Nuclear, Genomic and Molecular Regulation of Type I Interferon Transcription

I 型干扰素转录的核、基因组和分子调控

• 批准号: 8918249
• 负责人: Tae Hoon Kim
• 金额: $ 21.53万
• 依托单位: UNIVERSITY OF TEXAS DALLAS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8918249
• 关键词: Nuclear; Genomic; Molecular; Regulation; Type

DESCRIPTION (provided by applicant): Our long-term goal of this exploratory research proposal is to determine how chromosome conformation and subnuclear position affect the host response to viruses. Significance and role of large-scale nuclear processes of folding and juxtaposition of chromosomal fibers during innate immune response to viruses remain relatively unknown. However, these processes represent unexplored epigenetic targets for modulating the innate immune system for potential therapies. To understand these nuclear processes involved in anti-viral response in human cells, we will characterize the molecular mechanisms that modulate chromosomal conformation and subnuclear location of the type I interferon locus in the genome of diploid fibroblasts and lymphoblasts during viral infection. A better understanding of the regulatory mechanisms involved in the production of type I interferons is fundamental to the development of therapeutic strategies for treating viral infections and inflammatory diseases such as autoimmunity.

描述（由申请人提供）：我们这项探索性研究提案的长期目标是确定染色体构象和亚核位置如何影响宿主对病毒的反应。在对病毒的先天免疫应答期间，染色体纤维的折叠和并列的大规模核过程的意义和作用仍然相对未知。然而，这些过程代表了用于调节先天免疫系统的潜在疗法的未探索的表观遗传靶点。为了了解这些核过程中参与抗病毒反应在人类细胞中，我们将表征的分子机制，调节染色体构象和亚核位置的I型干扰素基因座的二倍体成纤维细胞和成淋巴细胞的基因组中的病毒感染。更好地理解参与I型干扰素产生的调节机制对于治疗病毒感染和炎性疾病如自身免疫的治疗策略的发展是至关重要的。

项目成果

A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities.

• DOI: 10.1093/nar/gku1018
• 发表时间: 2014-11-10
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Banerjee AR;Kim YJ;Kim TH
• 通讯作者: Kim TH

Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions.

• DOI: 10.1371/journal.pone.0136104
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nwigwe IJ;Kim YJ;Wacker DA;Kim TH
• 通讯作者: Kim TH

Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells.

• DOI: 10.1016/j.molcel.2014.02.004
• 发表时间: 2014-04-10
• 期刊: MOLECULAR CELL
• 影响因子: 16
• 作者: Kim, Lark Kyun;Esplugues, Enric;Zorca, Cornelia E.;Parisi, Fabio;Kluger, Yuval;Kim, Tae Hoon;Galjart, Niels J.;Flavell, Richard A.
• 通讯作者: Flavell, Richard A.