Investigation of Dok2 and Dok1 adapter proteins, in the negative regulation of integrin aIIbb3 platelet signalling.

研究 Dok2 和 Dok1 接头蛋白对整合素 aIIbb3 血小板信号传导的负调节作用。

• 批准号: nhmrc : 491039
• 负责人: Dr Sascha Hughan
• 金额: $ 29.79万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-dok2-dok1-platelet-signalling/97521
• 关键词: Investigation; Dok2; Dok1; adapter; proteins

Blood platelets play a key role in blood clot formation, prevention of bleeding and are the principal elements contributing to thrombosis leading to heart attack and stroke. Numerous studies have defined pathways promoting platelet activity, however less is known about their negative regulation. In this grant we will examine the role for proteins, Dok2 and Dok1, in the negative regulation of platelets, hoping this leads to development of novel therapeutics for prevention of cardiac disease.

血小板在血凝块形成、预防出血中起关键作用，并且是促成血栓形成导致心脏病发作和中风的主要因素。许多研究已经确定了促进血小板活性的途径，但对其负调控知之甚少。在这项资助中，我们将研究Dok2和Dok1蛋白在血小板负调控中的作用，希望这能导致预防心脏病的新疗法的开发。