Investigating Cytoskeletal Dynamics Across the Lifecycle of the Malaria Parasite

在其生命周期中，疟疾寄生虫必须跨越组织，侵入两种截然不同的宿主--人类和蚊子--的细胞。虽然驱动这一过程的分子是已知的，但我们对它们在活体寄生虫中的动力学一无所知。在这里，我们将使用最先进的显微镜和遗传学来剖析寄生虫的运动性，跟踪寄生虫细胞从人类宿主到蚊子的旅程中的蛋白质-利用第一个澳大利亚疟疾专用昆虫。

During its lifecycle the malaria parasite must cross tissues and invade cells in two very different hosts - humans and mosquitos. Although the molecules that drive this process are known, we know nothing about their dynamics in live parasites. Here, we will use state-of-the art microscopy and genetics to dissect parasite motility, tracking proteins in the parasite cell on their journey from human host through to the mosquito - utilising the first Australian malaria-dedicated insectary.