Investigating Cytoskeletal Dynamics Across the Lifecycle of the Malaria Parasite

研究疟疾寄生虫整个生命周期的细胞骨架动力学

• 批准号: nhmrc : 637341
• 负责人: Dr Jake Baum
• 金额: $ 25.85万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-cytoskeletal-dynamics-malaria-parasite/77060
• 关键词: Investigating; Cytoskeletal; Dynamics; Across; Lifecycle

During its lifecycle the malaria parasite must cross tissues and invade cells in two very different hosts - humans and mosquitos. Although the molecules that drive this process are known, we know nothing about their dynamics in live parasites. Here, we will use state-of-the art microscopy and genetics to dissect parasite motility, tracking proteins in the parasite cell on their journey from human host through to the mosquito - utilising the first Australian malaria-dedicated insectary.

在其生命周期中，疟疾寄生虫必须穿过组织并侵入两种非常不同的宿主-人类和蚊子的细胞。虽然驱动这一过程的分子是已知的，但我们对它们在活寄生虫中的动力学一无所知。在这里，我们将使用最先进的显微镜和遗传学来解剖寄生虫的运动性，跟踪寄生虫细胞中的蛋白质从人类宿主到蚊子的旅程-利用澳大利亚第一个疟疾专用昆虫。