Investigating B cell development, maintenance and high-affinity antibody production by ENU mutagenesis

通过 ENU 诱变研究 B 细胞发育、维持和高亲和力抗体生产

• 批准号: nhmrc : 1035858
• 负责人: Dr Anselm Enders
• 金额: $ 27.23万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-b-cell-enu-mutagenesis/110986
• 关键词: Investigating; cell; development; maintenance; affinity

B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.

B细胞对于防止感染是必不可少的。本申请旨在鉴定对B细胞的发育或功能至关重要的新基因，并将研究新发现的基因中的突变如何导致B细胞的发育和功能缺陷以及B细胞白血病的发病机制。