Cortical GABA in pediatric sports concussion

皮质 GABA 在儿童运动脑震荡中的作用

• 批准号: 8661414
• 负责人: Jeffrey G Ojemann
• 金额: $ 7.18万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8661414
• 关键词: Address; Adolescent; Adult; Age; Animal Model; Area; Biological Markers; Brain; Brain Concussion; Brain Injuries; Brain Part; Brain imaging; Butyric Acids; Chemicals; Childhood; Clinical; Clinical Trials; Cognition; Cognitive; Collaborations; Control Groups; Craniocerebral Trauma; Detection; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Future; Glasgow Coma Scale; Head; Image; Injury; Location; Long-Term Effects; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Medical Imaging; Memory; Metabolic; Methods; Motor Cortex; Neurotransmitters; Pediatric Hospitals; Pilot Projects; Play; Population; Prognostic Marker; Protocols documentation; Radiology Specialty; Recovery; Recruitment Activity; Relative (related person); Research; Risk; Scanning; Severities; Short-Term Memory; Specificity; Spectrum Analysis; Sports; Sports Medicine; Structure; System; Technology; Time; Trauma; Traumatic Brain Injury; Visual Cortex; Work; base; clinically relevant; cognitive function; frontal lobe; imaging modality; interest; neuroimaging; novel; programs; public health relevance; tool

DESCRIPTION (provided by applicant): Pediatric concussion remains without a reliable scanning tool to image injury or guide therapies. Previous studies with MRI use methods, such as diffusion tensor imaging, functional MRI and functional connectivity MRI, that have not yet been sensitive or specific enough to be used as clinical scans. MR spectroscopy allows measures of the chemical composition in parts of the brain. Recent advances in MR spectroscopy allow for the detection of levels of neurotransmitters, including gamma-amino butyric acid (GABA) which is a widespread inhibitory transmitter. GABA function is critical for cognition and may be abnormal in trauma. Abnormal GABA levels may impair recovery in animal models of injury. Our group combines a dedicated sports concussion program, a work-in-progress collaboration with Siemens Medical Imaging group, and an advanced imaging system (3T magnet with 32 channel head coil) along with a radiology research group with expertise in pediatric neuroimaging. We will address several areas of research interest by developing and studying MR spectroscopy of GABA in a tightly defined pediatric sports concussion population, with appropriate controls. Our first aim will detect GABA levels in a clinically relevant time fram (30 min) by applying research protocols to state-of-the art clinical scanners. The second aim will be to demonstrate the difference in GABA between adolescents with concussion and those without. We will use functional MRI of working memory to target the measurement areas to make sure we are sensitive to brain areas at risk in concussion, based on the common deficits in working memory seen after concussion. In the third aim, the GABA levels will be correlated with post-concussion memory assessments and other MRI brain measures of structure and function. These results will form the basis for future clinical trials showing the utility of GABA spectroscopy in the management of pediatric concussion.

描述（由申请人提供）：儿科脑震荡仍然没有可靠的扫描工具来成像损伤或指导治疗。以前的MRI研究使用的方法，如扩散张量成像，功能性MRI和功能连接性MRI，尚未足够敏感或特异性用于临床扫描。磁共振波谱可以测量大脑部分的化学成分。磁共振波谱学的最新进展允许检测神经递质的水平，包括γ-氨基丁酸（GABA），这是一种广泛的抑制性递质。GABA功能对认知至关重要，并且在创伤中可能异常。异常的GABA水平可能会损害损伤动物模型的恢复。我们的团队结合了一个专门的运动脑震荡项目，与西门子医学成像团队正在进行的合作，以及一个先进的成像系统（3 T磁体和32通道头部线圈），沿着一个具有儿科神经成像专业知识的放射学研究团队。我们将解决几个领域的研究兴趣，通过开发和研究磁共振波谱的GABA在一个严格定义的儿科运动脑震荡人群，适当的控制。我们的第一个目标是通过将研究方案应用于最先进的临床扫描仪，在临床相关的时间弗拉姆内（30分钟）检测GABA水平。第二个目的是证明脑震荡青少年和没有脑震荡青少年之间GABA的差异。我们将使用工作记忆的功能性MRI来定位测量区域，以确保我们对脑震荡风险的大脑区域敏感，这是基于脑震荡后工作记忆的常见缺陷。在第三个目标中，GABA水平将与脑震荡后记忆评估和其他MRI大脑结构和功能测量相关。这些结果将成为未来临床试验的基础，显示GABA光谱在儿科脑震荡管理中的实用性。