Core C- IMMUNOLOGY OF TYPE I DIABETES CORE

1型糖尿病核心免疫学为研究自身免疫提供后勤支持 或1型糖尿病或其他内分泌自身免疫性疾病。核心是病理学系 和免疫学。该核心提供：i)协助维持各种近交系小鼠， 包括传统的非肥胖糖尿病(NOD)小鼠和NOD系，其中各种免疫相关 分子已被删除；二)糖尿病致病菌株的维护和检测方面的培训；三)专门知识 对朗格汉斯岛的隔离和检查进行培训；四)提供服务 使用Balb/c和NOD胚胎干细胞的新的糖尿病小鼠品系；以及v)提供分离的 与免疫学研究相关的细胞、细胞系和单抗。在过去的资助中 在一个周期内，向31名调查员提供了服务，这比提供的服务增加了一倍 到前一个供资周期。这部分地反映了对最频繁请求的服务的利用增加， 维护和提供近交系。这一增长还反映了提供CELL的新服务 分离的免疫细胞、抗体和多肽。核心为以下方面提供服务和帮助 在华盛顿大学培养一支多元化的调查团队，致力于研究 1型糖尿病的发病机制和治疗。此核心的服务有助于推动 1型糖尿病免疫生物学的影响研究。

The Immunology of Type 1 Diabetes Core provides logistic support to investigators examining autoimmune or type 1 diabetes or other endocrine autoimmunities. The Core is centered in the Department of Pathology and Immunology. The Core provides: i) assistance in the maintenance of various inbred mouse lines, including conventional non-obese diabetic (NOD) mice and NOD lines in which a variety of immune-relevant molecules has been deleted; ii) training in the maintenance and testing of diabetogenic strains; iii) expertise in, and training for, the isolation and examination of islets of Langerhans; iv) services for the generation of new diabetogenic mouse strains using Balb/c and NOD embryonic stem cells; and v) provision of isolated cells, cell lines, and monoclonal antibodies relevant for immunological research. During the past funding cycle, services were provided to 31 investigators, which represents a doubling of service provided compared to the prior funding cycle. This reflects, in part, increased utilization of the most frequently requested service, maintenance and provision of inbred strains. The increase also reflects the new services for provision of cell lines, isolated immune cells, antibodies and peptides. The Core provides service to and has helped to cultivate a diverse group of investigators at Washington University with a commitment to studying the pathogenesis and treatment of type 1 diabetes. Services from this Core were instrumental in facilitating high impact studies of the immunobiology of type 1 diabetes.