SAFETY OF FUROSEMIDE IN PREMATURE INFANTS AT RISK OF BRONCHOPULMONARY DYSPLASIA

NIH将支气管肺发育不良（BPD）定义为轻度、中度或重度 基于36周龄时调整后的所需呼吸支持。1一个NIH研讨会提出了一个 基于严重程度的定义，根据出生后年龄将BPD分为轻度、中度或重度 或PMA（表2-1）。轻度BPD定义为需要补充氧气（02）约28天，但 在36周PMA或出院时，中度BPD为0 2，持续~ 28天，并在36周时治疗<30% 0 2 重度BPD为0 2，持续~ 2 8d，加~ 30%0 2和/或正压治疗36周 PMA。Escherikranz等人通过将其与NICHD的BPD严重性定义进行比较， 更传统的BPD定义，如在28天和36周PMA时补充氧气。的 NICHD基于严重程度的共识量表更好地识别了肺功能不良风险最高的婴儿。 结果以及神经发育障碍比传统的定义

Bronchopulmonary dysplasia (BPD) is defined by the NIH as mild, moderate, or severe based on the required respiratory support at 36 weeks adjusted age. 1 An NIH workshop proposed a severity-based definition that classifies BPD into mild, moderate or severe based on either postnatal age or PMA (Table 2-1). Mild BPD was defined as a need for supplemental oxygen {02) for~ 28 days but not at 36 weeks PMA or discharge, moderate BPD as 0 2 for~ 28 days plus treatment with <30% 0 2 at 36 weeks PMA, and severe BPD as 0 2 for~ 28 days plus~ 30% 0 2 and/or positive pressure at 36 weeks PMA. Ehrenkranz et af validated the NICHD severity-based definition ofBPD by comparing it to the more traditional definitions ofBPD such as supplemental oxygen at 28 days and at 36 weeks PMA. The NICHD consensus severity based scale better identified infants who are at most risk for poor pulmonary outcomes as well as neurodevelopment impairment than the traditional definitions