Adherence to the HCT Medical Regimen: Influence of Cancer Patient-Cargiver Dyads

遵守 HCT 医疗方案：癌症患者-护理者二元的影响

基本信息

批准号：
8717601
负责人：
DONNA M POSLUSZNY
金额：
$ 10.63万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-20 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8717601
关键词：
Address Adherence Affect Allogenic Attention Behavior Behavioral Blood Bone Marrow Transplantation Cancer Patient Caregivers Caring Catheters Characteristics Clinical Clinical Research Complex Data Deltastab Development Diet Disease Doctor of Philosophy Educational workshop Enrollment Ensure Environment Evaluation Family Family Caregiver Fostering Goals Graft Rejection Health Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Hospitals Immunocompromised Host Intervention Investigation Life Malignant Neoplasms Mediating Medical Medicine Mentored Patient-Oriented Research Career Development Award Mentors Methodology Monitor National Cancer Institute Opportunistic Infections Outcome Outcome Study Patient Discharge Patients Perception Persons Pharmaceutical Preparations Population Problem Solving Procedures Psychologist Randomized Randomized Clinical Trials Regimen Reporting Research Risk Risk Factors Role Schedule Subgroup Testing Training Transplantation Treatment outcome Universities University of Pittsburgh Cancer Institute Work arm base career clinical practice coping design evidence base experience graft vs host disease hematopoietic cell transplantation improved international center medical appointment medical complication medical schools meetings novel patient population physical conditioning problem solving therapy professor programs prospective psychoeducational intervention psychological distress psychosocial research study satisfaction skills social success symposium therapy design therapy development

项目摘要

Project Title: Adherence to the HCT Medical Regimen: Influence of Cancer Patient-Caregiver Dyads PI: Donna M. Posluszny, PhD Dr. Donna Posluszny's career goal is to develop an independent research program focused on designing and evaluating novel behavioral and psychosocial interventions to enhance cancer patient-family caregiver dyads' ability to adhere to complex medical regimens and improve patient physical health outcomes. The K23 award will enable Dr. Posluszny, who is an Assistant Professor of Medicine and a clinical psychologist, to take the necessary first steps towards this goal by providing training in medical regimen research in cancer; behavioral and psychosocial intervention development in the field of adherence research in cancer; and methodologies for conducting and analyzing longitudinal and interventional clinical research with patient and family caregiver dyads. Specifically, the five-year training plan includes (1) formal coursework; (2) regular mentoring from mentors and consultants; (3) participation in seminars, workshops, and national conferences; (4) mentored research; and (5) clinical practice. The combination of Dr. Posluszny's clinical training, the expertise of her mentoring team, and the research environment of the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute will facilitate the successful implementation of the proposed training plan and research study. The research plan is devoted to the implementation of an independent project to evaluate patient and family caregiver adherence to the complex, multicomponent post- hematopoietic stem cell transplantation (HCT) during the first 100 days post HCT and the development and piloting of a patient-caregiver dyad-focused psychoeducational intervention, grounded in the principles of Problem-Solving Therapy, to enhance adherence to the post-HCT medical regimen. Specific aims are (1) investigation of how patients and caregivers divide the responsibilities associated with adherence to the multicomponent post-HCT medical regimen post-hospital discharge; (2) determination of rates of, key risk factors for, and patient health outcomes associated with nonadherence to the post-HCT medical regimen; and (3) development and preliminary evaluation of a pilot patient-caregiver dyad-focused psychoeducational intervention designed to decrease nonadherence to the post-HCT medical regimen. This application addresses the National Cancer Institute's continuing commitment to developing initiatives to understand the role of family in the cancer experience and improve patient health outcomes, and is unique in its dyadic focus on adherence. Collectively, the outcomes of this study will foster the identification of both adaptive and nonadaptive dyadic approaches to adherence to the post-HCT medical regimen and provide the groundwork and preliminary data for a psychoeducational intervention to improve adherence for HCT patients and their family caregivers, and thereby improve patient health outcomes.

项目名称：遵守HCT医疗方案：癌症患者护理人员的影响 PI：Donna M. Posluszny，博士 Donna Posluszny博士的职业目标是制定一个专注于设计和评估新型的行为和社会心理干预措施，以增强癌症患者的家庭护理人员二元组能够遵守复杂的医疗方案并改善患者身体健康结果。 K23奖将使医学助理教授和临床教授Posluszny博士启用心理学家，通过提供医疗方案培训来迈出必要的第一步癌症研究；行为和社会心理干预措施在依从性研究领域的发展癌症;以及用于进行和分析纵向和介入临床研究的方法论病人和家庭护理人员二元组。具体而言，五年培训计划包括（1）正式课程；（2）导师和顾问的定期指导；（3）参加研讨会，研讨会和国家会议；（4）指导研究；（5）临床实践。 Posluszny博士的临床结合培训，她的指导团队的专业知识以及匹兹堡大学的研究环境医学院和匹兹堡大学癌症研究所将促进成功实施拟议的培训计划和研究。该研究计划致力于实施独立项目，以评估患者和家庭护理人员遵守对复杂的多组分后的遵守 HCT和发育后的头100天，造血干细胞移植（HCT）和驾驶患者护理人员二重性心理教育干预措施，基于原则解决问题的疗法，以增强对HCT后医疗方案的依从性。具体目的是（1）调查患者和看护人如何划分与遵守的责任多组分后HCT医疗治疗后院后出院；（2）确定关键风险的费率与HCT后医疗方案不遵守有关的因素和患者健康结果；和（3）试验患者护理人员二聚体心理教育的开发和初步评估干预措施旨在降低对HCT后医疗方案的不遵守。此应用程序地址国家癌症研究所致力于制定倡议以了解家庭的作用在癌症的经验并改善患者的健康状况中，并且在二元组的依从性方面是独一无二的。总的来说，这项研究的结果将促进自适应和非适应性二元的鉴定遵守HCT后医疗方案的方法，并提供基础和初步数据进行心理教育干预措施，以提高HCT患者及其家庭护理人员的依从性，并从而改善患者的健康结果。