Social Vigilance and Atherosclerotic Risk

社会警惕和动脉粥样硬化风险

• 批准号: 8724237
• 负责人: Daniel J Taylor
• 金额: $ 53万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8724237
• 关键词: Acute; Adaptive Behaviors; Animal Model; Anxiety; Atherosclerosis; Behavior; Behavioral; Behavioral Mechanisms; Blood Pressure; Blood Vessels; Cardiac; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Chronic stress; Communities; Coronary heart disease; Data; Disadvantaged; Discrimination; Disease; Disease Marker; Environment; Event; Exposure to; Frequencies; Goals; Grant; Health; Hostility; Human; Image; Individual; Individual Differences; Intake; Intervention; Investigation; Laboratories; Life; Link; Measurement; Measures; Mediating; Mediator of activation protein; Methods; Modeling; Monitor; Morbidity - disease rate; Nature; Neighborhoods; Participant; Pathway interactions; Patient Self-Report; Pattern; Physiological; Process; Protocols documentation; Psychological Stress; Psychosocial Stress; Publishing; Reaction; Risk; Risk Factors; Sampling; Sensory; Social Environment; Stress; Surveys; Testing; Thick; Time; Ultrasonography; Workplace; cardiovascular disorder risk; cardiovascular risk factor; cohort; contextual factors; coping; disorder risk; experience; follow-up; heart disease risk; improved; interpersonal conflict; intima media; mortality; optimism; physical conditioning; response; self reported behavior; social; social stress; stressor; theories; trait; vigilance

DESCRIPTION (provided by applicant): Social vigilance is one candidate behavior potentially linking a stress as well as a broad array of individual, social, and contextual stress moderators to cardiovascular disease. Social vigilance reflects a sensory intake process akin to Lazarus and Folkman's conceptualization of stress appraisal where an environment or potential threat is continually monitored and reappraised in order to detect any change in status. Although social vigilance may be an adaptive behavior, sustained vigilance or hyper vigilance may have important health consequences. Data from our respective labs demonstrate that social vigilance evokes exaggerated cardiovascular responses acutely and potentiates larger cardiovascular responses to a subsequent stressor, a mediating pathway linking psychological stress to increased physical disease risk. However, there are no published studies examining the association between vigilance and objective markers of cardiovascular disease. Therefore, the current proposal aims to examine social vigilance as moderator of atherosclerotic risk in a representative community sample as well as test hypotheses regarding acute physiological reactions to vigilance in daily life as a mediator of the stress-related change in atherosclerosis. Social vigilance will be assessed with 2 methods. First, a psychometrically validated measure developed by our lab will be used to assess self-reported behavior. Second, ecological momentary assessment (EMA) will be used to assess the frequency of vigilant behavior at 45-min intervals over a 2-day period in participants' daily lives. The EMA protocol will be paired with ambulatory blood pressure assessment such that each vigilance sampling will be paired with a blood pressure measurement. Ambulatory blood pressure is a demonstrated mediator of atherosclerotic progression. Atherosclerosis will be assessed with 2D ultrasound imaging of the carotid arteries. The carotid ultrasound scan and EMA/ambulatory protocol will be performed at study entry and at a 2 year follow-up. We expect that greater social vigilance (higher self-report, more frequent daily experience) will be associated with higher carotid IMT scores at each time point and predict IMT progression over time. We also expect that daily blood pressure reactivity to vigilance will mediate the effects of vigilance on carotid IMT progression. The results of this study will contribute to an understanding of the basic behavioral pathways linking social stress to CHD risk and inform targeted interventions to modify such behavior.

描述（由申请人提供）：社会警惕性是一种候选行为，可能将压力以及一系列个人，社会和情境压力调节者与心血管疾病联系起来。社会警惕反映了类似于拉撒路和民间人对压力评估的概念化的感官摄入过程，在这种情况下，环境或潜在的威胁不断地监控和重新评估，以发现地位的任何变化。尽管社会警惕性可能是一种适应性行为，但持续的警惕或过度警惕可能会带来重要的健康后果。来自我们各自实验室的数据表明，社会警惕性唤起了夸张的心血管反应，并增强了对随后的压力源的更大心血管反应，这是一种将心理压力与增加身体疾病风险联系起来的中介途径。但是，尚无公开的研究来研究警惕性与心血管疾病的客观标志之间的关联。因此，目前的提案旨在研究代表性社区样本中动脉粥样硬化风险的主持人的社会警惕性，以及关于急性生理反应对日常生活中急性生理反应的测试假设，作为动脉粥样硬化中与压力相关的变化的调解人。社会警惕将通过两种方法进行评估。首先，我们实验室开发的经过心理验证的措施将用于评估自我报告的行为。其次，在参与者的日常生活中，将使用生态瞬时评估（EMA）在2天的时间内以45分钟的间隔评估警惕行为的频率。 EMA方案将与门诊血压评估配对，以便将每种警惕性采样与血压测量配对。卧床血压是动脉粥样硬化进展的介体。动脉粥样硬化将通过对颈动脉的2D超声成像进行评估。颈动脉超声扫描和EMA/门诊方案将在研究条目和2年的随访中进行。我们预计，在每个时间点，更高的社会警惕性（更高的自我报告，更频繁的每日体验）将与更高的颈动脉IMT分数相关，并随着时间的推移预测IMT的进展。我们还期望每天对警惕性的血压反应性将介导警惕对颈动脉IMT进展的影响。这项研究的结果将有助于理解将社会压力与CHD风险联系起来的基本行为途径，并告知有针对性的干预措施以修改这种行为。

项目成果

The Strength of Family Ties: Perceptions of Network Relationship Quality and Levels of C-Reactive Proteins in the North Texas Heart Study.

• DOI: 10.1007/s12160-015-9699-y
• 发表时间: 2015-10
• 期刊: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
• 作者: Uchino BN;Ruiz JM;Smith TW;Smyth JM;Taylor DJ;Allison M;Ahn C
• 通讯作者: Ahn C

Ethnic/racial differences in the association between social support and levels of C-reactive proteins in the North Texas Heart Study.

北德克萨斯心脏研究中社会支持与 C 反应蛋白水平之间关系的民族/种族差异。

• DOI: 10.1111/psyp.12499
• 发表时间: 2016
• 期刊: Psychophysiology
• 影响因子: 3.7
• 作者: Uchino,BertN;Ruiz,JohnM;Smith,TimothyW;Smyth,JoshuaM;Taylor,DanielJ;Allison,Matthew;Ahn,Chul
• 通讯作者: Ahn,Chul

Erratum to: The Strength of Family Ties: Perceptions of Network Relationship Quality and Levels of C-Reactive Proteins in the North Texas Heart Study.

勘误：家庭关系的强度：北德克萨斯心脏研究中对网络关系质量和 C 反应蛋白水平的看法。

• DOI: 10.1007/s12160-015-9720-5
• 发表时间: 2015
• 期刊: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
• 作者: Uchino,BertN;Ruiz,JohnM;Smith,TimothyW;Smyth,JoshuaM;Taylor,DanielJ;Allison,Matthew;Ahn,Chul
• 通讯作者: Ahn,Chul

Mean affect and affect variability may interact to predict inflammation.

平均影响和影响变异性可能相互作用以预测炎症。

• DOI: 10.1016/j.bbi.2023.01.008
• 发表时间: 2023
• 期刊: Brain, behavior, and immunity
• 作者: Jones,DustiR;Ruiz,JohnM;Schreier,HannahMC;Allison,MatthewA;Uchino,BurtN;Russell,MichaelA;Taylor,DanielJ;Smith,TimothyW;Smyth,JoshuaM
• 通讯作者: Smyth,JoshuaM

Evaluating the longitudinal risk of social vigilance on atherosclerosis: study protocol for the North Texas Heart Study.

• DOI: 10.1136/bmjopen-2017-017345
• 发表时间: 2017-08-14
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Ruiz JM;Taylor DJ;Uchino BN;Smith TW;Allison M;Ahn C;Johnson JJ;Smyth JM
• 通讯作者: Smyth JM