Investigatin the causes of failed efferocytosis in COPD-emphysema with a view to identifying novel theraputic targets

研究 COPD 肺气肿胞吞作用失败的原因，以期确定新的治疗靶点

• 批准号: nhmrc : 508134
• 负责人: Prof Sandra Hodge
• 金额: $ 25.38万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigatin-causes-failed-theraputic-targets/115522
• 关键词: Investigatin; causes; failed; efferocytosis; COPD

COPD is a leading cause of death. Smoking is the major cause of COPD and many sufferers are left with permanent damage and need ongoing treatment even after smoking cessation. Current treatments for COPD generally have limited efficacy. The project will identify the reason for the large number of dying cells and defective clearance of these cells that we have identified in the airways in COPD and study novel treatments that we hope will improve the health and well being of those with COPD.

慢性阻塞性肺病是导致死亡的主要原因。吸烟是慢性阻塞性肺病的主要原因，许多患者留下了永久性损伤，即使在戒烟后也需要持续治疗。目前治疗慢性阻塞性肺病的方法通常疗效有限。该项目将确定大量死亡细胞和我们在COPD气道中发现的这些细胞清除缺陷的原因，并研究新的治疗方法，我们希望能改善COPD患者的健康和福祉。