Modifiers of FMR1-associated Disorders: Application of High Throughput Technologi
FMR1 相关疾病的修饰剂:高通量技术的应用
基本信息
- 批准号:8793381
- 负责人:
- 金额:$ 180.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-22 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAreaBioinformaticsBiological AssayBiological MarkersCandidate Disease GeneCardiovascular DiseasesCerebellar GaitClinical assessmentsCommunitiesDiseaseDrosophila genusDysautonomiasEnsureEnvironmentEpilepsyEstrogensExecutive DysfunctionExposure toF7 geneFMR1FMR1 repeatFMRPFXTASFacultyFamilyFosteringFractureFragile X SyndromeFunctional disorderGene-ModifiedGenesGeneticGenetic EpistasisGenomeGenomicsGoalsHealthHuman GeneticsHypogonadismImpaired cognitionInfertilityInstitutionIntention TremorKnowledgeLeadMenstruationMessenger RNAModelingMutationNeurobiologyNeurodegenerative DisordersNeuropathyOsteoporosisOvarianParkinsonian DisordersPathway interactionsPenetrancePhenotypePopulation GeneticsPremature Ovarian FailurePrevalenceRecording of previous eventsResearchResearch PersonnelResearch Project GrantsResource SharingSampling StudiesScientistSeriesSeveritiesStudentsSystemTailTechnologyTrainingTranslatingTremor/Ataxia SyndromeTurner&aposs SyndromeUniversitiesVariantWomanWorkagedbaseboyscase controlclinically significantexperiencegenetic variantgenome sequencinghigh throughput technologyinnovationinsightmalemedical schoolsmennext generationnovelnovel strategiesoutcome forecast
项目摘要
DESCRIPTION (provided by applicant): The goals of our Center, "Modifiers of FMR1-associated disorders: application of high throughput technologies", are targeted to the RFA research area to Advance the understanding of the pathophysiology of FMR1 Related Conditions. The completion of the proposed aims from the three research projects will lead to the identification of the genetic basis of variable expressivity or incomplete penetrance of FMR1- associated conditions. Project A will focus on the variable expression of epilepsy among boys with Fragile X syndrome (FXS), a co-morbid condition that occurs among 15% of affected boys and we speculate that variation elsewhere in the genome is responsible. Likewise, Project B will focus on the incomplete penetrance of Fragile X tremor/ataxia syndrome (FXTAS) in men, a neurodegenerative disorder among those with the permutation (PM), with a lifetime prevalence of 30% among males. Project C focuses Fragile X association primary ovarian insufficiency (FXPOI), which manifests in 20% of PM carriers as premature ovarian failure (POF), or cessation of menses prior to age 40. POF leads to infertility and estrogen-deficiency related disorders usually reserved for the aged. Our goal is to identify and understand the extent of the epistemic effects of modifying genes on these three Mendelian disorders. The Center will include three projects and two shared cores, all administered by an Administrative Core. Each proposed research project will take the same novel approach to define a set of candidate genes for further study in mammalian systems. They will: 1) use the Recruitment Core B to ascertain the 100 cases and 100 controls drawn from extreme phenotypic tails of each disorder, 2) conduct whole genome sequencing on each of the 100/100 cases/controls series using the expertise and experience of the Genomics and Analytical Core C, and 3) after validating variants, assess the function of prioritized genes using the established phenotypic assays in the corresponding Drosophila models. The research we propose in our Center is highly innovative, using cutting-edge technologies, to answer fundamental questions related to Fragile X-related disorders. All Center investigators are part of Emory University, an institution with possibly the largest group of independent faculty working on Fragile X-related disorders and with nearly a 30-year history of contributions to the field. Moreover, an added synergy and excitement within this Center is driven by the common theme among all the projects, ensuring a highly interactive and productive research environment.
描述(由申请人提供):我们中心的目标,“FMR 1相关疾病的修饰剂:高通量技术的应用”,是针对RFA研究领域,以促进对FMR 1相关疾病的病理生理学的理解。完成这三个研究项目的拟议目标将导致识别FMR 1相关条件的可变表达性或不完全表达性的遗传基础。项目A将专注于脆性X综合征(FXS)男孩癫痫的可变表达,这是一种共病,发生在15%的受影响男孩中,我们推测基因组中其他地方的变异是负责的。同样,项目B将重点关注男性脆性X震颤/共济失调综合征(FXTAS)的不完全复律,这是一种神经退行性疾病,发生在具有置换(PM)的人群中,男性终生患病率为30%。项目C关注脆性X相关性原发性卵巢功能不全(FXPOI),其在20%的PM携带者中表现为卵巢早衰(POF)或40岁之前月经停止。POF导致不孕症和雌激素缺乏相关的疾病,通常是老年人特有的。我们的目标是确定和理解修饰基因对这三种孟德尔疾病的认知影响的程度。该中心将包括三个项目和两个共享核心,全部由一个行政核心管理。每个拟议的研究项目都将采用相同的新方法来定义一组候选基因,以便在哺乳动物系统中进行进一步研究。他们将:1)使用招募核心B来确定从每种疾病的极端表型尾部抽取的100个病例和100个对照,2)使用基因组学和分析核心C的专业知识和经验对100/100个病例/对照系列中的每一个进行全基因组测序,以及3)在验证变体之后,在相应的果蝇模型中使用已建立的表型测定来评估优先基因的功能。我们在我们中心提出的研究是高度创新的,使用尖端技术,回答与脆性X相关疾病有关的基本问题。所有中心的研究人员都是埃默里大学的一部分,埃默里大学可能是研究脆性X相关疾病的最大的独立教师团体,并且在该领域有近30年的贡献历史。此外,该中心内的协同作用和兴奋是由所有项目之间的共同主题驱动的,确保了高度互动和富有成效的研究环境。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stephen T. Warren其他文献
57. MODELING THE LOSS-OF-FUNCTION MUTATION OF OTUD7A WITHIN THE SCHIZOPHRENIA-ASSOCIATED 15Q13.3 MICRODELETION IN HUMAN NEURONS
- DOI:
10.1016/j.euroneuro.2021.07.146 - 发表时间:
2021-10-01 - 期刊:
- 影响因子:
- 作者:
Alena Kozlova;Siwei Zhang;Alex Kotlar;John McDaid;Marc P. Forrest;Hanwen Zhang;Brendan Jamison;David Cutler;Michael Zwick;Zhiping Pang;Alan R. Sanders;Stephen T. Warren;Pablo V. Gejman;Jennifer G. Mulle;Jubao Duan - 通讯作者:
Jubao Duan
Identification of new mutations in the Emery-Dreifuss muscular dystrophy gene and evidence for genetic heterogeneity of the disease.
鉴定 Emery-Dreifuss 肌营养不良症基因的新突变以及该疾病遗传异质性的证据。
- DOI:
10.1093/hmg/4.10.1859 - 发表时间:
1995 - 期刊:
- 影响因子:3.5
- 作者:
Silvia Blone;K. Small;Veronica M.A. Aksmanovic;Michele D'Urso;Alfredo Ciccodicola;Luciano Merlini;Lucia Morandi;Wolfram Kress;John R.W. Yates;Stephen T. Warren;Daniela Toniolo - 通讯作者:
Daniela Toniolo
Disruption of the microRNA pathway by the targeted loss of eIF2C2 results in aberrant primitive streak formation
- DOI:
10.1016/j.ydbio.2006.04.166 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:
- 作者:
Reid S. Alisch;Tamara Caspary;Stephen T. Warren - 通讯作者:
Stephen T. Warren
The molecular basis of fragile X syndrome.
脆性 X 综合征的分子基础。
- DOI:
- 发表时间:
1996 - 期刊:
- 影响因子:0
- 作者:
Derek E. Eberhart;Stephen T. Warren - 通讯作者:
Stephen T. Warren
Fragile dopamine
脆弱的多巴胺
- DOI:
10.1038/455607a - 发表时间:
2008-10-01 - 期刊:
- 影响因子:48.500
- 作者:
David Weinshenker;Stephen T. Warren - 通讯作者:
Stephen T. Warren
Stephen T. Warren的其他文献
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{{ truncateString('Stephen T. Warren', 18)}}的其他基金
Polyglutamine Expansion Length Dependent Pathology
聚谷氨酰胺扩张长度依赖性病理学
- 批准号:
9769891 - 财政年份:2015
- 资助金额:
$ 180.69万 - 项目类别:
Modifiers of FMR1-associated Disorders: Application of High Throughput Technologi
FMR1 相关疾病的修饰剂:高通量技术的应用
- 批准号:
9069622 - 财政年份:2014
- 资助金额:
$ 180.69万 - 项目类别:
2/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
2/5 国际 22q11.2 缺失综合征大脑与行为联盟
- 批准号:
8741990 - 财政年份:2013
- 资助金额:
$ 180.69万 - 项目类别:
2/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
2/5 国际 22q11.2 缺失综合征大脑与行为联盟
- 批准号:
8918747 - 财政年份:2013
- 资助金额:
$ 180.69万 - 项目类别:
2/5 International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome
2/5 国际 22q11.2 缺失综合征大脑与行为联盟
- 批准号:
8581470 - 财政年份:2013
- 资助金额:
$ 180.69万 - 项目类别:
A Chemical Library Screen for Potential Fragile X Therapeutica
潜在脆性 X 治疗的化学库筛选
- 批准号:
7942242 - 财政年份:2009
- 资助金额:
$ 180.69万 - 项目类别:
Epigenetic Marks as Peripheral Biomarkers of Autism
表观遗传标记作为自闭症的外周生物标记
- 批准号:
7844540 - 财政年份:2009
- 资助金额:
$ 180.69万 - 项目类别:
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