ASTHMA CONTROL VARIABILITY DURING PREGNANCY

怀孕期间哮喘控制的变异性

• 批准号: 8934517
• 负责人: TIMOTHY PARKER
• 金额: $ 0.56万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2023-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8934517
• 关键词: Accounting; Air; Antigens; Asthma; Autoantigens; Blood; Blood Pressure; Cell Proliferation; Cells; Chronic Disease; Clinic; Clinic Visits; Clinical; Cohort Studies; Commuting; Contractor; Data; Defect; Diet; Educational workshop; Enrollment; Environmental Exposure; Environmental Risk Factor; Exhalation; Exposure to; Fetus; Flow Cytometry; Forced expiratory volume function; Genes; Genetic; Health; Hour; Hypersensitivity; Immune; Immune system; Inflammation; Intake; Knowledge; Literature; Lung Inflammation; Measures; Mediating; Medical Records; Menstrual cycle; National Heart, Lung, and Blood Institute; Nitric Oxide; Outcome; Patients; Pharmaceutical Preparations; Play; Population; Postpartum Period; Pregnancy; Pregnancy Outcome; Process; Questionnaires; Recruitment Activity; Regulation; Regulatory T-Lymphocyte; Reporting; Respiratory physiology; Role; Sampling; Severities; Specimen; Subgroup; Symptoms; United States National Institutes of Health; Urine; Visit; Woman; abstracting; atopy; base; dietary antioxidant; experience; follow-up; improved; inflammatory marker; interest; pathogen; peripheral blood; pregnancy immunology; research study; trafficking

This research study aims to increase understanding of factors that predict poor asthma control during pregnancy as well as add to our knowledge of the basic immunology of pregnancy. Asthma is a common chronic disease and some women experience exacerbation and worsening of their asthma during pregnancy while others improve. Change in asthma severity/control in pregnancy has been noted frequently in the literature (about one-third worsen and one-third improve) but this change is not explored in any depth 1 Patients with asthma may have a defect in regulatory T (Treg) cells, which favors further T H2-cell proliferation 2. Treg cells are integral to the process by which the immune system differentiates foreign antigens (pathogens, etc.) and self antigens and, as such, they also play a key role in mediating pregnancy tolerance 3� Treg can be measured in peripheral blood and the levels vary over the course of pregnancy and post-partum as well as across the menstrual cycle. Foxp3 is the primary gene responsible for Treg regulation. We will investigate predictors of asthma control variability during pregnancy including demographic, biologic, genetic and environmental factors with particular interest in the role of maternal allergy. Pregnancy requires the immune system to tolerate the "not self" fetus and the clinical presentation of asthma including improvement or worsening will contribute to knowledge of the basic immunology of pregnancy. Women who get worse during pregnancy may represent a vulnerable subgroup with respect to environmental exposures, such as poor air quality, which can exacerb asthma and may have an independent effect on poor pregnancy outcomes.

这项研究旨在提高人们对预测怀孕期间哮喘控制不佳的因素的理解，并增加我们对怀孕基本免疫学的了解。哮喘是一种常见的慢性疾病，有些妇女在怀孕期间会加剧和担心哮喘，而另一些女性会改善。在文献中经常注意到怀孕的哮喘严重程度/控制的变化（大约三分之一和三分之一的改善），但在任何深度1患者中均未探索这种变化在调节性T（Treg）细胞中可能存在缺陷（Treg）细胞缺陷，该细胞更有利于Treg the Gulteg and the treg the Indlecress and the Indectians the Inderne the Inderne the Inderal tath parteriation the Indersiatiate anderiatiant andiatiation andiatiation tater（the）。因此，它们在介导妊娠耐受性3中也起着关键作用3. Treg可以在外周血中进行测量，并且在妊娠和产后以及整个月经周期的过程中的水平各不相同。 FOXP3是负责Treg调节的主要基因。我们将研究怀孕期间哮喘控制变异性的预测因子，包括人口统计学，生物学，遗传和环境因素，对母体过敏的作用特别感兴趣。怀孕要求免疫系统忍受“非自我”胎儿，哮喘（包括改善或忧虑）的临床表现将有助于了解妊娠的基本免疫学。怀孕期间恶化的妇女在环境暴露中可能代表一个脆弱的亚组，例如空气质量差，这可能会加剧哮喘，并且可能对不良怀孕结果产生独立的影响。