FASEB SRC on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lip

FASEB SRC 对脂滴的影响：中性唇储存的代谢后果

• 批准号: 8781623
• 负责人: Tobias C Walther
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8781623
• 关键词: Academy; Address; Adipocytes; Area; Atherosclerosis; Biochemical; Biochemistry; Biogenesis; Biological; Biological Models; Biology; Biophysics; Cardiovascular Diseases; Cells; Cellular biology; Cholesterol Esters; Collaborations; Data; Development; Discipline; Disease; Environment; Explosion; Faculty; Fatty Liver; Feedback; Fostering; Funding; Genetic; Health; Human; Insulin Resistance; Lip structure; Lipids; Lipolysis; Liver; Medicine; Metabolic; Metabolic Diseases; Metabolic syndrome; Metabolism; Myocardium; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Oral; Physiological; Physiology; Postdoctoral Fellow; Prevalence; Process; Proteins; PubMed; Publications; Request for Applications; Research; Research Personnel; Rivers; Scientist; Site; Staging; Students; Therapeutic; Tissues; Triglycerides; Vermont; abstracting; base; career; design; experience; forging; graduate student; innovation; lipid metabolism; meetings; novel; novel therapeutics; oxidation; performing art; posters; public health relevance; rapid growth; symposium; trafficking

DESCRIPTION (provided by applicant): Lipid droplet accumulation is the hallmark of metabolic diseases, including obesity, atherosclerosis and type II diabetes. The increasing prevalence these diseases has prompted an explosion of research on the biology and metabolism of neutral lipids which are stored within lipid droplets (LD) inside cells. The elucidation of fundamental processes such as lipid droplet biogenesis, storage, trafficking, lipolysis, and oxidation is critical in designing new therapeutic strategies for metabolic disorder. This conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids will bring together scientists from numerous disciplines for the purpose of defining, describing, and analyzing critical scientific problems and recent advances in the cell biology, biochemistry, and physiology of lipid droplets. Since the inauguration of this conference in 2007, the lipid droplet field has grown dramatically, which is reflected in the enthusiasm for this conference. Progress in this area of research is also apparent in the now more than 7000 publications in PubMed with a search term "lipid droplets", with more than 1000 hits since beginning of 2012. The rapid growth of the field is attracting particularly young scientists at the start of their career. The conference has a strong tradition providing a forum for young scientists, providing an opportunity to present data and engage in scientific discussion across seniority levels. As the study of lipid droplets is still an emerging field, scientists from a number of backgrounds and scientific disciplines continue to make important contributions. Due to their different background, many researchers have not previously attended the same conferences. Based on our experience, we are confident that the small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior, established investigators. This application requests funding to support the participation of 10 graduate students, postdoctoral fellows, and junior investigators at the conference to be held July 13-18, 2014 at the Vermont Academy Performing Arts Center in Saxtons River, VT. The format will include an opening night Keynote Address, eight sessions of talks with invited speakers, and in each session additional short talks to be selected from submitted abstracts. The session topics include: 1) Composition and Organization of Lipid Droplets; 2) Triglyceride Synthesis and Storage in Lipid Droplets 3) Cell Biology of Lipid Droplets, 4) Lipid Droplets in Model Systems, 5) Cholesterol Ester Synthesis and Storage, 6) Lipid Droplet Turnover, 7) Physiological Consequences of Lipid Droplet Storage, and 8) Genetics of Lipid Droplets and Associated Diseases. Two 2-day poster sessions, as well as the short talks to be selected from abstracts, will allow additional investigators, including graduate students and postdoctoral fellows, to present their research. In addition, two "Meet the experts" sessions will further increase the number of opportunities for junior researchers to connect to established PIs in this field.

描述（由申请人提供）：脂滴积聚是代谢性疾病的标志，包括肥胖、动脉粥样硬化和II型糖尿病。这些疾病的日益流行促使了对储存在细胞内脂滴（LD）中的中性脂质的生物学和代谢的研究爆炸。阐明脂滴生物发生、储存、运输、脂解和氧化等基本过程对于设计代谢紊乱的新治疗策略至关重要。本次会议的脂滴：中性脂质储存的代谢后果将汇集来自众多学科的科学家，以定义，描述和分析关键的科学问题和细胞生物学，生物化学和脂滴生理学的最新进展。自2007年本届大会开幕以来，脂滴领域的发展突飞猛进，这体现在对本届大会的热情上。这一研究领域的进展也很明显，PubMed中现在有7000多篇出版物，检索词为“脂滴”，自2012年初以来有1000多次点击。该领域的快速发展尤其吸引了刚开始职业生涯的年轻科学家。该会议有着悠久的传统，为年轻科学家提供了一个论坛，提供了一个展示数据和进行跨资历科学讨论的机会。由于脂滴研究仍然是一个新兴领域，来自多种背景和科学学科的科学家继续做出重要贡献。由于他们的背景不同， 许多研究人员以前没有参加过同样的会议。根据我们的经验，我们相信，小型会议的形式和隐蔽的会议场地将促进一个亲密和互动的环境中，初级研究人员，包括研究生，博士后研究员和初级教师，将有足够的机会与更高级，建立研究人员互动。 此应用程序要求资助，以支持10名研究生，博士后研究员和初级研究人员参加将于2014年7月13日至18日在佛蒙特州学院表演艺术中心在萨克顿河，佛蒙特州举行的会议。形式将包括开幕之夜的主旨演讲，八次与受邀演讲者的会谈，以及在每次会议上从提交的摘要中选择的额外简短演讲。会议主题包括：1）脂滴的组成和组织; 2）脂滴中的甘油三酯合成和储存; 3）脂滴的细胞生物学; 4）模型系统中的脂滴; 5）胆固醇酯合成和储存; 6）脂滴周转; 7）脂滴储存的生理后果;以及8）脂滴和相关疾病的遗传学。两个为期2天的海报会议，以及从摘要中选择的简短演讲，将允许更多的研究人员，包括研究生和博士后研究员，介绍他们的研究。此外，两个“会见专家”会议将进一步增加初级研究人员与该领域既定PI联系的机会。