Core B: PSEUDOVIRUS AND VIRUS PRODUCTION CORE

项目摘要--核心B 核心B将为本计划项目的项目1-3提供材料并执行必要的功能。这个 功能包括产生病毒和假病毒试剂，将突变引入相关的 病毒的质粒和基因组克隆，病毒和伪病毒的大规模生产。核心也将 进行病毒学分析，以测试病毒转导和病毒感染的抑制剂 和小鼠细胞系。核心是这一计划的重要组成部分，将被所有人大量使用 项目。

PROJECT SUMMARY - CORE B Core B will provide materials and carry out functions essential for Projects 1-3 of this Program Project. The functions include the generation of virus and pseudovirus reagents, the introduction of mutations into relevant plasmids and genomic clones of viruses, large scale production of virus and pseudovirus. The core will also perform virological assays using to test inhibitors of virus transduction and virus infection of a variety of human and mouse cell lines. The core is an essential component of this program and will be heavily utilized by all projects.