Cancer Prevention, Detection and Control

癌症预防、检测和控制

• 批准号: 8601824
• 负责人: AMY P. ABERNETHY
• 金额: $ 5.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8601824
• 关键词: Address; Advanced Malignant Neoplasm; Applied Research; Behavioral; Behavioral Research; Behavioral Sciences; Bioinformatics; Biological; Cancer Control; Cancer Patient; Cancer Survivor; Caring; Clinical Trials; Cognitive; Collaborations; Communication; Communities; Complex; Data; Detection; Development; Diagnosis; Early Diagnosis; Economic Policy; Elderly; Enrollment; Environment; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Epigenetic Process; Family Caregiver; Funding; Genetic; Genetic Research; Goals; Grant; Health; Healthcare; Incidence; Institutes; Institution; Intervention; Investigation; Laboratories; Learning; Malignant Neoplasms; Medicare; Medicine; Minority; Nicotine Dependence; Obesity; Outcome; Outcomes Research; Palliative Care; Paper; Patient Care; Peer Review; Personal Satisfaction; Pharmacologic Substance; Policies; Prevention; Preventive Intervention; Primary Prevention; Psychosocial Assessment and Care; Public Health; Publishing; Quality of life; Research; Schools; Science; Secondary Prevention; Societies; Staging; Symptoms; Tobacco Use Cessation; Translations; United States National Institutes of Health; behavior change; cancer care; cancer prevention; cancer risk; cancer therapy; chemotherapy; cost effectiveness; effective intervention; effective therapy; end of life; epigenetic marker; implementation research; improved; member; novel; nutrition; oncology; palliative; prevent; programs; psychosocial; relating to nervous system; screening; sound; survivorship; symptom management; tumor progression

This program pursues a set of overarching scientific goals: (1) to identify environmental, biological, psychosocial, epigenetic, and genetic factors that influence cancer risk, occurrence, and progression through basic, genetic and epigenetic, and epidemiologic research; (2) to clarify the impact of cancer and cancer treatment through outcomes research; (3) to develop, implement, evaluate, and disseminate educational, behavioral, and psychosocial interventions aimed at preventing cancer, improving eariy detection, enhancing symptom management, improving health and quality of life for cancer survivors, caregivers, and families, and advancing the science to improve palliative and end-of-life care; and (4) to advance cancer prevention, detection, and control within the broader contexts of institution and society through quality, economic, and policy studies. Program activities target five prioritized themes: disparities, tobacco cessation, obesity and nutrition, geriatric oncology, and survivorship (including symptom control and palliative care). Structurally, research within three main program sections - Epidemiology and Genetics Research, Behavioral Sciences Research, Applied Research - address these cross-cutting themes. Leading-edge research is underway in each section; examples are studies of epigenetic markers of cancer risk (Epidemiology and Genetics Research), neural correlates of nicotine addiction (Behavioral Sciences Research), and impact of Medicare policy change on access to chemotherapy (Applied Research). The program is integrally involved in forerunning national and institutional initiatives. Among these directions are: personalized medicine; patientreported outcomes; survivorship care, including palliative and end-of-life care; increasing minority enrollment in clinical trials, incorporation of bioinformatics and complex data functions across the full research spectrum; development of quality assessment approaches; and creation of a learning healthcare environment. This program currently comprises 46 Duke Comprehensive Cancer Institute members across 21 departments, divisions, schools and institutes. Grant funding has increased since our last submission, from $13,177,478 direct funding in 2004 to $21,317,489 in 2008 (11% NCI funding, 40% NIH funding). During the recent fiveyear period, we have published over 1,100 peer-reviewed papers; 152 papers (13%) demonstrate intraprogrammatic collaboration and 162 papers (14%) demonstrate inter-programmatic collaborations.

该计划追求一系列总体科学目标：（1）确定环境，生物， 心理社会、表观遗传和遗传因素通过以下方式影响癌症风险、发生和进展： 基础、遗传和表观遗传以及流行病学研究;（2）阐明癌症和癌症的影响 通过成果研究进行治疗;（3）制定、实施、评估和传播教育， 行为和心理社会干预，旨在预防癌症，提高早期发现， 症状管理，改善癌症幸存者、护理人员和家庭的健康和生活质量，以及 推进科学以改善姑息治疗和临终关怀;以及（4）推进癌症预防， 检测和控制在更广泛的背景下的机构和社会通过质量，经济， 政策研究。方案活动针对五个优先主题：不平等、戒烟、肥胖和 营养、老年肿瘤学和生存率（包括症状控制和姑息治疗）。在结构上， 在三个主要计划部分的研究-流行病学和遗传学研究，行为科学 研究，应用研究-解决这些交叉主题。领先的研究正在进行中， 每个部分;例子是癌症风险的表观遗传标记的研究（流行病学和遗传学 研究），尼古丁成瘾的神经相关性（行为科学研究），以及医疗保险的影响 关于获得化疗的政策变化（应用研究）。该方案整体参与了 在国家和机构倡议之前。这些方向包括：个性化医疗;患者报告 结果;生存护理，包括姑息治疗和临终护理;增加少数民族入学率 在临床试验中，在整个研究范围内纳入生物信息学和复杂的数据功能; 制定质量评估方法;创造学习型医疗保健环境。这 该计划目前包括21个部门的46名杜克综合癌症研究所成员， 部门、学校和研究所。自我们上次提交以来，赠款资金已从13，177，478美元增加 从2004年的直接资助增加到2008年的21，317，489美元（国家癌症研究所资助11%，国家卫生研究所资助40%）。近五年来， 在此期间，我们发表了1,100多篇同行评审论文; 152篇论文（13%）证明了项目内 162篇论文（14%）展示了跨方案合作。