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Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology

老年心脏病学以患者为导向的研究职业生涯中期指导奖

基本信息

批准号：
8965595
负责人：
MATHEW S MAURER
金额：
$ 15.7万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8965595
关键词：
Accounting Address Admission activity Adult Affect Affinity Aging American Amyloid Amyloidosis Aortic Valve Stenosis Applications Grants Atherosclerosis Award Cardiac Cardiology Cardiovascular Diseases Cardiovascular system Caring Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Design Data Data Analyses Development Diagnosis Diagnostic Diet Disease EFRAC Elderly Environment Ethics Evaluation Faculty Fostering Functional disorder Future Generations Geriatric Assessment Geriatrics Goals Grant Health Health Care Costs Heart Diseases Heart failure Hospitalization Hospitals Incidence Individual Institution Intervention Interview Investigation Measures Medical Medicine Mentors Mentorship Midcareer Investigator Award in Patient-Oriented Research Myocardial Myocardial Contraction New York Outcome Participant Patients Peer Group Personal Satisfaction Phenotype Physiological Population Prevalence Prognostic Factor Property Public Health Quality of life Randomized Recurrence Research Research Personnel Restrictive Cardiomyopathy Safety Scanning Sensitivity and Specificity Sodium Chloride Sodium-Restricted Diet Stroke Volume Structure Subgroup Symptoms Syndrome Techniques Testing Time Training United States Universities Ventricular Writing age related base cardiovascular health career career development clinical investigation clinical phenotype hedonic imaging modality improved innovation instrument interest kidney vascular structure mortality multidisciplinary next generation novel outcome forecast patient oriented research peer programs public health relevance skills

项目摘要

DESCRIPTION (provided by applicant): My academic career demonstrates a long-term commitment to patient-oriented research, extensive expertise in the study of the pathophysiology of age related cardiovascular disorders that disproportionately afflict older adults including heart failure with preserved ejection fraction and a successful record in mentoring residents, cardiology fellows and junior faculty in geriatrics and cardiology. My career plan is to expand my research interests to multidisciplinary studies of age related cardiovascular conditions by focusing on: (a) heart failure with a normal ejection fraction, which accounts for more than half of the cases of heart failure in the United States and that afflicts predominately older adults, (b) the emerging phenotype of paradoxically low flow aortic stenosis and (c) TTR cardiac amyloidosis that almost exclusively affects older adults. During the tenure of this award, the applicant will strengthen existing and form new collaborative relationships with basic and clinical investigators at Columbia University and continue a successful mentoring program for young clinical investigators from geriatrics, cardiology and other subspecialty fields of medicine that will foster collaborative interdisciplinary investigations. The latter will be achieved by ongoing development of the Greater New York Geriatric Cardiology Consortium (www.gnygcc.org) aimed at improving the care of older adult patients with cardiovascular disease by performing innovative, investigator initiated, multicenter collaborative clinical investigation. The proposed mentoring program consists of four other components: 1) intensive individualized training in patient oriented research; 2) didactic programs on clinical trial design data analysis, grant writing, and ethics; 3) a group/peer mentoring CoMPAdRE Program (Columbia Mentor Peer Aging Research Program) developmental relationships and 4) critical review by a team of patient oriented research experts and a 360° that will seek to encourage mentees to be the "perfect" protégé and assist them in building a network of evaluation of the PI by mentees and faculty participants. Renewal of this Midcareer Investigator Award in Patient Oriented Research will provide critically needed protected time to achieve these career goals and continuing the mentorship of five current K23 awardees at Columbia University and other mentees at outside institutions and in the pipeline. Columbia provides a strong institutional environment for support of the applicant's career development. The Department of Medicine and Division of Cardiology have committed to protect 50% of the applicant's time for patient oriented research and mentoring. The proposed aims are to evaluate: (1) To determine if the DASH-SR diet post-hospitalization for HF can induce a "hedonic shift" and alter salt sensitivity in older adults (2) To evaluate whether TTR cardiac amyloid is the cause of the phenotype of HFpEF due to paradoxically low flow aortic stenosis in older adults undergoing TAVR/SAVR, (3) To deploy an online comprehensive geriatric assessment (CGA) instrument and conduct 500 interviews to advance care and improve QOL in older adults with CV disease, (4) To evaluate the utility of a novel measure, the myocardial contraction fraction (MCF) for predicting HFpEF. The proposed studies will advance applicant career development and provide a mechanism by which trainees can acquire the necessary skills to launch a research career and collect data to support grant applications. The ultimate goal is to facilitate the development of a new generation of investigators from both cardiology and geriatrics that can pursue clinical research in the arena of aging cardiovascular disease.