Myoelectric Computer Interface to Reduce Muscle Co-Activation after Stroke

肌电计算机接口可减少中风后肌肉的共同激活

• 批准号: 8771863
• 负责人: Marc W. Slutzky
• 金额: $ 22.58万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8771863
• 关键词: Advanced Development; American; Anterior; Biological Assay; Brain; Chronic; Clinic; Computer Interface; Computers; Coupled; Data; Development; Devices; Dose; Equipment; Feedback; Frequencies; Future; Goals; Hand; Impairment; Individual; Isometric Exercise; Joints; Knowledge; Lead; Learning; Maps; Modality; Motor; Movement; Muscle; Neuraxis; Outcome; Outcome Measure; Patients; Quality of life; Research; Staging; Stroke; Survivors; Testing; Therapy Clinical Trials; Torque; Training; Translating; Translations; Triceps Brachii Muscle; Wolves; arm; base; biceps brachii muscle; chronic stroke; conventional therapy; deltoid muscle; disability; dosage; effective therapy; functional improvement; hemiparesis; improved; improved functioning; injured; innovation; insight; kinematics; learned behavior; motor function improvement; motor impairment; motor learning; novel; pectoralis major muscle; public health relevance; stroke therapy; therapy design; trapezius muscle

DESCRIPTION (provided by applicant): Stroke remains the leading cause of chronic disability in the U.S., and more than half of stroke survivors have persistent impairment of arm function despite receiving conventional therapy. In these stroke survivors, a significant cause of impaired arm movement is abnormal co-activation between muscles that normally do not activate together. The long-term goal of this research is to develop a new therapy for stroke using an inexpensive, easily portable device to improve motor function by decoupling abnormally co-activating muscles. This therapy, a myoelectric computer interface (MCI), maps electrical muscle activity onto movements of a cursor in a computer game. This provides direct, detailed feedback about the co-activation of a pair of muscles to the user. Our preliminary results suggest that training with the MCI allows stroke survivors to greatly reduce abnormal co-activation in the targeted arm muscle pair and may also improve function. The objective of this proposal is to determine how to optimize translation of the decoupled muscle activations into functional improvement. We seek to improve motor function in chronic stroke survivors by even more than in our preliminary studies, which assessed isometric MCI training of a single muscle pair. We will test the effects of two different doses of training on motor function. We will also assess the extent to which individual muscles can be decoupled during movement, which is a more functionally relevant condition than isometric activation. The specific aims of the proposal are to 1) determine the extent to which isometric MCI training of multiple muscle pairs improves function, and 2) determine the extent to which movement-based MCI training of multiple muscle pairs improves function. The proposed research is innovative because it applies fundamental insight about abnormal co-activation after stroke to develop a novel treatment modality that will be inexpensive and portable. In addition, it tests the fundamental ability of an injured central nervous system to regain precise control over specific pairs of muscles. The ability to regain precise control of individual muscles is important because it should improve the ability to transfer the learned behavior to functional tasks. This therapy will broadly impact the field sinc it can enable use by a wide range of stroke survivors. This includes those with severe motor impairments, who are those most in need of new therapies. Achieving our objective will be significant because we expect it to lead to development of an effective treatment for impaired movement after stroke and set the stage for initial clinical trials of the therapy. We estimate tht this therapy could benefit at least 1 million stroke survivors in the U.S. alone.

描述（由申请人提供）：中风仍然是美国慢性残疾的主要原因，尽管接受了常规疗法，但超过一半的中风幸存者仍对ARM功能持续损害。 在这些中风幸存者中，这是 手臂运动受损是肌肉之间通常不会一起激活的肌肉之间的异常共激活。 这项研究的长期目标是使用廉价，易于便携的设备开发新的中风疗法，以通过异常共同激活肌肉来改善运动功能。 这种疗法是一种肌电计算机接口（MCI），将电肌活动映射到计算机游戏中光标的运动。 这提供了有关向用户共同激活一对肌肉的直接，详细的反馈。 我们的初步结果表明，对MCI的训练允许中风幸存者大大减少靶向手臂肌肉对异常的共激活，并且也可能提高功能。 该提案的目的是确定如何优化将解耦肌肉激活转化为功能改进的翻译。 我们试图通过比初步研究中更多地改善慢性中风幸存者中的运动功能，该研究评估了单个肌肉对的等距MCI训练。 我们将测试两种不同剂量的训练对运动功能的影响。 我们也会 评估运动过程中可以将单个肌肉解耦的程度，这比等距激活更有功能相关。 该提案的具体目的是：1）确定多个肌肉对的等距MCI训练的程度可改善功能，2）确定多个肌肉对基于运动的MCI训练的程度可改善功能。 拟议的研究具有创新性，因为它采用了有关中风后异常共激活的基本见解，以开发一种新型的治疗方式，这种方法将是便宜且便携的。 此外，它测试了受伤的中枢神经系统重新控制特定肌肉对的基本能力。 重新控制单个肌肉的精确控制的能力很重要，因为它应该提高将学习的行为转移到功能任务的能力。 这种疗法将广泛影响它可以允许多种中风幸存者使用的现场SINC。 这包括那些患有严重运动障碍的人，他们是最需要新疗法的人。 实现我们的目标将是重要的，因为我们希望它会导致中风后有效运动的有效治疗，并为该治疗的初步临床试验奠定了基础。 我们估计，仅在美国，这种疗法至少可以使100万中风幸存者受益。