Regulation of actin polymerization during malaria parasite invasion of the human erythrocyte

疟疾寄生虫入侵人红细胞期间肌动蛋白聚合的调节

• 批准号: nhmrc : 516763
• 负责人: Dr Jake Baum
• 金额: $ 18.86万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-actin-polymerization-human-erythrocyte/115683
• 关键词: Regulation; actin; polymerization; during; malaria

Malaria parasites depend on successful invasion of red blood cells for their survival. Invasion is powered by a molecular motor based on two key proteins: actin and myosin. Non-specific drugs that inhibit parasite actin block invasion, demonstrating how important its regulation is to parasite success. This project will study several newly identified malaria actin-regulators, aiming to identify new drug targets that will block malaria actin function, stop motility and as such prevent disease.

疟疾寄生虫依赖于红细胞的成功入侵来生存。入侵是由基于两个关键蛋白质的分子马达驱动的：肌动蛋白和肌球蛋白。抑制寄生虫肌动蛋白的非特异性药物阻断了寄生虫的入侵，证明了其调节对寄生虫成功的重要性。该项目将研究几种新发现的疟疾肌动蛋白调节剂，旨在确定新的药物靶点，这些药物将阻断疟疾肌动蛋白功能，停止运动，从而预防疾病。