Southeast Regional Centers of Excellence for Biodefense & Emerging Infectious Di

东南区域生物防御卓越中心

• 批准号: 8437237
• 负责人: PHILIP Frederick SPARLING
• 金额: $ 722.62万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8437237
• 关键词: Alabama; Diagnostic; Emerging Communicable Diseases; Florida; Goals; Infection; Institution; Lead; Mission; North Carolina; Research; Research Personnel; Science; Technology; Therapeutic; Universities; biodefense; biothreat; innovation; member; novel vaccines; programs; therapeutic vaccine; vaccine development

The Region IV Southeast Regional Center of Excellence for Emerging Infections and Biodefense (SERCEB) consists of six member institutions and 15 affiliate institutions across the Southeast. The University of North Carolina at Chapel Hill is the lead institution, with member institutions including the Duke University, Emory University, Vanderbilt University, the University of Alabama at Birmingham and the University of Florida-Gainesville. The goals of SERCEB are to develop new vaccines, therapeutics and diagnostics to better protect the nation against potential bioterrorist and emerging infectious disease threats. This is accomplished through interdisciplinary and collaborative research using cutting-edge science and technologies. SERCEB brings new investigators to the biodefense effort through a combination of educational programs, support of innovative new projects, and the synergistic interactions among its world-class investigators.

第四区东南部新兴感染和生物防御卓越区域中心（SERCEB）由东南部的6个成员机构和15个附属机构组成。查佩尔山的北卡罗来纳州大学是牵头机构，成员机构包括杜克大学、埃默里大学、范德比尔特大学、伯明翰的亚拉巴马大学和佛罗里达盖恩斯维尔大学。SERCEB的目标是开发新的疫苗，治疗和诊断，以更好地保护国家免受潜在的生物恐怖主义和新出现的传染病威胁。这是通过使用尖端科学和技术的跨学科和合作研究来实现的。SERCEB通过教育计划的结合，创新项目的支持以及世界级研究人员之间的协同互动，为生物防御工作带来了新的研究人员。

项目成果

Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3.

• DOI: 10.4049/jimmunol.181.1.17
• 发表时间: 2008-07-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Li, Hanfen;Willingham, Stephen B.;Ting, Jenny P. -Y.;Re, Fabio
• 通讯作者: Re, Fabio

The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1.

单克隆抗体8A1对登革热血清型3株的差异中和机制。

• DOI: 10.1016/j.virol.2013.01.022
• 发表时间: 2013
• 期刊: Virology
• 影响因子: 3.7
• 作者: Zhou,Yang;Austin,SKyle;Fremont,DavedH;Yount,BoydL;Huynh,JeremyP;deSilva,AravindaM;Baric,RalphS;Messer,WilliamB
• 通讯作者: Messer,WilliamB

Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis.

获得 omptin 揭示了鼠疫耶尔森菌中自转运蛋白 YapE 的神秘毒力功能。

• DOI: 10.1111/mmi.12273
• 发表时间: 2013
• 期刊: Molecular microbiology
• 影响因子: 3.6
• 作者: Lawrenz,MatthewB;Pennington,Jarrod;Miller,VirginiaL
• 通讯作者: Miller,VirginiaL

Biosafety Training and Incident-reporting Practices in the United States: A 2008 Survey of Biosafety Professionals.

美国的生物安全培训和事件报告实践：2008 年生物安全专业人员调查。

• DOI: 10.1177/153567600901400305
• 发表时间: 2009
• 期刊: Applied biosafety : journal of the American Biological Safety Association
• 作者: Chamberlain,AllisonT;Burnett,LouannC;King,JenniferP;Whitney,EllenS;Kaufman,SeanG;Berkelman,RuthL
• 通讯作者: Berkelman,RuthL

Piezoelectric inkjet printing of biomimetic inks for reactive surfaces.

用于反应性表面的仿生墨水的压电喷墨打印。

• DOI: 10.1002/smll.200800536
• 发表时间: 2008
• 期刊: Small (Weinheim an der Bergstrasse, Germany)
• 作者: Deravi,LeilaF;Sumerel,JanL;Sewell,SarahL;Wright,DavidW
• 通讯作者: Wright,DavidW