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SAFETY OF FUROSEMIDE IN PREMATURE INFANTS AT RISK OF BRONCHOPULMONARY DYSPLASIA

速尿对于有支气管肺发育不良风险的早产儿的安全性

基本信息

批准号：
8940702
负责人：
Brian Smith
金额：
$ 17.51万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-29 至 2015-09-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8940702
关键词：
Acute Adult Age Apgar Score Birth Weight Bronchopulmonary Dysplasia Cessation of life Childhood Clinical Pharmacology Congestive Heart Failure Consensus Disease Distal Diuretics Dose Economics Edema Educational workshop Enrollment Environmental air flow Epidemiologic Studies Ethnic Origin Family Furosemide Gender Gestational Age Glutamine Health Health Care Costs Henle&apos s loop Hospitalization Hour Impairment Infant Intake Kidney Diseases Life Liquid substance Liver Cirrhosis Low Birth Weight Infant Lung Marshal Measures Modeling Morbidity - disease rate National Institute of Child Health and Human Development Necrotizing Enterocolitis Neonatal Nephrotic Syndrome Nosocomial Infections Outcome Oxygen Patent Ductus Arteriosus Patients Premature Infant Pulmonary Edema Pulmonary Hypertension Quality of life Race Research Respiratory Failure Risk Risk Factors Safety Sampling Sepsis Severities Site Sodium Chloride Steroids Stress United States National Institutes of Health Validation Ventilator base cohort cost indexing inhaled nitric oxide intraventricular hemorrhage male neurodevelopment peer postnatal premature pressure respiratory sex social surfactant tool

项目摘要

Bronchopulmonary dysplasia (BPD) is defined by the NIH as mild, moderate, or severe based on the required respiratory support at 36 weeks adjusted age. 1 An NIH workshop proposed a severity-based definition that classifies BPD into mild, moderate or severe based on either postnatal age or PMA (Table 2-1). Mild BPD was defined as a need for supplemental oxygen {02) for~ 28 days but not at 36 weeks PMA or discharge, moderate BPD as 0 2 for~ 28 days plus treatment with <30% 0 2 at 36 weeks PMA, and severe BPD as 0 2 for~ 28 days plus~ 30% 0 2 and/or positive pressure at 36 weeks PMA. Ehrenkranz et af validated the NICHD severity-based definition ofBPD by comparing it to the more traditional definitions ofBPD such as supplemental oxygen at 28 days and at 36 weeks PMA. The NICHD consensus severity based scale better identified infants who are at most risk for poor pulmonary outcomes as well as neurodevelopment impairment than the traditional definitions

NIH将支气管肺发育不良（BPD）定义为轻度、中度或重度基于36周龄时调整后的所需呼吸支持。1一个NIH研讨会提出了一个基于严重程度的定义，根据产后年龄将BPD分为轻度、中度或重度或PMA（表2-1）。轻度BPD定义为需要补充氧气（02）约28天，但在36周PMA或出院时，中度BPD为0 2，持续~ 28天，并在36周时治疗<30% 0 2 重度BPD为0 2，持续~ 2 8d，加~ 30%0 2和/或正压治疗36周 PMA。Escherikranz等人通过将其与NICHD的BPD严重性定义进行比较，更传统的BPD定义，如在28天和36周PMA时补充氧气。的 NICHD基于严重程度的共识量表更好地识别了肺功能不良风险最高的婴儿。结果以及神经发育障碍比传统的定义