Nuclear, Genomic and Molecular Regulation of Type I Interferon Transcription

描述(由申请人提供)：我们这项探索性研究计划的长期目标是确定染色体构象和亚核位置如何影响宿主对病毒的反应。染色体纤维折叠和并列的大规模核过程在对病毒的先天免疫反应中的意义和作用尚不清楚。然而，这些过程代表了未被发现的表观遗传靶点，用于为潜在的治疗调节先天免疫系统。为了了解这些参与人类细胞抗病毒反应的核过程，我们将描述在病毒感染过程中调节二倍体成纤维细胞和淋巴母细胞基因组中I型干扰素基因座染色体构象和亚核位置的分子机制。更好地了解I型干扰素产生的调节机制对于制定治疗病毒感染和自身免疫等炎症性疾病的治疗策略是至关重要的。

DESCRIPTION (provided by applicant): Our long-term goal of this exploratory research proposal is to determine how chromosome conformation and subnuclear position affect the host response to viruses. Significance and role of large-scale nuclear processes of folding and juxtaposition of chromosomal fibers during innate immune response to viruses remain relatively unknown. However, these processes represent unexplored epigenetic targets for modulating the innate immune system for potential therapies. To understand these nuclear processes involved in anti-viral response in human cells, we will characterize the molecular mechanisms that modulate chromosomal conformation and subnuclear location of the type I interferon locus in the genome of diploid fibroblasts and lymphoblasts during viral infection. A better understanding of the regulatory mechanisms involved in the production of type I interferons is fundamental to the development of therapeutic strategies for treating viral infections and inflammatory diseases such as autoimmunity.