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Diet, Insulin, Dopamine, and Reward

饮食、胰岛素、多巴胺和奖励

基本信息

批准号：
8716599
负责人：
Kenneth D Carr
金额：
$ 20.97万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-11-15 至 2015-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8716599
关键词：
Acetylcholine Acute Address Award Axon Back Behavior Behavioral Binding Brain Budgets Buffers Chronic Cocaine Complement Corpus striatum structure Data Diet Dopamine Eating Endocrine Environment Equilibrium Expenditure Fatty acid glycerol esters Feeding behaviors Financial compensation Food Frequencies Future Goals Hormones Hyperactive behavior Hypothalamic structure IACUC Immunohistochemistry In Vitro Injection of therapeutic agent Insulin Insulin Receptor Interneurons Knockout Mice Laboratories Lateral Left Mediating Microinjections Middle Hypothalamus Mus Nicotinic Receptors Nucleus Accumbens Obesity Pathway interactions Pharmaceutical Preparations Physiologic pulse Presynaptic Terminals Progress Reports Protocols documentation Rattus Records Regimen Regulation Relative (related person)Resources Rewards Rice Rodent Role Satiation Signal Pathway Slice Sucrose Surface Syndrome Testing Time Transgenic Mice Translating Ventral Tegmental Area Wages Whole-Cell Recordings analog base behavior influence cholinergic cost dopamine transporter drug of abuse extracellular feeding food restriction in vivo insulin sensitivity neuronal cell body neurotransmission novel preference psychostimulant putamen receptor sensitivity research study response reward circuitry uptake

项目摘要

As a consequence of Super-storm Sandy and its aftermath, two significant losses set back progress on our multi-PI project, 1 R01 DA033811, Diet, Insulin, Dopamine, and Reward, PIs: Margaret Rice (contact), Kenneth Carr, and Maarten Reith. The first was lost time, and the second was loss of a transgenic mouse line, in which acetylcholine (ACh) was genetically deleted (as described in Patel et al., Nat. Commun., 2012). We are requesting a with-cost extension of 4 months, and a supplement to re-establish this key mouse line. Our laboratories are all fully functional, and we have current IACUC approval for all experiments in this project: Rice protocol 120313-02, approved 4/9/13; Carr protocol 120604-02, approved 2/1/2013; Reith protocol 120807-01, approved 8/30/2012. As also noted in our recently submitted Progress Report, the unobligated balance on this project was 36% of the total budget as of 5/31/13 ($187,879 of the total award, which was $525,864, direct + indirect). It should be noted that 30% carry-over was necessarily expected because Year 1 was truncated by 30% (to 8.5 mo. 9/15/2012 - 5/31/2013). The small additional balance (6%) reflected some decrease in supply expenditures because of down-time in Sandy (although salary support necessarily continued), as well as conservative spending to buffer future budget years in which expenses are expected to increase, and the annual award amount to remain flat or even decrease, as occurred in the current budget year (Year 2). Thus, the current unobligated balance is absolutely essential to achieve the goals of the original application. The present request for a with-cost extension and supplement is a completely separate issue that addresses compensation to restore losses of time and resources from Sandy.

由于超级风暴桑迪及其后果，两次重大损失阻碍了我们的进展，多PI项目，1 R 01 DA 033811，饮食、胰岛素、多巴胺和奖励，PI：Margaret Rice（联系人），肯尼斯卡尔和马丁·里斯。第一个是损失的时间，第二个是转基因小鼠品系的损失，其中乙酰胆碱（ACh）被遗传缺失（如Patel等，国家通信，2012年）。我们我们要求延长4个月的费用，并补充重新建立这个关键的鼠标线。我们的实验室都是功能齐全的，我们有目前的IACUC批准的所有实验在这一点上，项目：Rice方案120313-02，2013年4月9日批准;卡尔方案120604-02，2013年2月1日批准; Reith 方案120807-01，2012年8月30日批准。正如我们最近提交的进度报告所述，截至2013年5月31日，该项目的未支配余额占总预算的36%（总合同的187,879美元， 525，864美元，直接+间接）。应当指出，30%的结转是必然的因为第1年缩短了30%（至8.5个月），2012年9月15日至2013年5月31日）。小额追加余额（6%）由于桑迪的停机时间，供应支出有所减少（尽管薪金支助必要继续），以及保守的支出，以缓冲未来的预算年度，其中费用预计将增加，年度奖励金额将保持不变，甚至减少，就像目前发生的那样，预算年度（第二年）。因此，目前的未支配余额对实现2004 - 2005年的目标绝对必要。原始应用程序。目前关于附带费用的延期和补充的请求是一项完全独立的请求，解决补偿问题，以恢复桑迪造成的时间和资源损失。