Everyday Quality of Life in Blacks and Whites with Osteoarthritis

描述（由申请人提供）：本研究探讨了非裔美国人（AA; Black）和非西班牙裔白人（NHW; White）老年膝关节骨关节炎（OA）患者的疼痛、日常活动和情绪状态与长期生活质量之间的关系。最近的证据表明，在AAs和NHWs之间，这种可能非常衰弱的疾病的经历和影响存在相当大的差异。遗憾的是，在种族/民族（R/E）差异方面的深入研究很少，之前的研究工作是关于种族/民族（R/E）差异在OA症状的基本经历，以及这些症状和相关残疾的情绪影响。本研究通过对OA疼痛、功能残疾和AAs和NHWs情绪健康的纵向研究来解决这一差距。从生物心理社会模型出发，我们将使用功能评估、自我报告以及对活动、症状和情绪状态的实时评估来构建OA如何影响身体和情绪功能的全面视图。具体目的是(1)描述膝关节炎患者疼痛、残疾和情绪健康之间的种族/民族差异；(2)在(a)生物因素中确定这些差异的起源

DESCRIPTION (provided by applicant): This research examines relationships among pain, everyday activities and mood states, and long-term quality of life among African American (AA; Black) and non-Hispanic White (NHW; White) older adults with osteoarthritis (OA) of the knee. Recent evidence suggests considerable divergence in the experience and effects of this potentially very debilitating disorder among AAs and NHWs. Unfortunately, there has been little in-depth research on racial/ethnic (R/E) differences previous work on racial/ethnic (R/E) disparities in basic experience of OA symptoms, and in the emotional impact of those symptoms and related disability. This research addresses that gap in a longitudinal study of OA pain, functional disability and emotional well-being of AAs and NHWs. Working from a biopsychosocial model, we shall use functional assessments, self-reports, and real-time assessments of activities, symptoms and mood states to construct a comprehensive view of how OA affects physical and emotional functioning. Specific aims are (1) to describe racial/ethnic differences in associations among pain, disability, and emotional well-being of persons with OA of the knee; (2) to identify origins of those differences in (a) biological factors such as disease process and general health, (b) social factors such as demographic characteristics, and (ii) psychological factors, including stable personal characteristics and transitory (within-day) affective, cognitive and behavioral responses to knee symptoms; (3) to use experience sampling methods (ESM) and actigraphy to investigate how racial/ethnic differences in global associations among pain, functional limitations and emotional distress are reflected in the daily lives of OA sufferers, and (4) to explore how the interplay of transitory (within-day) symptoms, activities and mood states influences long-term physical and emotional well-being. These aims will be achieved in a 5-year, multi- site project examining cross-sectional and longitudinal associations among demographic and health characteristics, OA-related pain and disability, restriction of everyday activities, and emotional well-being. A sample of 220 AA and 220 NHW adults aged 50+ with physician-diagnosed OA of the knee will complete a comprehensive baseline assessment tapping biological, psychological and social vulnerability to OA pain and its effects; objective functional limitations; pain; activity restriction, and emotiona distress. Immediately post- baseline, participants will complete a 7-day ESM procedure comprising actigraphic assessment of activity levels along with 4 daily telephone contacts to assess current symptoms, activities, and moods. One year later, participants will repeat all measures, including the ESM component, to capture changes in overall physical and emotional well-being as well as patterns of daily activity and moods. Resulting data will offer unprecedented insight into the global factors that differentiate AAs' and NHWs' experience of OA symptoms, and how daily experiences are concatenated to influence longer-term physical and emotional well-being.