Midcareer Mentoring Award for Patient Oriented Research in Geriatric Cardiology

老年心脏病学以患者为导向的研究职业生涯中期指导奖

• 批准号: 8965595
• 负责人: MATHEW S MAURER
• 金额: $ 15.7万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8965595
• 关键词: Accounting; Address; Admission activity; Adult; Affect; Affinity; Aging; American; Amyloid; Amyloidosis; Aortic Valve Stenosis; Applications Grants; Atherosclerosis; Award; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Design; Data; Data Analyses; Development; Diagnosis; Diagnostic; Diet; Disease; EFRAC; Elderly; Environment; Ethics; Evaluation; Faculty; Fostering; Functional disorder; Future; Generations; Geriatric Assessment; Geriatrics; Goals; Grant; Health; Health Care Costs; Heart Diseases; Heart failure; Hospitalization; Hospitals; Incidence; Individual; Institution; Intervention; Interview; Investigation; Measures; Medical; Medicine; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Myocardial; Myocardial Contraction; New York; Outcome; Participant; Patients; Peer Group; Personal Satisfaction; Phenotype; Physiological; Population; Prevalence; Prognostic Factor; Property; Public Health; Quality of life; Randomized; Recurrence; Research; Research Personnel; Restrictive Cardiomyopathy; Safety; Scanning; Sensitivity and Specificity; Sodium Chloride; Sodium-Restricted Diet; Stroke Volume; Structure; Subgroup; Symptoms; Syndrome; Techniques; Testing; Time; Training; United States; Universities; Ventricular; Writing; age related; base; cardiovascular health; career; career development; clinical investigation; clinical phenotype; hedonic; imaging modality; improved; innovation; instrument; interest; kidney vascular structure; mortality; multidisciplinary; next generation; novel; outcome forecast; patient oriented research; peer; programs; public health relevance; skills

 DESCRIPTION (provided by applicant): My academic career demonstrates a long-term commitment to patient-oriented research, extensive expertise in the study of the pathophysiology of age related cardiovascular disorders that disproportionately afflict older adults including heart failure with preserved ejection fraction and a successful record in mentoring residents, cardiology fellows and junior faculty in geriatrics and cardiology. My career plan is to expand my research interests to multidisciplinary studies of age related cardiovascular conditions by focusing on: (a) heart failure with a normal ejection fraction, which accounts for more than half of the cases of heart failure in the United States and that afflicts predominately older adults, (b) the emerging phenotype of paradoxically low flow aortic stenosis and (c) TTR cardiac amyloidosis that almost exclusively affects older adults. During the tenure of this award, the applicant will strengthen existing and form new collaborative relationships with basic and clinical investigators at Columbia University and continue a successful mentoring program for young clinical investigators from geriatrics, cardiology and other subspecialty fields of medicine that will foster collaborative interdisciplinary investigations. The latter will be achieved by ongoing development of the Greater New York Geriatric Cardiology Consortium (www.gnygcc.org) aimed at improving the care of older adult patients with cardiovascular disease by performing innovative, investigator initiated, multicenter collaborative clinical investigation. The proposed mentoring program consists of four other components: 1) intensive individualized training in patient oriented research; 2) didactic programs on clinical trial design data analysis, grant writing, and ethics; 3) a group/peer mentoring CoMPAdRE Program (Columbia Mentor Peer Aging Research Program) developmental relationships and 4) critical review by a team of patient oriented research experts and a 360° that will seek to encourage mentees to be the "perfect" protégé and assist them in building a network of evaluation of the PI by mentees and faculty participants. Renewal of this Midcareer Investigator Award in Patient Oriented Research will provide critically needed protected time to achieve these career goals and continuing the mentorship of five current K23 awardees at Columbia University and other mentees at outside institutions and in the pipeline. Columbia provides a strong institutional environment for support of the applicant's career development. The Department of Medicine and Division of Cardiology have committed to protect 50% of the applicant's time for patient oriented research and mentoring. The proposed aims are to evaluate: (1) To determine if the DASH-SR diet post-hospitalization for HF can induce a "hedonic shift" and alter salt sensitivity in older adults (2) To evaluate whether TTR cardiac amyloid is the cause of the phenotype of HFpEF due to paradoxically low flow aortic stenosis in older adults undergoing TAVR/SAVR, (3) To deploy an online comprehensive geriatric assessment (CGA) instrument and conduct 500 interviews to advance care and improve QOL in older adults with CV disease, (4) To evaluate the utility of a novel measure, the myocardial contraction fraction (MCF) for predicting HFpEF. The proposed studies will advance applicant career development and provide a mechanism by which trainees can acquire the necessary skills to launch a research career and collect data to support grant applications. The ultimate goal is to facilitate the development of a new generation of investigators from both cardiology and geriatrics that can pursue clinical research in the arena of aging cardiovascular disease.

 简介(申请人提供)：我的学术生涯表明我长期致力于以患者为导向的研究，在老年心血管疾病的病理生理学研究方面拥有丰富的专业知识，这些疾病尤其困扰老年人，包括射血分数保留的心力衰竭，以及在指导住院医生、心脏病研究员和老年病学和心脏病学初级教员方面的成功记录。我的职业生涯计划是将我的研究兴趣扩展到年龄相关心血管疾病的多学科研究，重点是：(A)射血分数正常的心力衰竭，它占美国心力衰竭病例的一半以上，主要困扰老年人，(B)新出现的反常低流量主动脉狭窄的表型，以及(C)几乎只影响老年人的TTR心脏淀粉样变性。在该奖项的任期内，申请者将加强与哥伦比亚大学基础和临床研究人员的现有关系并形成新的合作关系，并继续为来自老年病学、心脏病学和医学其他子专业领域的年轻临床研究人员提供成功的指导计划，以促进跨学科合作调查。后者将通过大纽约老年心脏病联盟(www.gnygcc.org)的不断发展实现，该联盟旨在通过进行创新的、由研究人员发起的多中心协作临床研究来改善患有心血管疾病的老年患者的护理。拟议的指导计划包括四个其他部分：1)以患者为导向的研究的强化个体化培训；2)关于临床试验设计数据分析、拨款撰写和伦理的指导计划；3)团体/同行指导比较计划(哥伦比亚大学导师同行老龄化研究计划)发展关系和4)由以患者为导向的研究专家团队进行的批判性审查和360°，旨在鼓励受试者成为“完美的”门生，并帮助他们建立一个评估PI的网络 被辅导者和教职员工参加。这项以患者为中心的研究的职业生涯中期奖的续期将为实现这些职业目标提供亟需的保护时间，并继续指导哥伦比亚大学目前的五名K23获奖者以及外部机构和正在筹备中的其他受指导者。哥伦比亚大学为支持申请人的职业发展提供了强有力的制度环境。医学部和心脏科承诺保护申请者50%的时间用于以患者为导向的研究和指导。建议的目的是评估：(1)确定心衰住院后的DASH-SR饮食是否能引起“享乐性转变”并改变患者对盐的敏感性。 (2)评估TTR心脏淀粉样蛋白是否是接受TAVR/SAVR手术的老年人因反常的低血流主动脉狭窄而导致HFpEF表型的原因，(3)部署在线综合老年评估(CGA)仪器，并进行500次访谈，以推进护理，提高患有心血管疾病的老年人的生活质量，(4)评估一种新的测量方法，即心肌收缩分数(MCF)用于预测HFpEF的有效性。拟议的研究将促进申请者的职业发展，并提供一种机制，使受训人员能够获得启动研究生涯所需的技能，并收集数据以支持拨款申请。最终目标是促进来自心脏病学和老年病学的新一代研究人员的发展，他们可以在这个领域进行临床研究。 老年性心血管疾病的风险。