Adherence to the HCT Medical Regimen: Influence of Cancer Patient-Cargiver Dyads

遵守 HCT 医疗方案：癌症患者-护理者二元的影响

• 批准号: 8717601
• 负责人: DONNA M POSLUSZNY
• 金额: $ 10.63万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-20 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8717601
• 关键词: Address; Adherence; Affect; Allogenic; Attention; Behavior; Behavioral; Blood; Bone Marrow Transplantation; Cancer Patient; Caregivers; Caring; Catheters; Characteristics; Clinical; Clinical Research; Complex; Data; Deltastab; Development; Diet; Disease; Doctor of Philosophy; Educational workshop; Enrollment; Ensure; Environment; Evaluation; Family; Family Caregiver; Fostering; Goals; Graft Rejection; Health; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hospitals; Immunocompromised Host; Intervention; Investigation; Life; Malignant Neoplasms; Mediating; Medical; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Monitor; National Cancer Institute; Opportunistic Infections; Outcome; Outcome Study; Patient Discharge; Patients; Perception; Persons; Pharmaceutical Preparations; Population; Problem Solving; Procedures; Psychologist; Randomized; Randomized Clinical Trials; Regimen; Reporting; Research; Risk; Risk Factors; Role; Schedule; Subgroup; Testing; Training; Transplantation; Treatment outcome; Universities; University of Pittsburgh Cancer Institute; Work; arm; base; career; clinical practice; coping; design; evidence base; experience; graft vs host disease; hematopoietic cell transplantation; improved; international center; medical appointment; medical complication; medical schools; meetings; novel; patient population; physical conditioning; problem solving therapy; professor; programs; prospective; psychoeducational intervention; psychological distress; psychosocial; research study; satisfaction; skills; social; success; symposium; therapy design; therapy development

Project Title: Adherence to the HCT Medical Regimen: Influence of Cancer Patient-Caregiver Dyads PI: Donna M. Posluszny, PhD Dr. Donna Posluszny's career goal is to develop an independent research program focused on designing and evaluating novel behavioral and psychosocial interventions to enhance cancer patient-family caregiver dyads' ability to adhere to complex medical regimens and improve patient physical health outcomes. The K23 award will enable Dr. Posluszny, who is an Assistant Professor of Medicine and a clinical psychologist, to take the necessary first steps towards this goal by providing training in medical regimen research in cancer; behavioral and psychosocial intervention development in the field of adherence research in cancer; and methodologies for conducting and analyzing longitudinal and interventional clinical research with patient and family caregiver dyads. Specifically, the five-year training plan includes (1) formal coursework; (2) regular mentoring from mentors and consultants; (3) participation in seminars, workshops, and national conferences; (4) mentored research; and (5) clinical practice. The combination of Dr. Posluszny's clinical training, the expertise of her mentoring team, and the research environment of the University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute will facilitate the successful implementation of the proposed training plan and research study. The research plan is devoted to the implementation of an independent project to evaluate patient and family caregiver adherence to the complex, multicomponent post- hematopoietic stem cell transplantation (HCT) during the first 100 days post HCT and the development and piloting of a patient-caregiver dyad-focused psychoeducational intervention, grounded in the principles of Problem-Solving Therapy, to enhance adherence to the post-HCT medical regimen. Specific aims are (1) investigation of how patients and caregivers divide the responsibilities associated with adherence to the multicomponent post-HCT medical regimen post-hospital discharge; (2) determination of rates of, key risk factors for, and patient health outcomes associated with nonadherence to the post-HCT medical regimen; and (3) development and preliminary evaluation of a pilot patient-caregiver dyad-focused psychoeducational intervention designed to decrease nonadherence to the post-HCT medical regimen. This application addresses the National Cancer Institute's continuing commitment to developing initiatives to understand the role of family in the cancer experience and improve patient health outcomes, and is unique in its dyadic focus on adherence. Collectively, the outcomes of this study will foster the identification of both adaptive and nonadaptive dyadic approaches to adherence to the post-HCT medical regimen and provide the groundwork and preliminary data for a psychoeducational intervention to improve adherence for HCT patients and their family caregivers, and thereby improve patient health outcomes.

项目名称：遵守 HCT 医疗方案：癌症患者-护理人员二元的影响 PI：Donna M. Posluszny 博士 Donna Posluszny 博士的职业目标是开发一个独立的研究项目，重点关注 设计和评估新的行为和社会心理干预措施，以增强癌症患者家庭的影响 护理人员双人组坚持复杂的医疗方案并改善患者身体健康状况的能力。 K23 奖将使 Posluszny 博士成为一名医学助理教授和临床医生 心理学家，通过提供医疗养生培训，为实现这一目标采取必要的第一步 癌症研究；依从性研究领域的行为和心理社会干预发展 癌症;以及进行和分析纵向和介入临床研究的方法 病人和家庭护理人员的二元关系。具体来说，五年培训计划包括（1）正式课程； (2) 导师和顾问的定期指导； (3) 参加研讨会、讲习班和国家级会议 会议； （4）指导研究； (5)临床实践。结合 Posluszny 博士的临床 培训、指导团队的专业知识以及匹兹堡大学的研究环境 医学院和匹兹堡大学癌症研究所将促进成功实施 拟议的培训计划和研究。该研究计划致力于实施 评估患者和家庭护理人员对复杂、多组成部分的术后护理依从性的独立项目 造血干细胞移植 (HCT) 在 HCT 后的前 100 天内以及发育和 试点以患者-护理人员二元为重点的心理教育干预措施，其基础是 问题解决疗法，以增强对 HCT 后医疗方案的依从性。具体目标是（1） 调查患者和护理人员如何划分与遵守规定相关的责任 出院后的多组分 HCT 后医疗方案； (2) 关键风险率的确定 与不遵守 HCT 后医疗方案相关的因素和患者健康结果；和 (3) 试点患者-护理人员二元心理教育的开发和初步评估 旨在减少不遵守 HCT 后医疗方案的干预措施。该应用程序地址 美国国家癌症研究所持续致力于制定举措以了解家庭的作用 其独特之处在于其对依从性的双重关注。 总的来说，这项研究的结果将促进适应性和非适应性二元关系的识别。 遵守 HCT 后医疗方案的方法并提供基础和初步数据 进行心理教育干预，以提高 HCT 患者及其家庭护理人员的依从性，以及 从而改善患者的健康结果。