Investigate the role for Dok adapter proteins in thrombosis and haemostasis.

研究 Dok 接头蛋白在血栓形成和止血中的作用。

• 批准号: nhmrc : 545832
• 负责人: Dr Sascha Hughan
• 金额: $ 10.78万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigate-role-dok-thrombosis-haemostasis/115901
• 关键词: Investigate; role; Dok; adapter; proteins

Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this fellowship I will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.

血小板在血凝块形成、预防出血中起关键作用，并且是促成血栓形成导致心脏病发作和中风的主要因素。许多研究已经确定了促进血小板活性的途径，但对其负调控知之甚少。在这个奖学金中，我将研究蛋白质Dok2和Dok1在血小板负调节中的作用，希望这能导致预防心脏病的新疗法的发展。