Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology

申请人的学术生涯证明了对以患者为导向的研究的长期承诺， 在年龄相关心血管疾病的病理生理学研究方面具有广泛的专业知识， 不成比例地折磨老年人，包括心脏收缩功能保留的心力衰竭和 在指导住院医师、心脏病学研究员和老年医学初级教员方面有成功的记录， 心脏病学申请人的职业规划是将其研究兴趣扩展到多学科 通过关注射血功能正常的心力衰竭研究年龄相关的心血管疾病 这部分，占美国心力衰竭病例的一半以上， 主要折磨老年人。在此奖项的任期内，申请人将获得进一步的 通过公共卫生梅尔曼学院的正式课程进行遗传学培训， 与哥伦比亚的基础和临床研究者建立现有的合作关系并形成新的合作关系 大学，并为年轻的临床研究人员制定了成功的指导计划， 老年医学和心脏病学，这将促进合作的跨学科研究。后者将 通过创建大纽约老年心脏病联盟（GNYGCC）来实现 旨在改善老年心血管疾病患者的护理， 提供老年心脏病学课程，作为专业医学教育活动的一部分， 随后，通过开展创新的、由制药商发起的、多中心协作的临床研究， 调查建议的指导计划包括三个其他组成部分：1）密集 以病人为导向的研究的个性化培训; 2）哥伦比亚大学的教学计划， 临床试验设计、数据分析、基金撰写和伦理学; 3）由患者团队进行严格审查 面向研究专家。在以患者为导向的研究中授予职业中期研究者奖 将提供急需的保护时间来实现这些职业目标。哥伦比亚提供了一个强大的 支持申请人职业发展的制度环境。部 内科和心脏病科承诺保护申请人50%的时间 for patient-oriented病人oriented导向research研究and mentoring指导.建议的目标是评估：（1）是否针对 贫血是可能导致HFNEF综合征的许多心外因素之一， 与改善心室功能、功能容量和健康状况相关。(2)为潜在 导致或促成运动不能（缺乏能量）的病理生理机制的差异， 心力衰竭受试者按射血分数保留或降低分层，和（3）心室 使用无创压力容积分析和体动记录仪测定力学和功能能力 接受经皮主动脉瓣置换术的老年人。拟议的研究将继续进行 申请人的职业发展，并提供一个机制，使学员能够获得必要的 开展研究生涯和收集数据以支持赠款申请的技能。最终目标是 促进新一代心脏病学和老年医学研究者的发展 可以在老年心血管疾病的竞技场进行临床研究。

The applicant's academic career demonstrates a longterm commitment to patientoriented research, extensive expertise in the study of the pathophysiology of age related cardiovascular disorders that disproportionately afflict older adults including heart failure with preserved systolic function and a successful record in mentoring residents, cardiology fellows and junior faculty in geriatrics and cardiology. The career plan of the applicant is to expand his research interests to multidisciplinary studies of age related cardiovascular conditions by focusing on heart failure with a normal ejection fraction, which accounts for more than half of the cases of heart failure in the United States and that afflicts predominately older adults. During the tenure of this award, the applicant will gain further training in genetics through formal coursework at the Mailman School of Public Health, strengthen existing and form new collaborative relationships with basic and clinical investigators at Columbia University, and institute a successful mentoring program for young clinical investigators from geriatrics and cardiology that will foster collaborative interdisciplinary investigations. The latter will be achieved by the creation of the Greater New York Geriatric Cardiology Consortium (GNYGCC) aimed at improving the care of older adult patients with cardiovascular disease by organizing and delivering a curriculum in geriatric cardiology as part of professional medical education activities and subsequently by performing innovative, investigatorinitiated, multicenter collaborative clinical investigation. The proposed mentoring program consists of three other components: 1) intensive individualized training in patientoriented research; 2) Columbia University didactic programs on clinical trial design, data analysis, grant writing, and ethics; 3) critical review by a team of patient oriented research experts. Awarding a Midcareer Investigator Award in PatientOriented Research will provide critically needed protected time to achieve these career goals. Columbia provides a strong institutional environment for support of the applicant's career development. The Department of Internal Medicine and Division of Cardiology have committed to protect e50% of the applicant's time for patientoriented research and mentoring. The proposed aims are to evaluate: (1) whether targeting anemia, one of many extracardiac factors that could contribute to the syndrome of HFNEF, is associated with improved ventricular function, functional capacity and health status. (2) for potential differences in pathophysiologic mechanisms that cause or contribute to anergia (lack of energy) in heart failure subjects stratified by a preserved or a reduced ejection fraction and (3) ventricular mechanics and functional capacity using use of noninvasive pressure volume analysis and actigraphy in older adults undergoing percutaneous aortic valve replacement. The proposed studies will advance applicant career development and provide a mechanism by which trainees can acquire the necessary skills to launch a research career and collect data to support grant applications. The ultimate goal is to facilitate the development of a new generation of investigators from both cardiology and geriatrics that can pursue clinical research in the arena of aging cardiovascular disease.