有助于识别决定病毒和宿主的因素
肝炎病毒和佩吉病毒组织和物种趋向性、持久性、毒力、免疫逃逸
及发病机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amit Kapoor其他文献
Amit Kapoor的其他文献
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{{ truncateString('Amit Kapoor', 18)}}的其他基金
A sequence-independent approach for attenuating hepaciviruses
一种与序列无关的减毒肝炎病毒方法
- 批准号:
10598793 - 财政年份:2022
- 资助金额:
$ 22.36万 - 项目类别:
Immune correlates of protection against hepacivirus persistence.
抵抗肝炎病毒持久性的免疫相关性。
- 批准号:
10594475 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Infection and prevalence of a new segmented flavivirus in the United States
美国新分段黄病毒的感染和流行
- 批准号:
10392327 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Immune correlates of protection against hepacivirus persistence.
抵抗肝炎病毒持久性的免疫相关性。
- 批准号:
10378496 - 财政年份:2021
- 资助金额:
$ 22.36万 - 项目类别:
Host response and liver disease in a hepatitis C-like virus rat model
丙型肝炎样病毒大鼠模型中的宿主反应和肝病
- 批准号:
10328917 - 财政年份:2018
- 资助金额:
$ 22.36万 - 项目类别:
Host response and liver disease in a hepatitis C-like virus rat model
丙型肝炎样病毒大鼠模型中的宿主反应和肝病
- 批准号:
10084805 - 财政年份:2018
- 资助金额:
$ 22.36万 - 项目类别:
Novel viruses and viral dynamics in multiple transfusion recipients
多次输血受者中的新型病毒和病毒动态
- 批准号:
9251876 - 财政年份:2016
- 资助金额:
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Novel viruses and viral dynamics in multiple transfusion recipients
多次输血受者中的新型病毒和病毒动态
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8697351 - 财政年份:2014
- 资助金额:
$ 22.36万 - 项目类别:
Study of a novel picornavirus genus associated with Acute Flaccid Paralysis
与急性弛缓性麻痹相关的新型小核糖核酸病毒属的研究
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- 资助金额:
$ 22.36万 - 项目类别:
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与急性弛缓性麻痹相关的新型小核糖核酸病毒属的研究
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7896237 - 财政年份:2011
- 资助金额:
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